Theoretical consideration of the chemical pathways for radiation-induced strand breaks.

A theoretical approach to the understanding of the biochemical mechanisms of indirect action of ionizing radiation on SV40 DNA in aqueous solution is presented. The extent of OH attack on the sugar moiety and bases has been calculated. A realistic model for the DNA (in B form) based on available X-ray diffraction data is used and specific reaction sites for the OH radicals are obtained. A Monte Carlo scheme is used to follow the diffusion and reaction of the OH radicals. Effects of track structure have been considered and the single strand break D37 values for 14 MeV electrons (low-LET) and 670 MeV/u and 40 MeV/u neon particles are presented. Calculated results are in agreement with available experimental data. It has been found that regardless of the qualities of radiation, 80% of the OH attack on DNA is on the bases and 20% is on the deoxyribose. From probability considerations only, it appears that the number of double strand breaks varies linearly with dose.     

Growth and development of cultured carrot cells and embryos under spaceflight conditions

Morphogenetically competent proembryonic cells and well-developed somatic embryos of carrot at two levels of organization were exposed for 18.5 days to a hypogravity environment aboard the Soviet Biosatellite Cosmos 1129. It was confirmed that cultured totipotent cells of carrot can give rise to embryos with well-developed roots and minimally developed shoots. It was also shown that the space hypogravity environment could support the further growth of already-organized, later somatic embryonic stages and give rise to fully developed embryo-plantlets with roots and shoots.     

Neutral buoyancy and sleep-deprived serum factors alter expression of cytokines regulating osteogenesis

We examined expression of genes associated with cytokine production, and genes implicated in regulating bone metabolism, in bone stromal and osteoblast cells incubated under standard ground conditions and under conditions of neutral buoyancy, and in the presence/absence of serum from normal or sleep-deprived mice. We observed a clear interaction between these two conditions (exposure to neutral buoyancy and serum stimulation) in promoting enhanced osteoclastogenesis. Both conditions independently altered expression of a number of cytokines implicated in the regulation of bone metabolism. However, using stromal cells from IL-1 and TNFx cytokine(r) KO mice, we concluded that the increased bone loss under microgravity conditions was not primarily cytokine mediated.     

Generating requirements for complex embedded systems using State Analysis

It has become clear that spacecraft system complexity is reaching a threshold where customary methods of control are no longer affordable or sufficiently reliable. At the heart of this problem are the conventional approaches to systems and software engineering based on subsystem-level functional decomposition, which fail to scale in the tangled web of interactions typically encountered in complex spacecraft designs. Furthermore, there is a fundamental gap between the requirements on software specified by systems engineers and the implementation of these requirements by software engineers. Software engineers must perform the translation of requirements into software code, hoping to accurately capture the systems engineer's understanding of the system behavior, which is not always explicitly specified. This gap opens up the possibility for misinterpretation of the systems engineer's intent, potentially leading to software errors. This problem is addressed by a systems engineering methodology called State Analysis, which provides a process for capturing system and software requirements in the form of explicit models. This paper describes how requirements for complex aerospace systems can be developed using State Analysis, using representative spacecraft examples.     

With a grain of salt: what halite has to offer to discussions on the origin of life

This experimental study investigated how the dynamics of the crystallization of the evaporite mineral halite could affect the accumulation and preservation of organic macromolecules present in the crystallizing solution. Halite was grown under controlled conditions in the presence of polymer nanoparticles that acted as an analog to protocellular material. Optical microscopy, atomic force microscopy, and laser scanning confocal fluorescence microscopy were used to trace the localization of the nanoparticles during and after growth of halite crystals. The present study revealed that the organic nanoparticles were not regularly incorporated within the halite, but were very concentrated on its surfaces. Their distribution was controlled dominantly by the morphologic surface features of the mineral rather than by specific molecular interactions with an atomic plane of the mineral. This means that the distribution of organic molecules was controlled by surfaces like those of halite's evaporitic growth forms. The experiments with halite also demonstrated that a mineral need not continuously incorporate organic molecules during its crystallization to preserve those molecules: After rejection by (non-incorporation into) the crystallizing halite, the organic nanoparticles increased in concentration in the evaporating brine. They ultimately either adsorbed in rectilinear patterns onto the hopper-enhanced surfaces and along discontinuities within the crystals, or they were encapsulated within fluid inclusions. Of additional importance in origin-of-life considerations is the fact that halite in the natural environment rapidly can change its role from that of a protective repository (in the absence of water) to that of a source of organic particles (as soon as water is present) when the mineral dissolves.     

华东地区围护结构节能研究

根据南京市的典型年逐时气象参数，对于该市的某一座高层建筑物，应用自编的逐时动态负荷模拟程序，输入围护结构（窗户、墙体和屋顶）相关的物理参数及其与周围环境的关系（地点及朝向等），计算围护结构冬季采暖期散热量及夏季制冷得热量。结果表明，采用双层塑窗代替单层塑窗，使用节能墙体代替传统墙体能够使得冬季围护结构传散热量减少51％，夏季围护结构总得热量减少46％。因此，这一结果为华东地区建筑节能技术提供了理论依据。     

无穷观问题的研究(Ⅲ)——‘每一''与‘所有''

本组系列论文（I）－（Ⅴ）从数学和认识论的角度系统地研究了无穷观问题的历史发展和现状，确立了无穷观背景世界的三分法原则，指出了两种穷观相互排斥的局限性，形成了统一两种无穷于同一框架中的基本观点，并建立了一个统一实无限与潜无限于同一框架中的公理集合论系统APAS。     

金属载体上线天线阻抗与辐射特性的矩量法研究

用线网格模拟金属载体表面，应用矩量法求出天线及载体网格上的电流分布，据此研究在该金属载体影响下的天线特性，在计算阻抗矩阵元素时，利用了非对称正弦偶极子辐射场的精确表达式，并采用了直接复数积分，简化了计算公式，本文给出了几种金属载体上线天线的阻抗与辐射特性的计算结果，它们与有关文献上的数据或实验结果一致，最后计算了一种舰船简单模型上两根线天线的远区辐射场及它们的自阻抗与互阻抗。     

飞机穿越微下击暴流风切变的智能控制

在应用模糊逻辑建模与辨识方法建立微下击暴流风切变模型的基础上，根据恒定俯仰姿态改出微下击暴流的飞行引导策略，提出了一种改出微下击暴流风切变的模糊反馈控制系统，并将遗传算法应用于该模糊逻辑控制器的设计。结果表明，本文提出的建模方法能够更真实地反映出飞机穿越微下击暴流风场的动态特性；采用模糊逻辑控制器，可使得飞机在穿越微下击暴流风场时具有较好的改出性能；另外，遗传算法的应用对已设计的模糊逻辑控制器进行了优化，进一步改善了飞机穿越微下击暴流的性能。     

基于批生产的逐段式车间作业调度算法

探讨了离散作业型（Job shop）车间中的作业调度的分阶段模型，并根据离散作业调度的阶段性提出了基于作业状态空间的逐段式车间作业调度算法，通过对一个实际车间作业调度仿真比较，此算法运算速度比最短加工时间（SPT）和最少工作量剩余（LWR）算法快，其调度结果在实际作业车间具有可执行性。