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641.
In this paper we discuss the effect of microgravity on T cells and we present the data of studies with two new machines for 0 g simulations. Several experiments in space show that mitogenic T cell activation is lost at 0 g. Immunocytochemistry indicates that such effect is associated with changes of the cytoskeleton. Biochemical studies suggest that the lack of expression of the interleukin-2 receptor is one of the major causes of the loss of activity. In fact, interleukin-2 is the third signal required for full activation. In order to deepen our investigations we are now working with the free-fall machine, FFM, invented by D. Mesland, and with the random positioning machine, RPM, or three-dimensional clinostat, developed by T. Hoson. The FFM produces periods of free-fall lasting approximately 800 ms followed by bounces of 15-30 g lasting 45-60 ms. The RPM eliminates the effect of gravity by rotating biological specimen randomly around two orthogonal axes. While the FFM failed to reproduce the results obtained with T lymphocytes in space, the data from the RPM are in good agreement with those in real microgravity. In fact, the inhibition of the mitotic index in the RPM is 89% compared to static controls. The RPM (as the FFM) can carry markedly larger specimen than the fast rotating clinostat and thus allows to conduct comprehensive studies to select suitable biological objects for further investigations in space.  相似文献   
642.
Protein crystals, grown under reduced gravity conditions, are either superior or inferior in their structural perfection than their Earth-grown counterparts. A reduction of the crystals' quality due to low-gravity effects on the growth processes cannot be understood from existing models. In this paper we put forth a rationale which predicts either advantages or disadvantages of microgravity growth. This rationale is based on the changes in the effective solute and impurity supply rates in microgravity and their effects on the intrinsic growth rate fluctuations that arise from the coupling of bulk transport to nonlinear interfacial kinetics and cause severe inhomogeneities. Depending on the specific diffusivity and kinetic coefficient of a protein and the impurities in the solution, either transport enhancement through forced flow or transport suppression under reduced gravity can result in a reduction of the kinetic fluctuations and, thus, growth with higher structural perfection. Investigating this mechanism of microgravity effects, we first demonstrate a one-to-one correspondence between these fluctuations, that are due to the bunching of growth steps, and the formation of defects in the crystals. We have confirmed the forced flow aspects of this rationale in ground-based experiments with lysozyme utilizing flowing solutions with varying, well characterized impurity contents.  相似文献   
643.
644.
We investigate the behavior of mean values of the solar wind’s and interplanetary magnetic field’s (IMF) parameters and their absolute and relative variations during the magnetic storms generated by various types of the solar wind. In this paper, which is a continuation of paper [1], we, on the basis of the OMNI data archive for the period of 1976–2000, have analyzed 798 geomagnetic storms with D st ≤ −50 nT and their interplanetary sources: corotating interaction regions CIR, compression regions Sheath before the interplanetary CMEs; magnetic clouds MC; “Pistons” Ejecta, and an uncertain type of a source. For the analysis the double superposed epoch analysis method was used, in which the instants of the magnetic storm onset and the minimum of the D st index were taken as reference times. It is shown that the set of interplanetary sources of magnetic storms can be sub-divided into two basic groups according to their slowly and fast varying characteristics: (1) ICME (MC and Ejecta) and (2) CIR and Sheath. The mean values, the absolute and relative variations in MC and Ejecta for all parameters appeared to be either mean or lower than the mean value (the mean values of the electric field E y and of the B z component of IMF are higher in absolute value), while in CIR and Sheath they are higher than the mean value. High values of the relative density variation sN/〈N〉 are observed in MC. At the same time, the high values for relative variations of the velocity, B z component, and IMF magnitude are observed in Sheath and CIR. No noticeable distinctions in the relationships between considered parameters for moderate and strong magnetic storms were observed.  相似文献   
645.
A concept for a new space-based cosmology mission called the Dark Ages Radio Explorer (DARE) is presented in this paper. DARE’s science objectives include: (1) When did the first stars form? (2) When did the first accreting black holes form? (3) When did Reionization begin? (4) What surprises does the end of the Dark Ages hold (e.g., Dark Matter decay)? DARE will use the highly-redshifted hyperfine 21-cm transition from neutral hydrogen to track the formation of the first luminous objects by their impact on the intergalactic medium during the end of the Dark Ages and during Cosmic Dawn (redshifts z = 11–35). It will measure the sky-averaged spin temperature of neutral hydrogen at the unexplored epoch 80–420 million years after the Big Bang, providing the first evidence of the earliest stars and galaxies to illuminate the cosmos and testing our models of galaxy formation. DARE’s approach is to measure the expected spectral features in the sky-averaged, redshifted 21-cm signal over a radio bandpass of 40–120 MHz. DARE orbits the Moon for a mission lifetime of 3 years and takes data above the lunar farside, the only location in the inner solar system proven to be free of human-generated radio frequency interference and any significant ionosphere. The science instrument is composed of a low frequency radiometer, including electrically-short, tapered, bi-conical dipole antennas, a receiver, and a digital spectrometer. The smooth frequency response of the antennas and the differential spectral calibration approach using a Markov Chain Monte Carlo technique will be applied to detect the weak cosmic 21-cm signal in the presence of the intense solar system and Galactic foreground emissions.  相似文献   
646.
Inflatable/deployable structures are under consideration as habitats for future Lunar surface science operations. The use of non-traditional structural materials combined with the need to maintain a safe working environment for extended periods in a harsh environment has led to the consideration of an integrated structural health management system for future habitats, to ensure their integrity. This article describes recent efforts to develop prototype sensing technologies and new self-healing materials that address the unique requirements of habitats comprised mainly of soft goods. A new approach to detecting impact damage is discussed, using addressable flexible capacitive sensing elements and thin film electronics in a matrixed array. Also, the use of passive wireless sensor tags for distributed sensing is discussed, wherein the need for on-board power through batteries or hardwired interconnects is eliminated. Finally, the development of a novel, microencapuslated self-healing elastomer with applications for inflatable/deployable habitats is reviewed.  相似文献   
647.
The advantages of a constant volume combustion cycle as compared to constant pressure combustion in terms of thermodynamic efficiency has focused the search for advanced propulsion on detonation engines. Detonation of acetylene mixed with oxygen in various proportions is studied using mathematical modeling. Simplified kinetics of acetylene burning includes 11 reactions with 9 components. Deflagration to detonation transition (DDT) is obtained in a cylindrical tube with a section of obstacles modeling a Shchelkin spiral; the DDT takes place in this section for a wide range of initial mixture compositions. A modified ka-omega turbulence model is used to simulate flame acceleration in the Shchelkin spiral section of the system. The results of numerical simulations were compared with experiments, which had been performed in the same size detonation chamber and turbulent spiral ring section, and with theoretical data on the Chapman–Jouguet detonation parameters.  相似文献   
648.
This paper considers the design of PCM signals with system constraints using Pontryagin's maximum principle. The transmitter signal as well as the correlation signal are determined while maximizing the output signal-to-noise ratio. Both the single and three-pole transmitter filters are considered. An upper bound has been obtained on the performance of PCM signals with constraints.  相似文献   
649.
Formation and motion (at the initial stage) of six limb CMEs detected in the period June 2010 to June 2011 are investigated using the high-resolution data of the PROBA2 and SDO spacecraft combined with the data of SOHO/LASCO coronagraphs. It is demonstrated that several loop-like structures of enhanced brightness originate in the region of CME formation, and they move one after another with, as a rule, different velocities. These loop-like structures in the final analysis form the frontal structure of CME. Time dependences of the velocity and acceleration of the ejection’s front are obtained for all CMEs under consideration. A conclusion is drawn about possible existence of two classes of CMEs depending on their velocity time profiles. Ejections, whose velocity after reaching its maximum sharply drops by a value of more than 100 km/s and then goes over into a regime of slow change, belong to the first class. Another class of CMEs is formed by ejections whose velocity changes slowly immediately after reaching the maximum. It is demonstrated that the CME’s angular dimension increases at the initial stage of ejection motion up to a factor of 3 with a time scale of doubling the angular size value within the limits 3.5–11 min since the moment of the first measurement of this parameter of an ejection. For three CMEs it is shown that at the initial stage of their motion for a certain time interval they are stronger expanded than grow in the longitude direction.  相似文献   
650.
The RF SRC—Institute of Biomedical Problems, Russian Academy of Sciences, developed Biorisk hardware to study the effects of long-term exposure of dormant forms of various organisms to outer space and used it to complete a series of experiments on the Russian Module (RM) of the International Space Station (ISS).The experiments were performed using prokaryotes (Bacillus bacteria) and eukaryotes (Penicillium, Aspergillus, and Cladosporium fungi), as well as spores, dormant forms of higher plants, insects, lower crustaceans, and vertebrates. The biological samples were housed in two containers that were exposed to outer space for 13 or 18 months. The results of the 18-month experiment showed that, in spite of harsher temperature than in the first study, most specimens remained viable.These experiments provided evidence that not only bacterial and fungal spores but also dormant forms of organisms that reached higher levels of evolutionary development had the capability to survive a long-term exposure to outer space. This observation suggests that they can be transferred on outer walls of space platforms during interplanetary missions.  相似文献   
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