Subatmospheric decompression: neurological and behavioural studies

Several studies in animals over the past decade have shown that prolonged exposures to pressures within the range 226 mm Hg to 160 mm Hg (30,000 to 37,500 ft) are likely to lead to brain damage. This often results in neurological and behavioural disturbance, which may be subtle and reversible or gross and ultimately fatal. The appearance of these impairments is often delayed until several hours or even days after exposure. Immediate survival does not necessarily ensure recovery. In contrast, decompression to pressures below 160 mm Hg or above 226 mm Hg are unlikely to have adverse effects if the exposure is survived. The most probable outcomes of such decompressions are death or uneventful recovery.     

Biomedical problems of EVA support during manned space flight to Mars

Current projects of manned missions to Mars are aimed to their realization in the second-third decades of this century. The purpose of this paper is to determine and review the main biomedical problems, that require a first and foremost decision for safety support of extravehicular activity (EVA) carried out by crewmembers of the Mars expedition. To a number of such problems the authors of the paper attribute a creation of adequate EVA equipment intended, first, for assembly of interplanetary spacecraft on the Earth orbit, performance of maintenance operations and scientific researches on the external surface of spacecraft during interplanetary flight and, secondly, for work on the Mars surface. New generation of space suits with low weight, high mobility and acceptable risk of decompression sickness must be as a central component of EVA equipment. The program for preparation to a Mars expedition also has to include special investigations in order to design the means and methods for a reliable protection of crew against space radiation, to elaborate the approach to medical monitoring and primary medical care during autonomous space mission, to maintain good health condition of crewmembers during EVA under the Mars gravity (0.38 g) after super long-term flight in weightlessness.     

Solution of the Problem of Optimal Spacecraft Launching into Orbit Using Reactive Acceleration and Solar Sail in Kustaanheimo–Stiefel Variables

Cosmic Research - Using the Pontryagin maximum principle and the Kustaanheimo–Stiefel variables, the spatial problem of optimal launching into a given orbit of a spacecraft (SC) controlled by...     

Space–Time Structure of Energetic Electron Precipitations according to the Data of Balloon Observations and Polar Satellite Measurements on February 1–6, 2015

Cosmic Research - The results of an analysis of the space–time characteristics and dynamics of precipitations of magnetospheric electrons with energies in the range from 0.1 to 0.7 MeV are...     

Designing corrections for the trajectory of the <Emphasis Type="Italic">Spektr-R</Emphasis> spacecraft in the event of immersions into the Moon’s sphere of influence

The results of updating the parameters of motion of the Spektr-R spacecraft at the end of 2016 have shown that, in January 2018, with a probability close to unity, the condition that a spacecraft stay in the Earth’s shadow is violated; however, in May of the same year, the ballistic life of the spacecraft will be terminated. Thus, in 2017, the question arose of how to design the correction of flight of this spacecraft using its onboard propulsion system. The correction was designed with allowance for the fact that, for the first time since it was launched, the spacecraft in the course of several years, beginning with 2017, repeatedly approaches the Moon, deeply immersing into its sphere of influence. This paper presents the technologically and organizationally convenient, allowable versions of upcoming correction of the Spektr-R spacecraft trajectory and justifies the particular scheme of its implementation.     

Preliminary calibration results of VEGA 1 and 2 SIGMA-3 gas chromatograph

SIGMA - 3 gas chromatograph on board VEGA 1 and 2 landing probes has been operated successfully in the 60 - 50 km altitude range, providing several in - situ chemical analysis of the gas and the aerosols of Venus cloud layers. Post flight calibration required to derive atmospheric abundancies from gas chromatograms were carried out using the SIGMA - 3 spare model. A Venus atmospheric aerosol simulation chamber was used in which sulfuric acid droplets were generated. Preliminary results of these calibration experiments indicate that the concentration of sulfuric acid in the upper part of the clouds ( 60 to 55 km) is about 1 mg/m³ and suggest that an additional constituant must be present in noticeable amount in the aerosols. From these experiments the mixing ratio upper limits of SO₂ is 100 ppmV and of H₂S and COS is few 10 ppmV.     

The Extreme Ultraviolet Imager Investigation for the IMAGE Mission

The Extreme Ultraviolet Imager (EUV) of the IMAGE Mission will study the distribution of He⁺ in Earth's plasmasphere by detecting its resonantly-scattered emission at 30.4 nm. It will record the structure and dynamics of the cold plasma in Earth's plasmasphere on a global scale. The 30.4-nm feature is relatively easy to measure because it is the brightest ion emission from the plasmasphere, it is spectrally isolated, and the background at that wavelength is negligible. Measurements are easy to interpret because the plasmaspheric He⁺ emission is optically thin, so its brightness is directly proportional to the He⁺ column abundance. Effective imaging of the plasmaspheric He⁺ requires global `snapshots in which the high apogee and the wide field of view of EUV provide in a single exposure a map of the entire plasmasphere. EUV consists of three identical sensor heads, each having a field of view 30° in diameter. These sensors are tilted relative to one another to cover a fan-shaped field of 84°×30°, which is swept across the plasmasphere by the spin of the satellite. EUVs spatial resolution is 0.6° or 0.1 R _E in the equatorial plane seen from apogee. The sensitivity is 1.9 count s^–1 Rayleigh^–1, sufficient to map the position of the plasmapause with a time resolution of 10 min.     

Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation.

Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process.     

The Role and Contributions of Energetic Neutral Atom (ENA) Imaging in Magnetospheric Substorm Research

Energetic Neutral Atom (ENA) imaging has contributed substantially to substorm research. This technique has allowed significant advances in areas such as observation and quantification of injected particle drift as a function of energy, observation of dynamics in the tail that are directly related to the effects of imposed (growth phase) and induced (expansion phase) electric fields on the plasma, the prompt extraction of oxygen from the ionosphere during substorms, the relationship between storms and substorms, and the timing of substorm ENA signatures. We present discussion of the advantages and shortcomings of the ENA technique for studying space plasmas. Although the technique is in its infancy, it is yielding results that enrich our understanding of the substorm process and its effects.