French research program on the physiological problems caused by weightlessness. Use of the primate model

The need to acquire a better knowledge of the main biological problems induced by microgravity implies--in addition to human experimentation--the use of animal models, and primates seem to be particularly well adapted to this type of research. The major areas of investigation to be considered are the phospho-calcium metabolism and the metabolism of supporting tissues, the hydroelectrolytic metabolism, the cardiovascular function, awakeness, sleep-awakeness cycles, the physiology of equilibrium and the pathophysiology of space sickness. Considering this program, the Centre d'Etudes et de Recherches de Medecine Aerospatiale, under the sponsorship of the Centre National d'Etudes Spatiales, developed both a program of research on restrained primates for the French-U.S. space cooperation (Spacelab program) and for the French-Soviet space cooperation (Bio-cosmos program), and simulation of the effects of microgravity by head-down bedrest. Its major characteristics are discussed in the study.     

Weightlessness: a case history

The facts presented represent, for convenience, a composite clinical picture of the three crewmen aboard Skylab II as observed by me.     

Prolonged weightlessness and calcium loss in man

Data have been accumulated from a series of studies in which men have been subjected to weightlessness in orbital space flight for periods of up to 12 weeks. These data are used to predict the long term consequences of weightlessness upon the skeletal system. Space flight induced a loss of calcium which accelerated exponentially from about 50 mg/d at the end of 1 week to approx. 300 mg/d at the end of 12 weeks. The hypercalciuria reached a constant level within 4 weeks while fecal calcium losses continued to increase throughout the period of exposure. This apparent diminution of gastrointestinal absorptive efficiency was accompanied by a slight decline in the plasma level of parathyroid hormone and a slight elevation in the plasma level of calcium and phosphorus. Although losses in mineral from the calcaneus were closely correlated with the calcium imbalance, no changes were detected in the mineral mass of the ulna and radius. From the data presented it is concluded that the process of demineralization observed in space flight is more severe than would be predicted on the basis of observations in immobilized, bed rested, or paralyzed subjects. It is, moreover, suggested that the process may not be totally reversible.     

Radar Doppler Spectra of Turbulent Ionized Wakes

The evaluation of the double convolution integrat involved in the expression of the radar response to scattering from a turbulent ionized wake is simplified by the approximation technique presented here, so that the Doppler spectrum parameters can be explicitly expressed in terms of the wake characteristics.     

Postmission plasma volume and red-cell mass changes in the crews of the first two Skylab missions

Red-cell mass determinations were performed before and after the first two Skylab missions. The data showed a 14% mean decrease in red-cell mass after the 28-day mission and a 12% mean decrease after the 59-day mission. The red-cell mass returned to premission levels more slowly after the shorter (28-day) than after the longer mission. Plasma volume decreases were found after each mission. with the crew from the longer mission showing the greater change (13% vs. 8.4%). Postmission decreases in red-cell mass and plasma volume have been a general finding in crewmen who return from short or long spaceflight.     

Cross Polarization in Radomes: A Program for Its Computation

A study is made of transmission by radomes, with particular reference to cross polarization, and of the consequent radiation patterns of the radome with its aerial for both linear and circular polarizations. The work is embodied in a computer program which considers a scanner of specifiable size, position, and power distribution at different orientations inside a multilayer radome of given dimensions, class of shape, and construction in terms of the number and properties of its layers. Initially, rays are traced from points on the scanner, and details of their paths and propagation are presented in tables of preliminary results; later, diffraction theory is used. Polar diagrams of cross polarization, of main beam, etc., are presented in final tables for the system. Nearly all the parameters are specifiable, and so the program has reasonably general applicability, and it can also assess the effects of bandwidth, tapering of layer thickness, complex permittivity, and other parameters of the system.     

Attitude Determination Via Nonlinear Filtering

The theory of nonlinear filtering has been applied to the problem of the attitude determination of a satellite. Two approximation methods have been studied with a view to practical implementation. Computer simulation results are included.     

An Electrooptical Automatic Gain Control

The laser beam affords a valuable carrier medium for an optical calmunication system, but such a system for transmission through the atmosphere is subjected to wide fluctuations in received signal strength because of turbulence. An electrooptical automatic gain control system em has been studied and built which can substantially reduce the effect of these fluctuations. The effect of system parameters on the control characteristics are considered.     

A Comparison of Expected Flight Times for Intercept and Pure Pursuit Missiles

The relative merits of intercept and pure pursuit homing are investigated by comparing the expected flight times to a nonmaneuvering target. The analysis is performed for the initial target heading angle uniformly distributed with arbitrary mean and variance. Two specific examples illustrate that intercept homing holds little statistical advantage over pure pursuit homing except when the speed advantage of the missile is very small.