Neutral buoyancy and sleep-deprived serum factors alter expression of cytokines regulating osteogenesis

We examined expression of genes associated with cytokine production, and genes implicated in regulating bone metabolism, in bone stromal and osteoblast cells incubated under standard ground conditions and under conditions of neutral buoyancy, and in the presence/absence of serum from normal or sleep-deprived mice. We observed a clear interaction between these two conditions (exposure to neutral buoyancy and serum stimulation) in promoting enhanced osteoclastogenesis. Both conditions independently altered expression of a number of cytokines implicated in the regulation of bone metabolism. However, using stromal cells from IL-1 and TNFx cytokine(r) KO mice, we concluded that the increased bone loss under microgravity conditions was not primarily cytokine mediated.     

Multibeam array designed for use in a maritime system using an OTS platform

The study, based on actual hardware specifically developed for a multibeam array, has been concerned with the definition of a payload compatible with the requirements of a second generation maritime system. The proposed payload designed to operate in an OTS spacecraft has the following performance. 19 beam global coverage, give 70 Maritime channels having 52.4 dB Hz quality in deep fades. Mass of payload incl. antenna, 112 kg; d.c. power consumption, 334 W; Operational life time, 7 yr.     

Enhanced Power Generation of GSS4PS by Optical Solar Reflectors

A novel arrangement is proposed to enhance the power generation capabilities of a gravitationally stabilized solid-state-satellite solar-power station (GSS4PS) spherical solar collector. The unilluminated portion of a GSS4PS is illuminated by employing optical solar reflectors. The different mechanisms required for implementation of this arrangement are already space proven. The detailed study of this arrangement made by the authors reveals that practical realization of this concept will enhance the power generation capability of the GSS4PS and simultaneously reduce the weight per unit power and cost per unit power in GSS4PS spherical solar collectors.     

X-rays from quasars and active galaxies

We review some of the most important theoretical ideas and observations for quasars and the nuclei of active galaxies, and suggest areas of future research. Emphasis is on the nature of the power source, the radiation processes, and the mechanism for formation and collimation of jets. Phenomena that produce X-rays are of particular concern. Particular topics discussed are the observed and expected time variability, the gas supply mechanisms and luminosity evolution, thermal and nonthermal radiation processes, observed and theoretical spectra, criteria for thermalization of electrons and ions, effects of electron-positron pairs on relativistic plasmas, hydrodynamic, electrodynamic and inertial methods for producing and confining jets. We conclude with a list of needed observations.Based on a lecture given at the Goddard Workshop on X-ray Astronomy (October 1981).     

Fragmentation in rotating isothermal protostellar clouds

Summary From the extensive set of numerical calculations briefly described above, it seems apparent that rotating, isothermal gas clouds are unstable to fragmentation under a wide range of conditions. (Caution: This result for isothermal clouds cannot be generalized to all clouds, as is shown, for example, by Boss's analysis [these proceedings] of the stability of collapsing, adiabatic clouds.) It is of importance to note, however, that no fragmentation is apparent during a cloud's initial dynamic collapse toward a disk structure; rather it is the rotationally flattened disk/ring configuration that undergoes fragmentation. This is a considerably different picture of fragmentation than has been presented, for example, by Hoyle (1953).The degree of instability and the mode (ring vs. blob) of fragmentation is sensitive to , but insensitive to . The initial amplitude of a perturbation does not appear to be crucial--fragmentation should occur eventually even for low amplitude initial NAPs.Finally, it is of some interest to know what the properties are of the fragments that break out of these isothermal clouds. Before outlining these properties we emphasize that in this set of calculations we have specifically excited the m = 2 (binary) non-axisymmetric mode; hence we have in some sense suppressed the development of other modes and we have promoted the development of equal mass components in the binary systems. In these evolutions, a typical fragment contained 15% of the initial cloud mass; had a specific angular momentum 25–30% that of the original cloud; had a ratio of spin angular momentum to orbital angular momentum 0.2; and itself had a ratio of thermal to gravitational energy _frag < 0.1. The formation of a binary system has therefore resulted in a conversion of some of the original cloud's spin angular momentum into orbital angular momentum, and has produced protostars with reduced specific angular momenta. It is also evident that each fragment is unstable to further collapse (having low ) under the isothermal assumptions imposed here.     

Selection of a Charging Choke Damping Network

The availability and ease of programming for many computer aided design (CAD) languages permits their use where, formerly, bread boarding or analytical means would have been employed to solve specific circuit analysis problems. One of many available CAD languages is the electronic circuit analysis program (ECAP). The ECAP language is divided into three sections, dc-analysis. acanalysis, and transient analysis. The three modes of ECAP together with fast computer access provide a helpful tool for the design engineer. Following is a typical problem of oscillatory transients encountered in line-type modulators. The solution to the problem is a model of sufficient correlation with the observed oscillation as an aid to find a network which will critically damp the oscillation.     

High-Speed Homopolar Inductor Alternators of Minimum Leakage Reactance

The leakage reactance of the machine is expressed as an equation involving slot leakage, end-connection leakage, differential leakage, stator-halves leakage, and tooth-top leakage reactance. This leakage reactance equation, or objective function, is then minimized under suitable constraints. Geometric programming is used to carry through the optimization procedure. A computer program is developed and applied to find the optimum leakage reactance for a 95 kVA, 208 V, wye-connected, 40 800 r/min aerospace alternator, using 8-, 10-, and 12-pole machines.     

Space radiation dosimetry with active detections for the scientific program of the second Bulgarian cosmonaut on board the Mir space station.

A dosimetry-radiometry system has been developed at the Space Research Institute of the Bulgarian Academy of Science to measure the fluxes and dose rates on the flight of the second Bulgarian cosmonaut. The dosimetry system is designed for monitoring the different space radiations, such as solar cosmic rays, galactic cosmic rays and trapped particles in the earth radiation belts. The system consists of a battery operated small size detector unit and a "read-write" and telemetry microcomputer unit. The sensitivity of the instrument (3.67 x 10(-8) rad/pulse) permits high resolution measurements of the flux and dose rate along the track of the Mir space station. We report our initial results for the period of the flight between the 7th and 17th June 1988.     

Infrared astronomy

This review paper is a survey of infrared astronomy up to early 1969. The techniques and photometric standards are mentioned briefly, and results cover solar, lunar, and planetary observations. Point sources and extended sources both within and beyond the Galaxy are included, ending with the problem of cosmic background radiation. It is concluded that great progress will be possible when large infrared telescopes are placed above the atmosphere in orbit for extended periods of time.This work was conducted under the McDonnell Douglas Corporation Independent Research and Development Program.     

Human dimensions in space development

Space exploration is now moving beyond the stage when technical development dominated research. As thinking shifts towards the problems of long-term colonization of the Solar System, the biological and behavioural sciences must make major contributions. This article outlines some of the issues which must be addressed, such as group behaviour and dynamics in space flight, the environment created at space stations and other outposts, recruitment and training of suitable spacefarers, and the planning and governing of space settlements. Ten dimensions of the human aspect of space habitation are described and an indication given of how they may form the basis for a new taxonomy of space planning, operations and management.