Effects of microgravity on c-fos gene expression in osteoblast-like MC3T3-E1 cells.

The paper summarizes the data on proliferation and gravity-related gene expression of osteoblasts that were obtained from an experiment conducted under simulated and real microgravity conditions. Simulated microgravity conditions obtained in a clinostat depress proliferation of both osteoblast-like MC3T3-E1 and HeLa carcinoma cells. This depression of proliferation occurs in a collagen gel culture in which the flow of culture medium by rotation may be reduced. Interestingly, MC3T3-E1 cells which are probably one of target cells to microgravity are more sensitive than the HeLa cells. Simulated microgravity inhibited the epidermal growth factor (EGF)-induced c-fos gene expression in the MC3T3-El cells. To examine in detail the effect of real microgravity on the EGF signal transduction cascade in osteoblasts, MC3T3-E1 cells were cultured in the Cell Culture Experiment Module of the sounding rocket TR-1A6. The EGF-induced c-fos expression in cells was depressed under short-term microgravity conditions in the sounding rocket, while the phosphorylation of mitogen-activated protein kinase (MAPK) was not affected compared with the controls grown on the ground. These results suggest that an action site of microgravity in the signal transduction pathway may be downstream of MAPK.     

Beagle 2: a proposed exobiology lander for ESA's 2003 Mars Express mission.

The aim of the proposed Beagle 2 small lander for ESA's 2003 Mars Express mission is to search for organic material on and below the surface of Mars and to study the inorganic chemistry and mineralogy of the landing site. The lander will have a total mass of 60kg including entry, descent, and landing system. Experiments will be deployed on the surface using a robotic arm. It will use a mechanical mole and grinder to obtain samples from below the surface, under rocks, and inside rocks. Sample analysis by a mass spectrometer will include isotopic analysis. An optical microscope, an X-ray spectrometer and a Mossbauer spectrometer will conduct in-situ rock studies.     

The Solar Isotope Spectrometer for the Advanced Composition Explorer

The Solar Isotope Spectrometer (SIS), one of nine instruments on the Advanced Composition Explorer (ACE), is designed to provide high- resolution measurements of the isotopic composition of energetic nuclei from He to Zn (Z=2 to 30) over the energy range from ∼10 to ∼100 MeV nucl−1. During large solar events SIS will measure the isotopic abundances of solar energetic particles to determine directly the composition of the solar corona and to study particle acceleration processes. During solar quiet times SIS will measure the isotopes of low-energy cosmic rays from the Galaxy and isotopes of the anomalous cosmic-ray component, which originates in the nearby interstellar medium. SIS has two telescopes composed of silicon solid-state detectors that provide measurements of the nuclear charge, mass, and kinetic energy of incident nuclei. Within each telescope, particle trajectories are measured with a pair of two-dimensional silicon-strip detectors instrumented with custom, very large-scale integrated (VLSI) electronics to provide both position and energy-loss measurements. SIS was especially designed to achieve excellent mass resolution under the extreme, high flux conditions encountered in large solar particle events. It provides a geometry factor of ∼40 cm2 sr, significantly greater than earlier solar particle isotope spectrometers. A microprocessor controls the instrument operation, sorts events into prioritized buffers on the basis of their charge, range, angle of incidence, and quality of trajectory determination, and formats data for readout by the spacecraft. This paper describes the design and operation of SIS and the scientific objectives that the instrument will address. This revised version was published online in June 2006 with corrections to the Cover Date.     

Improvement of forebody/inlet integration for hypersonic vehicle

Results of a numerical (CFD) study of the influence of the forebody shape on local flow parameters at a bottom-mounted inlet entrance are presented. The free-stream Mach number is assumed to be 3.5–7.0. Some recommendations on forebody shape optimization are provided. Main characteristics of the air inlet are evaluated.     

Communications and radio determination system using twogeostationary satellites. I. System and experiments

We developed two types of hybrid terminals that can provide both satellite communication and position determination services in one system. One terminal uses the single channel per carrier (SCPC) technique and the other uses the spread spectrum (SS) technique. To evaluate the performance of the two systems, we carried out experiments in Japan and in the Pacific Ocean using two geostationary satellites, ETS-V (150°E) and Inmarsat (180°E). The ranging accuracy between the mobile terminals and the base station via the satellites was found to be about 200 m using the SCPC system and about 10 m using the SS system. The measured positioning accuracy was about 1 km in the SCPC system and about 600 m in the SS system when experiments were carried out near Japan. The experimental results show that the positioning errors were mainly caused by the orbital determination errors of the two satellites. Presented here are the configurations and features of the SCPC and SS terminals, the experimental system, and the experimental results     

A method of technologic audit of technical re-equipment projects in aircraft production enterprises

A method of technologic audit for technical re-equipment of enterprises is considered. The method developed is intended to verify technological solutions of projects of technical re-equipment of enterprises according to indicators of productivity.     

Definition of Wingtip Devices Shape and Dimensions for a Subsonic Airliner

The results of flow field numerical simulation on the typical wing-body prototype of the modern DLR-F4 airliner under sub- and transonic compressible air flow are presented. Using the DLR-F4 CAD model, the effect of the wingtip end plate area and of the cant angle of a typical Whitcomb winglet is studied. The dependencies of the model lift-to-drag ratio increment on the flat wingtip end plate relative area and on the cant angle of an airfoil Whitcomb winglet are obtained. The concept of an elliptic winglet with a variable cant angle that similar to the winglet used on Airbus A350 is studied. A technique is developed for solving the multi-parameter design optimization task for the Whitcomb winglet, taking the maximum lift-to-drag ratio of the wing as a criterion for optimization.     

Parametric Identification of a Return Space Vehicle during Vertical Landing

Real values of parameters for a space vehicle and its steering devices are specified by using the motion parameters measured in flight based on solving the differential equations of motion.     

Near-infrared study of open clusters Teutsch 10 and Teutsch 25

The astrophysical parameters have been estimated for two unstudied open star clusters Teutsch 10 and Teutsch 25 using the Two Micron All Sky Survey ($2\mathit{MASS}$) database. Radius is estimated as 4.5 arcmin for both clusters using radial density profiles. We have estimated proper motion values in both RA and DEC directions as $2.28\pm 0.3$ and $-0.38\pm 0.11$?mas?yr^?1 for Teutsch 10 and $0.48\pm 0.3$ and $3.35\pm 0.16$?mas?yr^?1 for Teutsch 25 using $\mathit{PPMXL}$¹ catalog. By estimating the stellar membership probabilities, we have identified 30 and 28 most likely members for Teutsch 10 and Teutsch 25 respectively. We have estimated the reddening as $E(B-V)=0.96\pm 0.3$?mag for Teutsch 10 and $0.58\pm 0.2$?mag for Teutsch 25, while the corresponding distances are $2.4\pm 0.2$ and $1.9\pm 0.1$?kpc. Ages of $70\pm 10$?Myr for Teutsch 10 and $900\pm 100$?Myr for Teutsch 25 are estimated using the theoretical isochrones of metallicity Z?=?0.019. The mass function slopes are derived as $1.23\pm 0.30$ and $1.09\pm 0.35$ for Teutsch 10 and Teutsch 25 respectively. Estimated mass function slope for both the clusters are close to the Salpeter value ($x=1.35$) within the errors. Estimated values of dynamical relaxation time are found to be less than cluster’s age for these objects. This concludes that both objects are dynamically relaxed. The possible reason for relaxation may be due to dynamical evolution or imprint of star formation or both.     

Behavior of tethered debris with flexible appendages

Active exploration of the space leads to growth of a near-Earth space pollution. The frequency of the registered collisions of space debris with functional satellites highly increased during last 10 years. As a rule a large space debris can be observed from the Earth and catalogued, then it is possible to avoid collision with the active spacecraft. However every large debris is a potential source of a numerous small debris particles. To reduce debris population in the near Earth space the large debris should be removed from working orbits. The active debris removal technique is considered that intend to use a tethered orbital transfer vehicle, or a space tug attached by a tether to the space debris. This paper focuses on the dynamics of the space debris with flexible appendages. Mathematical model of the system is derived using the Lagrange formalism. Several numerical examples are presented to illustrate the mutual influence of the oscillations of flexible appendages and the oscillations of a tether. It is shown that flexible appendages can have a significant influence on the attitude motion of the space debris and the safety of the transportation process.