DNA damage and repair in oncogenic transformation by heavy ion radiation.

Energetic heavy ions are present in galactic cosmic rays and solar particle events. One of the most important late effects in risk assessment is carcinogenesis. We have studied the carcinogenic effects of heavy ions at the cellular and molecular levels and have obtained quantitative data on dose-response curves and on the repair of oncogenic lesions for heavy particles with various charges and energies. Studies with repair inhibitors and restriction endonucleases indicated that for oncogenic transformation DNA is the primary target. Results from heavy ion experiments showed that the cross section increased with LET and reached a maximum value of about 0.02 micrometer2 at about 500 keV/micrometer. This limited size of cross section suggests that only a fraction of cellular genomic DNA is important in radiogenic transformation. Free radical scavengers, such as DMSO, do not give any effect on induction of oncogenic transformation by 600 MeV/u iron particles, suggesting most oncogenic damage induced by high-LET heavy ions is through direct action. Repair studies with stationary phase cells showed that the amount of reparable oncogenic lesions decreased with an increase of LET and that heavy ions with LET greater than 200 keV/micrometer produced only irreparable oncogenic damage. An enhancement effect for oncogenic transformation was observed in cells irradiated by low-dose-rate argon ions (400 MeV/u; 120 keV/micrometer). Chromosomal aberrations, such as translocation and deletion, but not sister chromatid exchange, are essential for heavy-ion-induced oncogenic transformation. The basic mechanism(s) of misrepair of DNA damage, which form oncogenic lesions, is unknown.     

黄海气象海况对海上发射运载火箭的影响

海上发射运载火箭的实施过程会受到气象海洋环境的影响和制约,气象海洋环境会直接影响海上发射窗口期的选择及发射安全。为避免海上发射在复杂气象海况条件下发生设备重大损坏、窗口长期延后和人员安全事故等问题,通过分析黄海海域波浪场、风场、温度场及降水场的分布特征及变化规律,对基于季节变化特征的海上发射实施阶段及季节性预防趋势进行分析总结,为以后在不同季节极端天气下海上发射运载火箭提供参考。     

永磁有限转角力矩电机的仿真与实验

随着多电飞机的快速发展及成附件轻小化、高效能的迫切需求,有限转角力矩电机(Limited Angle Torque Motor,LATM)在飞机引气系统中的应用日益迫切。一方面,有限转角力矩电机可以显著简化高温引气控制阀结构、减小体积;另一方面,可以基于系统需求实现引气压力和温度按需调节,减少燃油代偿损失。针对高温有限转角力矩电机工作特性不易预测的难题,建立了其数学模型、仿真模型,并通过实物试验验证了仿真模型的准确性。研究结果为有限转角力矩电机特性研究提供了参考依据。     

多径信道下基于恒模算法的遥测信号盲均衡

运载火箭在塔架静态测试时易受多径衰落影响,导致遥测信号产生码间干扰。本文对PCM-FM体制遥测信号的多径信道使用恒模算法(CMA)进行盲均衡研究,针对遥测信道中的码间干扰展开理论分析和Matlab仿真,并搭建盲均衡功能测试平台开展实验验证。结果表明:CMA收敛速度高、误码率低,对多径干扰具有较好的鲁棒性和实用性。     

基于基准控制的低压涡轮转静子装测一体化方法

为进行大涵道比航空发动机低压涡轮转子同心度的精确测量与控制,根据其多级耦合的结构特点和0.05 mm转子同心 度的控制需求,开展了基于基准控制的低压涡轮转静子高精度装测一体化方法研究。通过基准调节方法实现测量基准与回转轴 线重合,消除了定位误差;通过基准保持方法避免了装配操作对基准的影响,保证了测量基准姿态的一致性;结合质心对转子不平 衡量的影响,搭建了专用测试系统,实现对低压涡轮转子同心度的装配结果管控。将该方法应用于发动机低压涡轮转静子装配, 结果表明：实现了0.0125 mm转子跳动的精确测量,有效避免了低压涡轮转子初始不平衡量超差,减少了重复装分工作,提高了装 配质量和效率,对多级部件同心度的高精度测量具有工程指导意义。     

蒙皮加筋圆柱壳扭转频率的三种计算模型

为了给火箭等加筋圆柱壳结构的简化计算提供理论基础,研究了加筋圆柱壳面积等效方法中的扭转刚度计算方法,说明了不能直接根据等效厚度计算扭转刚度的物理机理,得到了桁条对圆柱壳扭转刚度的贡献可以忽略的结论.根据等效厚度以及桁条与蒙皮连接关系的不同处理方法,给出了计算扭转固有振动频率的等效梁模型、变厚度壳模型和壳-梁模型,分析了桁条在3种模型中对刚度和质量(包括转动惯量)的不同作用.为了消除根据等效厚度计算扭转刚度和扭转固有振动频率的偏差,分别给出了扭转刚度和扭转固有振动频率的修正方法.数值结果验证了修正方法和所得结论的正确性.      

基于查表的开环MPM预失真器

提出了一种基于查表的开环记忆多项式模型(MPM,Memory Polynomial Model)预失真器.从MPM预失真器系数估计和执行信号预失真处理两方面加以考虑.首先,利用预失真器和高功率放大器(HPA,High Power Amplifier)传输特性的互补性,由采集到的HPA输入、输出基带数据进行单次最小二乘估计得到MPM预失真器的系数,避免了以往递归结构的收敛性和计算量大等问题.然后,利用MPM预失真器的特点,建立了基于输入信号强度索引的一维向量表,通过查表实现MPM预失真器的幂次累加项,极大地减少了实现预失真器所需的计算量及硬件开销.仿真显示,采用提出的预失真器可以有效补偿HPA对信号的记忆非线性失真,有效带宽内获得了近20 dB的功率改善,也显著改善了系统误码性能.     

Coupled Lagrangian impingement spray model for doublet impinging injectors under liquid rocket engine operating conditions

To predict the effect of the liquid rocket engine combustion chamber conditions on the impingement spray, the conventional uncoupled spray model for impinging injectors is extended by considering the coupling of the jet impingement process and the ambient gas field. The new coupled model consists of the plain-orifice sub-model, the jet-jet impingement sub-model and the droplet collision sub-model. The parameters of the child droplet are determined with the jet-jet impingement sub-model using correlations about the liquid jet parameters and the chamber conditions.The overall model is benchmarked under various impingement angles, jet momentum and offcenter ratios. Agreement with the published experimental data validates the ability of the model to predict the key spray characteristics, such as the mass flux and mixture ratio distributions in quiescent air. Besides, impinging sprays under changing ambient pressure and non-uniform gas flow are investigated to explore the effect of liquid rocket engine chamber conditions. First, a transient impingement spray during engine start-up phase is simulated with prescribed pressure profile. The minimum average droplet diameter is achieved when the orifices work in cavitation state, and is about 30% smaller than the steady single phase state. Second, the effect of non-uniform gas flow produces off-center impingement and the rotated spray fan by 38°. The proposed model suggests more reasonable impingement spray characteristics than the uncoupled one and can be used as the first step in the complex simulation of coupling impingement spray and combustion in liquid rocket engines.     

δ相对GH4169合金高温持久性能的影响

研究了δ相对ＧＨ４１６９合金持久性能的影响。结果表明，δ相数量过多或过少都会对合金持久寿命产生不利影响，当δ相数量约为４．８２％时，合金持久寿命达到最大值。     

飞行控制律全包线鲁棒稳定性评估

传统的飞行控制律评估方法只能对飞行包线内的离散点进行逐点分析,对不确定性参数也只考虑了上下界,分析过程缺乏完整性和系统性。针对这些不足,研究了基于一种改进遗传算法的分析方法,该方法将评估准则转化为某个适应度函数,通过对适应度函数寻优以找到最坏情况下的不确定参数组合,在其基础上进行评估并给出评估结果或控制律修改意见。仿真结果表明,该方法能连续地研究多个不确定性参数同时摄动时的飞行包线,克服了传统方法的不足。