Neoplastic cell transformation by high-LET radiation: molecular mechanisms.

Experimental data on molecular mechanisms are essential for understanding the bioeffects of radiation and for developing biophysical models, which can help in determining the shape of dose-response curves at very low doses, e.g., doses less than 1 cGy. Although it has been shown that ionizing radiation can cause neoplastic cell transformation directly, that high-LET heavy ions in general can be more effective than photons in transforming cells, and that the radiogenic cell transformation is a multi-step process [correction of processes], we know very little about the molecular nature of lesions important for cell transformation, the relationship between lethal and transformational damages, and the evolution of initial damages into final chromosomal aberrations which alter the growth control of cells. Using cultured mouse embryo cells (C3H10T1/2) as a model system, we have collected quantitative data on dose-response curves for heavy ions with various charges and energies. An analysis of these quantitative data suggested that two DNA breaks formed within 80 angstroms may cause cell transformation and that two DNA breaks formed within 20 angstroms may be lethal. Through studies with restriction enzymes which produce DNA damages at specific sites, we have found that DNA double strand breaks, including both blunt- and cohesive-ended breaks, can cause cell transformation in vitro. These results indicate that DNA double strand breaks can be important primary lesions for radiogenic cell transformation and that blunt-ended double strand breaks can form lethal as well as transformational damages due to misrepair or incomplete repair in the cell. The RBE-LET relationship is similar for HGPRT gene mutation, chromosomal deletion, and cell transformation, suggesting common lesions may be involved in these radiation effects. The high RBE of high-LET radiation for cell killing and neoplastic cell transformation is most likely related to its effectiveness in producing DNA double strand breaks in mammalian cells. At present the role of oncogenes in radiation cell transformation is unclear.     

Determination of optimal samples for robot calibration based on error similarity

Industrial robots are used for automatic drilling and riveting.The absolute position accuracy of an industrial robot is one of the key performance indexes in aircraft assembly,and can be improved through error compensation to meet aircraft assembly requirements.The achievable accuracy and the difficulty of accuracy compensation implementation are closely related to the choice of sampling points.Therefore,based on the error similarity error compensation method,a method for choosing sampling points on a uniform grid is proposed.A simulation is conducted to analyze the influence of the sample point locations on error compensation.In addition,the grid steps of the sampling points are optimized using a statistical analysis method.The method is used to generate grids and optimize the grid steps of a Kuka KR-210 robot.The experimental results show that the method for planning sampling data can be used to effectively optimize the sampling grid.After error compensation,the position accuracy of the robot meets the position accuracy requirements.     

Integrated Safety Culture Model and Application

A new safety culture model is constructed and is applied to analyze the correlations between safety culture and SMS. On the basis of previous typical definitions, models and theories of safety culture, an in-depth analysis on safety culture＇s structure, composing elements and their correlations was conducted. A new definition of safety culture was proposed from the perspective of sub-culture. 7 types of safety sub-culture, which are safety priority culture, standardizing culture, flexible culture, learning culture, teamwork culture, reporting culture and justice culture were defined later. Then integrated safety culture model （ISCM） was put forward based on the definition. The model divided safety culture into intrinsic latency level and extrinsic indication level and explained the potential relationship between safety sub-culture and all safety culture dimensions. Finally in the analyzing of safety culture and SMS, it concluded that positive safety culture is the basis of im plementing SMS effectively and an advanced SMS will improve safety culture from all around.     

Heavy-ion induced genetic changes and evolution processes.

On Moon and Mars, there will be more galactic cosmic rays and higher radiation doses than on earth. Our experimental studies showed that heavy ion radiation can effectively cause mutation and chromosome aberrations and that high-LET heavy-ion induced mutants can be irreversible. Chromosome translocations and deletions are common in cells irradiated by heavy particles, and ionizing radiations are effective in causing hyperploidy. The importance of the genetic changes in the evolution of life is an interesting question. Through evolution, there is an increase of DNA content in cells from lower forms of life to higher organisms. The DNA content, however, reached a plateau in vertebrates. By increasing DNA content, there can be an increase of information in the cell. For a given DNA content, the quality of information can be changed by rearranging the DNA. Because radiation can cause hyperploidy, an increase of DNA content in cells, and can induce DNA rearrangement, it is likely that the evolution of life on Mars will be effected by its radiation environment. A simple analysis shows that the radiation level on Mars may cause a mutation frequency comparable to that of the spontaneous mutation rate on Earth. To the extent that mutation plays a role in adaptation, radiation alone on Mars may thus provide sufficient mutation for the evolution of life.     

PWM full-bridge converter with natural input power factor correction

A pulsewidth modulated (PWM) full-bridge converter that simultaneously performs input power factor correction (PFC) and DC-DC conversion is proposed. The converter is the same as the standard voltage-fed PWM full-bridge converter with a diode-bridge low-pass filter front end, but with a slight modification that results in an improvement in power factor that is sufficient to satisfy the EN61000-3-2 requirements for electrical equipment. The operation of the converter is explained and analyzed, and the results of the analysis are used to determine the converter's steady-state characteristics, which are discussed in detail. A design procedure for the selection of components is then derived and demonstrated with an example. The feasibility of the converter and its ability to satisfy EN61000-3-2 requirements on electrical equipment is shown with results obtained from an experimental prototype.     

高校图书馆向社会服务的探索

本文就高校图书馆在市场经济体制下向社会服务的重要性、可能性、服务的途径和方式进行了探讨。     

Instrumentenentwicklungen für anwendungsaufgaben der fernerkundung photogrammetrie,geophysik und geodäsie

(Instrument Developments for Applications in Remote Sensing, Photogrammetry, Geophysics and Geodesy) The Modular Optoelectronic Multispectral Seanner MOMS-01, a CCD camera using the push-broom scanner principle, is presented in this paper in its flight configuration. This instrument will be the first European-built spaceborne unaging system for remote sensing applications (launch with Shuttle flight No. 7).Follow-on developments of this initial two-channel version are oriented to an extension of capabilities by a panchromatic high-resolution stereoscopic module for thematic mapping and two additional spectral channels in the reflective IR (up to 2.3 μm) offering a high interpretation potential for future earth resources exploration missions. Furthermore the subjects of advanced laser technology studies are introduced: A picosecond pulse laser system for detection of tectonic motions and for geodetic application, a CO laser for ultra precise range rate determination (Earth potential and Geoid) and a laser range finder for intersatellite distance measurements.     

一种应用于实时深空干涉测量的电离层时延修正方法

针对"嫦娥4号"中继星任务S频段信标信号的高精度实时干涉测量需求,结合深空测控干涉测量系统采用的稀疏标校工作模式,研究验证了一种面向测控模式实时干涉测量的电离层时延修正方法。首先分析了电磁波经电离层传播的延迟机理及特性;基于深空站历史观测数据,通过自相关函数分析验证了天顶向TEC的周日特性;在此基础上,结合深空干涉测量中心数据处理设备软件系统,讨论了电离层时延修正方法;通过任务期间的实测数据处理分析,验证了所提方法可以将实时测量精度提升1～3 ns,对低仰角跟踪弧段,该技术方法优势更为明显。该方法为后续深入推进深空测控干涉测量系统在任务中的实时应用提供了技术储备。     

通用后置处理系统

对后置处理软件的通用化,模块化、标准化做了比较全面的、系统的分析和研究,并在此基础上提出了标准刀位文件和数据驱动式用户接口,为后置处理程序的商品化、工程化奠定了基础。     

一种基于模糊控制的平稳滑翔再入制导律

针对升力式高超声速飞行器(LHV)再入滑翔过程中的周期性振荡现象,提出了一种基于模糊推理与控制的反馈调节方法以抑制振荡实现平稳滑翔。纵向制导在落点误差预测及指令校正的基础上,在倾侧角外环控制回路增加以高度变化率及空速作为输入的模糊控制器对倾侧角指令进行调节,横侧向制导通过航向角误差走廊约束及倾侧角反转逻辑实现大横程条件下的侧向控制。所提方法不依赖于准平衡滑翔条件(QEGC),同时避免了参数化反馈控制律中的反馈项参数设计问题,具有较强的自适应能力。LHV制导实例仿真表明,所提方法可有效抑制振荡现象,满足终端约束及再入走廊约束,方法的鲁棒性也通过Monte Carlo仿真得到了验证。