Thyrotropin receptor and membrane interactions in FRTL-5 thyroid cell strain in microgravity

The aim of this work was to analyze the possible alteration of thyrotropin (TSH) receptors in microgravity, which could explain the absence of thyroid cell proliferation in the space environment. Several forms of the TSH receptor are localized on the plasma membrane associated with caveolae and lipid rafts. The TSH regulates the fluidity of the cell membrane and the presence of its receptors in microdomains that are rich in sphingomyelin and cholesterol. TSH also stimulates cyclic adenosine monophosphate (cAMP) accumulation and cell proliferation. Reported here are the results of an experiment in which the FRTL-5 thyroid cell line was exposed to microgravity during the Texus-44 mission (launched February 7, 2008, from Kiruna, Sweden). When the parabolic flight brought the sounding rocket to an altitude of 264?km, the culture media were injected with or without TSH in the different samples, and weightlessness prevailed on board for 6 minutes and 19 seconds. Control experiments were performed, in parallel, in an onboard 1g centrifuge and on the ground in Kiruna laboratory. Cell morphology and function were analyzed. Results show that in microgravity conditions the cells do not respond to TSH treatment and present an irregular shape with condensed chromatin, a modification of the cell membrane with shedding of the TSH receptor in the culture medium, and an increase of sphingomyelin-synthase and Bax proteins. It is possible that real microgravity induces a rearrangement of specific sections of the cell membrane, which act as platforms for molecular receptors, thus influencing thyroid cell function in astronauts during space missions.     

Economy of modular low-technology launch vehicles

The paper comprises an assessment of the design and the economics of so-called “low-cost” simple modular launch vehicles. It is shown that the performance is very marginal and that the cost per launch cannot compete with technically more advanced fully reusable vehicles. Especially a private-funded development cannot be amortized economically in case of an expendable launch vehicle.     

Preliminary calibration results of VEGA 1 and 2 SIGMA-3 gas chromatograph

SIGMA - 3 gas chromatograph on board VEGA 1 and 2 landing probes has been operated successfully in the 60 - 50 km altitude range, providing several in - situ chemical analysis of the gas and the aerosols of Venus cloud layers. Post flight calibration required to derive atmospheric abundancies from gas chromatograms were carried out using the SIGMA - 3 spare model. A Venus atmospheric aerosol simulation chamber was used in which sulfuric acid droplets were generated. Preliminary results of these calibration experiments indicate that the concentration of sulfuric acid in the upper part of the clouds ( 60 to 55 km) is about 1 mg/m³ and suggest that an additional constituant must be present in noticeable amount in the aerosols. From these experiments the mixing ratio upper limits of SO₂ is 100 ppmV and of H₂S and COS is few 10 ppmV.     

Constant-False-Alarm-Rate Processors for Locally Nonstationary Clutter

A technique for designing normalizing processors for locally non-stationary clutter is discussed. The design procedure assumes the logarithm of the clutter power varies as a polynomial with range. When the actual environment matches the design environment, the false-alarm rate is a constant that is independent of the polynomial coefficients. A measure of the relative target detection capability as a function of the number of normalization cells and the degree of the design-environment polynomial is given. The applicability of the processors to non-Rayleigh clutter is discussed.     

The Circular Synthetic Radar

A new type of synthetic radar, the circular synthetic radar, uses a simple interferometer whose elements are mounted at the ends of a horizontal boom rotating about a vertical mast. Pulses are radiated alternately ?in-phase? and in ?phase-quadrature.? The returning echoes are also detected incoherently, both ?in-phase? and in ?phase-quadrature.? The four distinct outputs are fed into an on-line computer which, after a Fourier analysis, synthesizes a mapping function of the azimuthal distribution of targets.     

Analysis of Multimodal Systems

The estimation of a multimodal linear system whose mode-to-mode transitions are described by a finite-state Markov chain is described. The problem has application in studying separation standards in an air traffic control environment. An optimal solution is formulated which is computationally infeasible. A suboptimal estimator is then derived which closely approximates the optimal estimator. An example is presented to illustrate the technique.     

Optical Design for a Cubesat: Unobscured Telescope,Using Freeform Mirrors and a Curved Detector

The possibility of constructing an optical scheme of a telescope for a small satellite based on mirrors with freeform surfaces and a curved photodetector is considered. It is shown that the use of a new element base allows the effective area of the main mirror to be maximized and the field of view up to 9.4 times to be increased in comparison with the classical scheme of the Ritchey–Chretien scheme in ensuring the high image quality.     

Summary of quantitative interpretation of IMAGE far ultraviolet auroral data

Direct imaging of the magnetosphere by instruments on the IMAGE spacecraft is supplemented by simultaneous observations of the global aurora in three far ultraviolet (FUV) wavelength bands. The purpose of the multi-wavelength imaging is to study the global auroral particle and energy input from the magnetosphere into the atmosphere. This paper describes the method for quantitative interpretation of FUV measurements. The Wide-Band Imaging Camera (WIC) provides broad band ultraviolet images of the aurora with maximum spatial resolution by imaging the nitrogen lines and bands between 140 and 180 nm wavelength. The Spectrographic Imager (SI), a dual wavelength monochromatic instrument, images both Doppler-shifted Lyman-α emissions produced by precipitating protons, in the SI-12 channel and OI 135.6 nm emissions in the SI-13 channel. From the SI-12 Doppler shifted Lyman-α images it is possible to obtain the precipitating proton flux provided assumptions are made regarding the mean energy of the protons. Knowledge of the proton (flux and energy) component allows the calculation of the contribution produced by protons in the WIC and SI-13 instruments. Comparison of the corrected WIC and SI-13 signals provides a measure of the electron mean energy, which can then be used to determine the electron energy flux. To accomplish this, reliable emission modeling and instrument calibrations are required. In-flight calibration using early-type stars was used to validate the pre-flight laboratory calibrations and determine long-term trends in sensitivity. In general, very reasonable agreement is found between in-situ measurements and remote quantitative determinations.     

Radar target classification of commercial aircraft

With the increased availability of coherent wideband radars there has been a renewed interest in radar target recognition. A large bandwidth gives high resolution in range which means target discrimination may be possible. Coherence makes cross-range resolution and radar images possible. Some of the problems of classifying high resolution range profiles (HRRPs) are examined and simple preprocessing techniques which may aid subsequent target classification are investigated. These techniques are applied to HRRP data acquired at a local airport using the Microwave Radar Division (MRD) mobile radar facility It is found that Boeing 727 and Boeing 737 aircraft can be reliably distinguished over a range of aspect angles. This augers well for future target classification studies using HRRPs