The properties of alamethicin incorporated into planar lipid bilayers under the influence of microgravity.

During evolution, life on earth had adapted to the gravity of 1g. Due to space flight, in the last decades the question arose what happens to the brain under microgravity on the molecular level. Ion channels among others are the molecular basis of brain function. Therefore, the investigation of ion channel function under microgravity seems to be a promising approach to gather knowledge on brain function during space flight. In a first step, the ion channel forming peptide Alamethicin was used as a model channel in an artificial membrane. It is well suitable for this kind of investigation, since its properties are well described under standard gravity. For that reason, changes due to microgravity can be detected easily. All experiments were performed in the German drop tower at ZARM-FAB, Bremen. A special set-up was constructed based on the bilayer technique introduced by Mueller and Rudin. All functions of this set-up can be observed and controlled remotely. In the first set of experiments, a dramatic change of electrical properties of Alamethicin under microgravity could be observed. Mainly, the pore frequency is significantly reduced.     

Prediction of solar particle event proton doses using early dose rate measurements

A methodology for predicting solar particle event doses using Bayesian inference is being developed. As part of this development, we have tested criteria for categorization of new solar particle events (SPE) using calculated asymptotic doses and dose rates for the 22 SPEs that occurred in 2001. In 9 out of 22 events, our criteria for categorization would have over-predicted the range of asymptotic doses in which the tested events would have fallen. In two cases, our methodology under-predicted the dose range in which the event would have fallen. In order to better predict a new event's group category and thus, to better restrict the Bayesian inference predictive model parameter space, we have reexamined our dose rate criteria for categorization of new events. We report the updating of the grouping criteria using data from the 22 SPEs of 2001, as well as five additional SPEs. Using the revised grouping criteria, we present an analysis of group categorization prediction results for the first ten SPEs of 2002.     

Infrared sensor for hot spot recognition for a small satellite mission

High temperature events strongly influence the environmental processes. Therefore, their observation is an important constituent of the global monitoring network. Unfortunately the current remote sensing systems are not able to deliver the necessary information about the world wide burn out of vegetation and its consequences. For global observations a dedicated system of small satellites is required. The main components of the corresponding instrumentation are the infrared channels. The proposed HSRS (HOT SPOT RECOGNITION SENSOR) has to demonstrate the possibilities of an such instrumentation and its feasibility for small satellites. The main drawbacks of the HSRS design are the handling of the hot spot recognition in the subpixel area and of the saturation in the case of larger hot areas by a suitable signal processing hardware.     

STARDUST: finessing expensive cometary sample returns

The STARDUST Discovery mission will collect samples of cometary coma and interstellar dust and return them to Earth. Five years after launch in February 1999, coma dust in the 1- to 100-micrometers size range will be captured by impact into ultra-low-density silica aerogel during a 6 kms-1 flyby of Comet Wild 2. The returned samples will be investigated at laboratories where the most critical information on these primitive materials is retained. The Jet Propulsion Laboratory will provide project management with Lockheed Martin Astronauts as the spacecraft industrial partner. STARDUST management will aggressively and innovatively achieve cost control through the use of Total Quality Management principles, the chief of which will be organization in a Project Engineering and Integration Team that "flattens" the traditional hierarchical structure by including all project elements from the beginning, in a concurrent engineering framework focusing on evolving Integrated Mission Capability.     

Inductive interaction of electroconductive bodies with ionospheric and interplanetary plasma

The hypersonic hyperalfvèn plasma flow around electroconductive bodies is considered and electromagnetic inductive plasma-body interaction is analyzed. The possible applications of results obtained in this analysis to body motion in ionosphere and interplanetary plasma are discussed.     

Communications transponder performance for Japanese Communications Satellite-2 and prospects for future systems

Communications transponder for the Japanese Communications Satellite-2 (CS-2a and 2b) to be launched into a geostationary orbit by N-II launch vehicle in February and August, 1983, has been developed. The transponder is provided with six-channel K-band ($\text{30}\text{20}\text{GHz}$) transponder including beacon transmitter, which operates in the highest frequency ranges ever utilized on an operational communications satellite, and two-channel C-band ($\text{6}\text{4}\text{GHz}$) transponder. Receiver front end of the K-band transponder consists of a direct mixer followed by a 1.8 GHz IF amplifier and provides 8 dB noise figure. 20 GHz output power is 4 W by final amplification at 5-W TWTA. C-band transponder provides 4 dB noise figure and 4.3-W output power. Key factors for future high capacity transponder are also presented.     

Experimental investigation of the modes of operation of uncontrolled attitude motion of the Progress spacecraft

Results of in-flight tests of three modes of uncontrolled attitude motion of the Progress spacecraft are described. These proposed modes of experiments related to microgravity are as follows: (1) triaxial gravitational orientation, (2) gravitational orientation of the rotating satellite, and (3) spin-up in the plane of the orbit around the axis of the maximum moment of inertia. The tests were carried out from May 24 to June 1, 2004 onboard the spacecraft Progress M1-11. The actual motion of this spacecraft with respect to its center of mass, in the above-mentioned modes, was determined by telemetric information about an electric current tapped off from solar batteries. The values of the current obtained during a time interval of several hours were processed jointly using the least squares method by integration of the equations of the spacecraft’s attitude motion. The processing resulted in estimation of the initial conditions of motion and of the parameters of mathematical models used. For the obtained motions the quasi-static component of microaccelerations was computed at a point onboard, where installation of experimental equipment is possible.     

Measuring performance: Moving NASA Earth science products into the mainstream user community

Demonstrating performance of the applications of Earth observation satellite-based science data products and services is increasingly a requirement of government research agencies. We present efforts from the NASA-funded Earth Observing System Data and Information System's Synergy Project to measure performance in the development of applications from NASA research and development projects. We summarize challenges in monitoring performance and share our experience in evolving metrics over a 5-year project life. We demonstrate how to adapt project management processes and metrics from the information technology (IT) industry to Earth observation applications research and development. A roadmap for adapting IT processes and developing metrics and examples of quantitative and qualitative metrics are provided. Our findings suggest that designing and implementing these IT metrics will enhance project success, as defined by the degree of penetration of NASA products into the user community and level of non-NASA funding secured.     

The dynamics of blood biochemical parameters in cosmonauts during long-term space flights

Most of the previously obtained data on cosmonauts' metabolic state concerned certain stages of the postflight period. In this connection, all conclusions, as to metabolism peculiarities during the space flight, were to a large extent probabilistic. The purpose of this work was study of metabolism characteristics in cosmonauts directly during long-term space flights. In the capillary blood samples taken from a finger, by "Reflotron IV" biochemical analyzer, "Boehringer Mannheim" GmbH, Germany, adapted to weightlessness environments, the activity of GOT, GPT, CK, gamma-GT, total and pancreatic amylase, as well as concentration of hemoglobin, glucose, total bilirubin, uric acid, urea, creatinine, total, HDL- and LDL cholesterol, triglycerides had been determined. HDL/LDL-cholesterol ratio also was computed. The crewmembers of 6 main missions to the "Mir" orbital station, a total of 17 cosmonauts, were examined. Biochemical tests were carried out 30-60 days before launch, and in the flights different stages between the 25-th and the 423-rd days of flights. In cosmonauts during space flight had been found tendency to increase, in compare with basal level, GOT, GPT, total amylase activity, glucose and total cholesterol concentration, and tendency to decrease of CK activity, hemoglobin, HDL-cholesterol concentration, and HDL/LDL - cholesterol ratio. Some definite trends in variations of other determined biochemical parameters had not been found. The same trends of mentioned biochemical parameters alterations observed in majority of tested cosmonauts, allows to suppose existence of connection between noted metabolic alterations with influence of space flight conditions upon cosmonaut's body. Variations of other studied blood biochemical parameters depends on, probably, pure individual causes.     

Application of the mechanical oscillator technique to the investigation of EVA decompression

The ultrasonic bubble detection technique has been used as a versatile tool in the investigation of hypobaric decompression procedures for the last two decades. However, this method can only detect relatively large bubbles > 30-50 micrometers (usually in venous blood) and not the very first stages of bubble formation. Recently, the mechanical oscillator technique has been applied in air diving trials in order to detect small blood density changes due to hypothetical fluid shifts. However, sharp density drops were found in the decompression process, and these have been attributed to gas bubble formation. In this study, this method was applied together with Doppler controls to a series of altitude decompressions to 300 and 500 hPa, which represents the range of EVA operational pressures currently used or planned. Six subjects participated in both series; the oscillator sample tube could be pressurized. By the application of pressure on a blood sample containing questionable gas bubbles, these are reduced in volume, like in recompression therapy, and thus the density of the sample is increased. This effect has been shown in all 6 subjects undergoing decompression to 300 hPa, whereas in the 500 hPa series only 3 out of 6 subjects corresponded with gas phase formation immediately after decompression. Typically, Doppler bubbles appeared only after some latency time between 20 and 60 min; after this time, the density effect had nearly vanished. It is concluded that the mechanical oscillator technique represents a complementary research instrument to the Doppler method, because it is able to deliver a quantitative resolution of the early stage of gas phase formation.