Effect of track structure and radioprotectors on the induction of oncogenic transformation in murine fibroblasts by heavy ions

The oncogenic potential of high-energy ⁵⁶Fe particles (1 GeV/nucleon) accelerated with the Alternating Gradient Synchrotron at the Brookhaven National Laboratory was examined utilizing the mouse C3H 10T1/2 cell model. The dose-averaged LET for high-energy ⁵⁶Fe is estimated to be 143 keV/μm with the exposure conditions used in this study. For ⁵⁶Fe ions, the maximum relative biological effectiveness (RBE_max) values for cell survival and oncogenic transformation were 7.71 and 16.5 respectively. Compared to 150 keV/μm ⁴He nuclei, high-energy ⁵⁶Fe nuclei were significantly less effective in cell killing and oncogenic induction. The prostaglandin E₁ analog misoprostol, an effective oncoprotector of C3H 10T1/2 cells exposed to X rays, was evaluated for its potential as a radioprotector of oncogenic transformation with high-energy ⁵⁶Fe. Exposure of cells to misoprostol did not alter ⁵⁶Fe cytotoxicity or the rate of ⁵⁶Fe-induced oncogenic transformation.     

Design of the HEAO Main Bus Shunt Regulator

The High Energy Astronomy Observatory (HEAO) main bus regulator contains a redundant error amplifier (REA) and a 12-section sequenced shunt transconductance amplifier (STA) in which not more than three and not less than one shunt section are in an active control mode regardless of a failure in any one of the twelve sections. The part of the work concerned with the shaping of the frequency response of the REA and STA minor feedback loops and of the teolator major feedback loop is described. Emphasis is on the application of a general design technique embodying a "design-analyze-measure iteration loop," in which a first-cut design and analysis is corrected ard improved after experimental observation of discrepancies and deficiencies. In particular, an incipient high-frequency oscillation was thereby reliably eliminated. It is demonstrated that analysis techniques involving a minimum of algebra can provide full quantitative information on an efficient and reliable system design.     

A new distributed constant false alarm rate detector

A new constant false alarm rate (CFAR) test termed signal-plus-order statistic CFAR (S+OS) using distributed sensors is developed. The sensor modeling assumes that the returns of the test cells of different sensors are all independent and identically distributed In the S+OS scheme, each sensor transmits its test sample and a designated order statistic of its surrounding observations to the fusion center. At the fusion center, the sum of the samples of the test cells is compared with a constant multiplied by a function of the order statistics. For a two-sensor network, the functions considered are the minimum of the order statistics (mOS) and the maximum of the order statistics (MOS). For detecting a Rayleigh fluctuating target in Gaussian noise, closed-form expressions for the false alarm and detection probabilities are obtained. The numerical results indicate that the performance of the MOS detector is very close to that of a centralized OS-CFAR and it performs considerably better than the OS-CFAR detector with the AND or the OR fusion rule. Extension to an N-sensor network is also considered, and general equations for the false alarm probabilities under homogeneous and nonhomogeneous background noise are presented.