Effects of microgravity on c-fos gene expression in osteoblast-like MC3T3-E1 cells.

The paper summarizes the data on proliferation and gravity-related gene expression of osteoblasts that were obtained from an experiment conducted under simulated and real microgravity conditions. Simulated microgravity conditions obtained in a clinostat depress proliferation of both osteoblast-like MC3T3-E1 and HeLa carcinoma cells. This depression of proliferation occurs in a collagen gel culture in which the flow of culture medium by rotation may be reduced. Interestingly, MC3T3-E1 cells which are probably one of target cells to microgravity are more sensitive than the HeLa cells. Simulated microgravity inhibited the epidermal growth factor (EGF)-induced c-fos gene expression in the MC3T3-El cells. To examine in detail the effect of real microgravity on the EGF signal transduction cascade in osteoblasts, MC3T3-E1 cells were cultured in the Cell Culture Experiment Module of the sounding rocket TR-1A6. The EGF-induced c-fos expression in cells was depressed under short-term microgravity conditions in the sounding rocket, while the phosphorylation of mitogen-activated protein kinase (MAPK) was not affected compared with the controls grown on the ground. These results suggest that an action site of microgravity in the signal transduction pathway may be downstream of MAPK.     

Beagle 2: a proposed exobiology lander for ESA's 2003 Mars Express mission.

The aim of the proposed Beagle 2 small lander for ESA's 2003 Mars Express mission is to search for organic material on and below the surface of Mars and to study the inorganic chemistry and mineralogy of the landing site. The lander will have a total mass of 60kg including entry, descent, and landing system. Experiments will be deployed on the surface using a robotic arm. It will use a mechanical mole and grinder to obtain samples from below the surface, under rocks, and inside rocks. Sample analysis by a mass spectrometer will include isotopic analysis. An optical microscope, an X-ray spectrometer and a Mossbauer spectrometer will conduct in-situ rock studies.     

Improvement of forebody/inlet integration for hypersonic vehicle

Results of a numerical (CFD) study of the influence of the forebody shape on local flow parameters at a bottom-mounted inlet entrance are presented. The free-stream Mach number is assumed to be 3.5–7.0. Some recommendations on forebody shape optimization are provided. Main characteristics of the air inlet are evaluated.     

Study of physiological effects of weightlessness and artificial gravity in the flight of the biosatellite Cosmos-936.

In the 18.5-day flight of the Soviet biosatellite Cosmos-936 (3-22, August 1977) com-parative investigations of the physiological effects of prolonged weightlessness (20 rats) and artificial gravity of 1 g (10 rats) were carried out. Throughout the flight artificial gravity was generated by means of animal rotation in two centrifuges with a radius of 320mm. Postflight examination of animals and treatment of the flight data were performed by Soviet scientists in collaboration with the specialists from Bulgaria, Czechoslovakia, the German Democratic Republic, Hungary, Poland, Rumania, France and the U.S.A. During the flight the total motor activity of the weightless rats was higher and their body temperature was lower than those of the centrifuged animals. Postflight examination of the weightless rats showed a greater percentage of errors during maze an increase in water intake and a decrease in diuresis; a fall of the resistance of peripheral red cells; an increase in the conditionally pathogenic microflora in the mouth; a decrease of oxygen consumption, carbon dioxide production and energy expenditures; a drop in the static physical endurance; a decline in the capacity to keep balance on the rail; an increase in the latent period of the lifting reflex, etc. The centrifugal animals displayed lesser or no change of the above type. These findings together with the biochemical and morphological data give evidence that during and after flight adaptive processes in the centrifuged rats developed better.     

Magnetic Field Fluctuations in the Solar Wind, Foreshock and Magnetosheath： Cluster Data Analysis

46 magnetosheath crossing events from the two years (2001.2-2003.1) of Cluster magnetic field measurements are identified and used to investigate the characters of the magnetic field fluctuations in the regions of undisturbed solar wind, foreshock, magnetosheath. The preliminary results indicate the properties of the plasma turbulence in the magnetosheath are strongly controlled by IMF orientation with respect to the bow shock normal. The amplitude of the magnetic field magnitude and direction variations behind quasi-parallel bow shock are larger than those behind quasi-perpendicular bow shock. Almost purely compressional waves are found in quasi-perpendicular magnetosheath.     

A method of technologic audit of technical re-equipment projects in aircraft production enterprises

A method of technologic audit for technical re-equipment of enterprises is considered. The method developed is intended to verify technological solutions of projects of technical re-equipment of enterprises according to indicators of productivity.     

Kink mode m = 1 in magnetic tube with discontinuous magnetic field

In this paper, we study conditions of realization and stability of kink modes with azimuthal wave numbers $m=\pm 1$ in cylindrical plasma flex with twisted magnetic field and homogeneous current along its axis. We assume permanent axial magnetic field both inside and outside the flex, surrounded by currentless plasma. Azimuthal magnetic field decreases inversely proportional to the distance from the boundary beyond the flex. We derived dispersion equations for stable and unstable modes in approximation of “thin” plasma flex. The analysis of equations has been provided for the case of discontinuous axial magnetic field on flex’s boundary. Conditions of propagation of wave modes have been defined. It was shown, that unstable modes can be implemented in certain interval of longitudinal wavenumbers. Results can be applied for the interpretation of solar magnetic tubes behavior, using measurements, provided by spacecrafts.     

Polyhedron tracking and gravity tractor asteroid deflection

In the wake of the Chelyabinsk airburst, the defense against hazardous asteroids is becoming a topic of high interest. This work improves the gravity tractor asteroid deflection approach by tracking realistic small body shapes with tilted ion engines. An algorithm for polyhedron tracking was evaluated in a fictitious impact scenario. The simulations suggest a capability increase up to 38.2% with such improved tilting strategies. The long- and short-term effects within polyhedron tracking are illustrated. In particular, the orbital reorientation effect is influential when realistic asteroid shapes and rotations are accounted for. Also analyzed is the subject of altitude profiles, a way to tailor the gravity tractor performance, and to achieve a steering ability within the B-plane. A novel analytical solution for the classic gravity tractor is derived. It removes the simulation need for classic tractor designs to obtain comparable two body model Δv$\mathrm{\Delta }v$ figures. This paper corroborates that the asteroid shape can be exploited for maximum performance. Even a single engine tilt adjustment at the beginning of deflection operations yields more deflection than a fixed preset tilt.     

Applications of tuned mass dampers to improve performance of large space mirrors

In order for future imaging spacecraft to meet higher resolution imaging capability, it will be necessary to build large space telescopes with primary mirror diameters that range from 10 m to 20 m and do so with nanometer surface accuracy. Due to launch vehicle mass and volume constraints, these mirrors have to be deployable and lightweight, such as segmented mirrors using active optics to correct mirror surfaces with closed loop control. As a part of this work, system identification tests revealed that dynamic disturbances inherent in a laboratory environment are significant enough to degrade the optical performance of the telescope. Research was performed at the Naval Postgraduate School to identify the vibration modes most affecting the optical performance and evaluate different techniques to increase damping of those modes. Based on this work, tuned mass dampers (TMDs) were selected because of their simplicity in implementation and effectiveness in targeting specific modes. The selected damping mechanism was an eddy current damper where the damping and frequency of the damper could be easily changed. System identification of segments was performed to derive TMD specifications. Several configurations of the damper were evaluated, including the number and placement of TMDs, damping constant, and targeted structural modes. The final configuration consisted of two dampers located at the edge of each segment and resulted in 80% reduction in vibrations. The WFE for the system without dampers was 1.5 waves, with one TMD the WFE was 0.9 waves, and with two TMDs the WFE was 0.25 waves. This paper provides details of some of the work done in this area and includes theoretical predictions for optimum damping which were experimentally verified on a large aperture segmented system.     

The construction of gravitational field models on the basis of satellite measurements of gravitational potential derivatives

In [1] expressions were constructed for the derivatives of all the orders of a planet’s gravitational potential with respect to the rectangular coordinates related to the gravity center of a planet. These expressions are series of spherical functions. The coefficients of the series of first-order derivatives depend on two Stokes constants, whereas the coefficients of next-order derivatives are linear combinations of the coefficients of preceding-order derivatives. In the present paper the derived expressions for the first and second potential derivatives are transformed into the form that is most convenient for solving the inverse problem, i.e., evaluating Stokes constants from satellite measurements of these derivatives. Each term of the new series for a derivative depends on a sum of two Stokes constants multiplied by linear combinations of several spherical functions. The new form of the expansions for the potential derivatives makes it possible to calculate Stokes constants by simultaneously applying satellite data either for all three first-order potential derivatives, or for all six second-order derivatives. The constructed series may be applied for modeling the Earth’s gravitational field from the satellite data obtained in the international CHAMP, GRACE, and GOCE missions.