Life before RNA

The hypothesis that life originated and evolved from linear informational molecules capable of facilitating their own catalytic replication is deeply entrenched. However, widespread acceptance of this paradigm seems oblivious to a lack of direct experimental support. Here, we outline the fundamental objections to the de novo appearance of linear, self-replicating polymers and examine an alternative hypothesis of template-directed coding of peptide catalysts by adsorbed purine bases. The bases (which encode biological information in modern nucleic acids) spontaneously self-organize into two-dimensional molecular solids adsorbed to the uncharged surfaces of crystalline minerals; their molecular arrangement is specified by hydrogen bonding rules between adjacent molecules and can possess the aperiodic complexity to encode putative protobiological information. The persistence of such information through self-reproduction, together with the capacity of adsorbed bases to exhibit enantiomorphism and effect amino acid discrimination, would seem to provide the necessary machinery for a primitive genetic coding mechanism.     

Eye light flashes on the Mir space station

The phenomenon of light flashes (LF) in eyes for people in space has been investigated onboard Mir. Data on particles hitting the eye have been collected with the SilEye detectors, and correlated with human observations. It is found that a nucleus in the radiation environment of Mir has roughly a 1% probability to cause an LF, whereas the proton probability is almost three orders of magnitude less. As a function of LET, the LF probability increases above 10 keV/micrometer, reaching about 5% at around 50 keV/micrometer.     

Lunar polar ice deposits: scientific and utilization objectives of the Lunar Ice Discovery Mission proposal

The Clementine mission has revived interest in the possibility that ice exists in shadowed craters near the lunar poles. Theoretically, the problem is complex, with several possible sources of water (meteoroid, asteroid, comet impact), several possible loss mechanisms (impact vaporization, sputtering, photoionization), and burial by meteorite impact. Opinions of modelers have ranged from no ice to several times 10(16) g of ice in the cold traps. Clementine bistatic radar data have been interpreted in favor of the presence of ice, while Arecibo radar data do not confirm its presence. The Lunar Prospector mission, planned to be flown in the fall of 1997, could gather new evidence for the existence of ice. If ice is present, both scientific and utilitarian objectives would be addressed by a lunar polar rover, such as that proposed to the NASA Discovery program, but not selected. The lunar polar rover remains the best way to understand the distribution and characteristics of lunar polar ice.     

Study of cosmic rays and light flashes on board Space Station MIR: the SilEye experiment.

The SilEye experiment aims to study the cause and processes related to the anomalous Light Flashes (LF) perceived by astronauts in orbit and their relation with Cosmic Rays. These observations will be also useful in the study of the long duration manned space flight environment. Two PC-driven silicon detector telescopes have been built and placed aboard Space Station MIR. SilEye-1 was launched in 1995 and provided particles track and LF information; the data gathered indicate a linear dependence of FLF(Hz) ( 4 2) 10(3) 5.3 1.7 10(4) Fpart(Hz) if South Atlantic Anomaly fluxes are not included. Even though higher statistic is required, this is an indication that heavy ion interactions with the eye are the main LF cause. To improve quality and quantity of measurements, a second apparatus, SilEye-2, was placed on MIR in 1997, and started work from August 1998. This instrument provides energetic information, which allows nuclear identification in selected energy ranges; we present preliminary measurements of the radiation field inside MIR performed with SilEye-2 detector in June 1998.     

Halo White Dwarfs and Baryonic Dark Matter

We describe the formation of hot intergalactic gas along with baryonic remnants in galaxy halos. In this scenario, the mass and metallicity of the hot intracluster and intragroup gas relates directly to the production of baryonic remnants during the collapse of galactic halos. We construct a schematic but self-consistent model in which early bursts of star formation lead to a large remnant population in the halo, and to the outflow of stellar ejecta into the halo and ultimately the Local Group. We consider local as well as high redshift constraints on this scenario. This study suggests that the microlensing objects in the Galactic halo may predominantly be 0.5M white dwarfs, assuming that the initial mass function for early star formation favored the formation of intermediate mass stars with m 1M. However, the bulk of the baryonic dark matter in this scenario is associated with the ejecta of the white dwarf progenitors, and resides in the hot intergalactic medium.     

The sopite syndrome revisited: drowsiness and mood changes during real or apparent motion

The sopite syndrome is a poorly understood response to motion. Drowsiness and mood changes are the primary characteristics of the syndrome. The sopite syndrome can exist in isolation from more apparent symptoms such as nausea, can last long after nausea has subsided, and can debilitate some individuals. It is most likely a distinct syndrome from "regular" motion sickness or common fatigue, and is of potential concern in a variety of situations. The syndrome may be particularly hazardous in transportation settings where other performance challenges (e.g., sleep deprivation) are already present. It is also a potential concern in cases where illnesses such as sleep disorders or depression may interact with the syndrome and confuse diagnosis.     

Cognitive performance aboard the life and microgravity spacelab

The impact of microgravity and other stressors on cognitive performance need to be quantified before long duration space flights are planned or attempted since countermeasures may be required. Four astronauts completed 38 sessions of a 20-minute battery of six cognitive performance tests on a laptop computer. Twenty-four sessions were preflight, 9 sessions were in-orbit, and 5 sessions were postflight. Mathematical models of learning were fit to each subject's preflight data for each of 14 dependent variables. Assuming continued improvement, expected values were generated from the models for in-orbit comparison. Using single subject designs, two subjects showed statistically significant in-orbit effects. One subject was degraded in two tests, the other was degraded in one test and exceeded performance expectations in another. Other subjects showed no statistically significant effects on the tests. The factors causing the deterioration in the two subjects can not be determined without appropriate ground-based control groups.     

Prolonged weightlessness, reference frames and visual symmetry detection

We evaluated the influence of prolonged weightlessness on the performance of three cosmonauts to bilateral symmetry detection in the course of a 15-day-long Russian-French mission CASSIOPEE 96 aboard the MIR station. We tested the influence of weightlessness on subjects' performance as a function of the retinal orientation of axis of symmetry. as a function of type of stimuli (closed versus multi-elements shapes) and as a function of visual field presentation (at fixation, left visual field. right visual field). The results indicate firstly a difference between presentation at fixation versus away of fixation. Away of fixation, no effect of microgravity on performance was shown. A hypothesis of hemispheric specialization for symmetry detection was not supported as well. At fixation, an effect of micro-gravity was shown and more interestingly, the effect was quite different as a function of type of shapes used. suggesting that symmetry detection is a multiple-stage process.     

Cellular responses to gravity: extracellular, intracellular and in-between.

Our understanding of gravitational effects (inertial effects in the vicinity of 1 x g) on cells has matured to a stage at which it is possible to define, on the basis of experimental evidence, extracellular effects on small cells and intracellular effects on eukaryotic gravisensing cells. Yet undetermined is the nature of response, if any, of those classes of cells that are not governed solely by extracellular physical events (as are prokaryotes) and are devoid of obvious mechanical devices for sensing inertial forces (such as those possessed by certain plant cells and sensory cells of animals). This "in-between" class of cells needs to be understood on the basis of the combination of intracellular and extracellular gravity-dependent processes that govern experimentally-measurable variables that are relevant to the cell's responses to modified inertial forces. The forces that certain cell types generate or respond to are therefore compared to those imposed by approximately 1 x g in the context of cytoskeletal action and symmetry-breaking pathways.