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151.
T K Hei Y L Zhao D Roy C Q Piao G Calaf E J Hall 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2001,27(2):411-419
Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process. 相似文献
152.
Ts.P. Dachev B.T. Tomov Yu.N. Matviichuk Pl.G. Dimitrov N.G. Bankov G. Reitz G. Horneck D.-P. Häder M. Lebert M. Schuster 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2012
Space radiation has been monitored successfully using the Radiation Risks Radiometer-Dosimeter (R3D) installed at the ESA EXPOSE-R (R3DR) facility outside of the Russian Zvezda module of the International Space Station (ISS) between March 2009 and January 2011. R3DR is a Liulin type spectrometer–dosimeter with a single Si PIN detector 2 cm2 of area and 0.3 mm thick. The R3DR instrument accumulated about 2 million measurements of the absorbed dose rate and flux of 10 s resolution. The total external and internal shielding before the detector of R3DR device is 0.41 g cm−2. The calculated stopping energy of normally incident particles to the detector is 0.78 MeV for electrons and 15.8 MeV for protons. After the Coronal Mass Ejection (CME) at 09:54 UTC on 3 April 2010, a shock was observed at the ACE spacecraft at 0756 UTC on 5 April, which led to a sudden impulse on Earth at 08:26 UTC. Nevertheless, while the magnetic substorms on 5 and 6 of April were moderate; the second largest in history of GOES fluence of electrons with energy >2 MeV was measured. The R3DR data show a relatively small amount of relativistic electrons on 5 April. The maximum dose rate of 2323 μGy day−1 was reached on 7 April; by 9 April, a dose of 6600 μGy was accumulated. By the end of the period on 7 May 2010 a total dose of 11,587 μGy was absorbed. Our data were compared with AE-8 MIN, CRESS and ESA-SEE1 models using SPENVIS and with similar observations on American, Japanese and Russian satellites. 相似文献
153.
K. C. Hansen T. Bagdonat U. Motschmann C. Alexander M. R. Combi T. E. Cravens T. I. Gombosi Y.-D. Jia I. P. Robertson 《Space Science Reviews》2007,128(1-4):133-166
The plasma environment of comet 67P/Churyumov-Gerasimenko, the Rosetta mission target comet, is explored over a range of heliocentric distances throughout the mission: 3.25 AU (Rosetta instruments on), 2.7 AU (Lander down), 2.0 AU, and 1.3 AU (perihelion). Because of the large range of gas production rates, we have used both a fluid-based magnetohydrodynamic (MHD) model as well as a semi-kinetic hybrid particle model to study the plasma distribution. We describe the variation in plasma environs over the mission as well as the differences between the two modeling approaches under different conditions. In addition, we present results from a field aligned, two-stream transport electron model of the suprathermal electron flux when the comet is near perihelion. 相似文献
154.
Khan M.H. Le-Ngoc T. Bhargava V.K. 《IEEE transactions on aerospace and electronic systems》1985,(4):547-558
Two hybrid schemes of time-frequency resource sharing to increase the rain margin of Ku-and Ka-band satellite systems are proposed. Scheme 1 requires sharing a small pool of bandwidth for adaptive forward error control coding, sharing a small pool of time frame for rate reduction, and sharing a portion of low frequency time-division multiple access (TDMA) back-up frame for downlink transmission to the rain affected stations. Scheme 2 utilizes variable rate modulation and forward error correction, shares a small pool of time frame for rate reduction, and shares a portion of low frequency TDMA back-up frame. Effective usable capacities of the system using these schemes are calculated. Distribution of resources in order to maximize the effective usable capacity is also analyzed. The results obtained are compared with other adaptive schemes. Preliminary analysis shows that the utilized capacity of scheme 1 exceeds 99 percent of the effective usable capacity possible if it never rains for an outage of 0.05 percent and fade margin of 2.5 dB. For scheme 2 similar performance is achievable at a fade margin of 1.5 dB. For higher outage objectives the loss of effective utilized capacity is higher for scheme 2. 相似文献
155.
The primary objective of the Laser Interferometer Space Antenna (LISA) mission is to detect and observe gravitational waves from massive black holes and galactic binaries in the frequency range 10−4 to 10−1 Hz. This low-frequency range is inaccessible to ground-based interferometers because of the unshieldable background of local gravitational noise and because ground-based interferometers are limited in length to a few km. LISA is an ESA cornerstone mission and recently had a system study (Ref. 1) carried out by a consortium led by Astrium, which confirmed the basic configuration for the payload with only minor changes, and provided detailed concepts for the spacecraft and mission design. The study confirmed the need for a drag-free technology demonstration mission to develop the inertial sensors for LISA, before embarking on the build of the flight sensors. With a technology demonstration flight in 2005, it would be possible to carry out LISA as a joint ESA-NASA mission with a launch by 2010 subject to the funding programmatics. The baseline for LISA is three disc-like spacecraft each of which consist of a science module which carries the laser interferometer payload (two in each science module) and a propulsion module containing an ion drive and the hydrazine thrusters of the AOCS. The propulsion module is used for the transfer from earth escape trajectory provided by the Delta II launch to the operational orbit. Once there the propulsion module is jettisoned to reduce disturbances on the payload. Detailed analysis of thermal and gravitational disturbances, a model of the drag-free control and of the interferometer operation confirm that the strain sensitivity of the interferometer will be achieved. 相似文献
156.
Green AR Andrews HR Bennett LG Clifford ET Ing H Jonkmans G Lewis BJ Noulty RA Ough EA 《Acta Astronautica》2005,56(9-12):949-960
In light of the importance of the neutron contribution to the dose equivalent received by space workers in the near-Earth radiation environment, there is an increasing need for a personal dosimeter that is passive in nature and able to respond to this neutron field in real time. Recent Canadian technology has led to the development of a bubble detector, which is sensitive to neutrons, but insensitive to low linear energy transfer (LET) radiation. By changing the composition of the bubble detector fluid (or “superheat”), the detectors can be fabricated to respond to different types of radiation. This paper describes a preliminary ground-based research effort to better characterize the bubble detectors of different compositions at various charged-particle accelerator facilities, which are capable of simulating the space radiation field. 相似文献
157.
A. V. Streltsov J.-J. Berthelier A. A. Chernyshov V. L. Frolov F. Honary M. J. Kosch R. P. McCoy E. V. Mishin M. T. Rietveld 《Space Science Reviews》2018,214(8):118
Active ionospheric experiments using high-power, high-frequency transmitters, “heaters”, to study plasma processes in the ionosphere and magnetosphere continue to provide new insights into understanding plasma and geophysical proceses. This review describes the heating facilities, past and present, and discusses scientific results from these facilities and associated space missions. Phenomena that have been observed with these facilities are reviewed along with theoretical explanations that have been proposed or are commonly accepted. Gaps or uncertainties in understanding of heating-initiated phenomena are discussed together with proposed science questions to be addressed in the future. Suggestions for improvements and additions to existing facilities are presented including important satellite missions which are necessary to answer the outstanding questions in this field. 相似文献
158.
Yoshikawa M. Morinaga N. Namekawa T. 《IEEE transactions on aerospace and electronic systems》1978,(4):623-629
By the term "m-distributed optical signal" we mean a noise-like optical signal whose envelope (or intensity) fluctuation probability is modeled by Nakagami's "m-distribution." Using the m-distribution which has been widely used as an analytical model of the fading envelope in radio communications, it is shown that one can generally analyze the statistical properties such as the photoelectron count probabilities and error probabilities for the wider class of noise-like optical signals; some numerical results are also given. 相似文献
159.
A Lazcano E Díaz-Villagómez T Mills J Oró 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1995,15(3):345-356
The most frequently invoked explanation for the origin of metabolic pathways is the retrograde evolution hypothesis. In contrast, according to the so-called \"patchwork\" theory, metabolism evolved by the recruitment of relatively inefficient small enzymes of broad specificity that could react with a wide range of chemically related substrates. In this paper it is argued that both sequence comparisons and experimental results on enzyme substrate specificity support the patchwork assembly theory. The available evidence supports previous suggestions that gene duplication events followed by a gradual neoDarwinian accumulation of mutations and other minute genetic changes lead to the narrowing and modification of enzyme function in at least some primordial metabolic pathways. 相似文献
160.
L.B. Tsirulnik T.V. Kuznetsova V.N. Oraevsky 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1997,20(12):2369-2372
A new method of nonlinear spectral analysis (called the method of global minimum: MGM), based on the best presentation (in sense of minimal squares) of a given time data set as a sum of sinusoids whose frequencies, amplitudes and phases are to be determined, has been used to find periodicities in annual Wolf sunspot numbers (W) during the period 1700–1995. The possible future behaviour of the 11-year solar cycle (based on an extrapolation of the calculated model) is also presented. The main characteristics of the 23rd solar cycle are as follows: the W maximum occurs about 2004, with a peak of nearly 220. An unusually large value of W will occur during the 23rd cycle, which should be characterised by the longest maximum, specifically, W will be greater than 100 during the 11-year period from 1997 to 2007. The first sharp rise will occur during the period 1996–1998, the second sharp during 2002–2004. The main features of the 24 year cycle are as follows: the next minimum in W, associated with the 24th solar cycle, should occur in the year 2008 and the maximum in 2014. W is expected to peak at about 180. The minimum value for the 25th year cycle is expected to occur in the year 2019. It is shown that the accuracy of these predictions depends, first of all, on the extrapolation of the hyperlong harmonic of the calculated polyharmonic model fit of observed annual sunspot numbers during the period 1700–1995. The error bars in the definition of the maximum and minimum epochs can be as large as two years. 相似文献