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901.
T C Yang L M Craise M T Mei C A Tobias 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1989,9(10):131-140
Experimental data on molecular mechanisms are essential for understanding the bioeffects of radiation and for developing biophysical models, which can help in determining the shape of dose-response curves at very low doses, e.g., doses less than 1 cGy. Although it has been shown that ionizing radiation can cause neoplastic cell transformation directly, that high-LET heavy ions in general can be more effective than photons in transforming cells, and that the radiogenic cell transformation is a multi-step process [correction of processes], we know very little about the molecular nature of lesions important for cell transformation, the relationship between lethal and transformational damages, and the evolution of initial damages into final chromosomal aberrations which alter the growth control of cells. Using cultured mouse embryo cells (C3H10T1/2) as a model system, we have collected quantitative data on dose-response curves for heavy ions with various charges and energies. An analysis of these quantitative data suggested that two DNA breaks formed within 80 angstroms may cause cell transformation and that two DNA breaks formed within 20 angstroms may be lethal. Through studies with restriction enzymes which produce DNA damages at specific sites, we have found that DNA double strand breaks, including both blunt- and cohesive-ended breaks, can cause cell transformation in vitro. These results indicate that DNA double strand breaks can be important primary lesions for radiogenic cell transformation and that blunt-ended double strand breaks can form lethal as well as transformational damages due to misrepair or incomplete repair in the cell. The RBE-LET relationship is similar for HGPRT gene mutation, chromosomal deletion, and cell transformation, suggesting common lesions may be involved in these radiation effects. The high RBE of high-LET radiation for cell killing and neoplastic cell transformation is most likely related to its effectiveness in producing DNA double strand breaks in mammalian cells. At present the role of oncogenes in radiation cell transformation is unclear. 相似文献
902.
I. A. Crawford 《Space Policy》2004,20(2):91-97
It is over 30 years since the last human being stood on the lunar surface and this long hiatus in human exploration has been to the detriment of lunar and planetary science. The primary scientific importance of the Moon lies in the record it preserves of the early evolution of a terrestrial planet, and of the near-Earth cosmic environment in the first billion years or so of Solar System history. This record may not be preserved anywhere else; gaining proper access to it will require a human presence. Moreover, while this will primarily be a task for the geosciences, the astronomical and biological sciences would also benefit from a renewed human presence on the Moon, and especially from the establishment of a permanently occupied scientific outpost. 相似文献
903.
Powered by free-piston Stirling engines, linear alternators are proposed for space power stations as well as for isolated domestic applications, automotive, and on-Earth solar power plants. As the literature on the subject is sparse and base-design oriented, we present the general equations for both three-phase and single-phase winding configurations having permanent-magnet field excitations. 相似文献
904.
Two important elements in the avionics suite of modern aircraft are: the flight control system (FCS) and the flight management system (FMS). The FCS provides the capability to stabilize and control the aircraft, while the FMS is responsible for flight planning and navigation. A clear trend in the aerospace industry is to place greater reliance on software systems, and many FCS and FMS subsystems are implemented primarily in software. For example, within the FCS is the flight guidance system (FGS) that generates roll and pitch guidance commands. Similarly, within the FMS is the vertical navigation (VNAV) function that acts like a third crew member in the cockpit, ordering mode change requests and resetting target altitude values to enable the aircraft to track the vertical flight plan. We have developed formal, executable models of the requirements for the mode logic of a FGS and for portions of the VNAV functionality. We have also conducted a comprehensive software safety analysis on the FGS mode logic model, and are completing the analysis of the VNAV model. This analysis uses as its starting point several "traditional" safety analysis techniques such as a functional hazard assessment (FHA), a fault tree analysis (FTA), and a failure mode effects analysis (FMEA). However, we are also using formal methods techniques known as model checking and theorem proving to verify the presence of safety properties in the model. This paper summarizes the (now completed) safety analysis that was performed on the FGS model, and highlights the similarities and differences with the (still on-going) safety analysis of the FMS model. In particular, we summarize progress made to date in the use of formal methods to verify the presence of the required safety properties in the models themselves. 相似文献
905.
In the ASTRO-DABS concept for surveillance and data link, aircraft are interrogated by one of three geostationary transmitter satellites, each covering 1/3 of the contiguous United States. Interrogation scheduling involves a roll call such that aircraft responses to receiving satellites do not overlap (garble). A simple approach is developed which utilizes range ordering of aircraft with respect to transmitter satellites, but is independent of receiver satellite locations and aircraft distribution. Bounds on roll-call duration are established, showing that interrogation of 80 000 aircraft requires between 4.0 and 6.4 seconds with the ASTRO-DABS transmission format. If aircraft distribution is regionally concentrated (i.e., clustered), the roll-call duration nears the lower bound, since fewer gaps between interrogations are needed to preclude garbling. 相似文献
906.
The microwave CLFM study was directed to generating 14 ?s S-band pulses of 1000 MHz bandwidth and an rms phase error of a few degrees. Over 972 MHz bandwidth, the sampled phase error relative to the reference was 7 degrees rms and 17 degrees peak, with a maximum Fourier component of 4 degrees. The FM pulse train is generated by a gated BWO driven by a stable linearizing waveform. Phase coherency during each pulse is obtained by a sampling technique, where the phase is corrected at intervals of 1/6 ?s, the RF phase having changed an integral number of cycles in each interval. Multiplication of the BWO signal by the sampling pulse train results in band-limited phase error pulses which are applied in a feedback loop. Pulse-to-pulse coherency is obtained by phase lock of the BWO starting frequency to the crystal reference. Feedback leveling holds the output constant to 0.3 dB. The basic MITRE technique was originally demonstrated at 10 MHz in 1964. Range results measured with the X-band model radar using the CLFM generator are given and confirm the phase errors of the CLFM. 相似文献
907.
908.
During the conceptual design of a re-entry vehicle, the vehicle shape and geometry can be varied and its impact on performance can be evaluated. In this study, the shape optimization of two classes of vehicles has been studied: a capsule and a winged vehicle. Their aerodynamic characteristics were analyzed using local-inclination methods, automatically selected per vehicle segment. Entry trajectories down to Mach 3 were calculated assuming trimmed conditions. For the winged vehicle, which has both a body flap and elevons, a guidance algorithm to track a reference heat-rate was used. Multi-objective particle swarm optimization was used to optimize the shape using objectives related to mass, volume and range. The optimizations show a large variation in vehicle performance over the explored parameter space. Areas of very strong non-linearity are observed in the direct neighborhood of the two-dimensional Pareto fronts. This indicates the need for robust exploration of the influence of vehicle shapes on system performance during engineering trade-offs, which are performed during conceptual design. A number of important aspects of the influence of vehicle behavior on the Pareto fronts are observed and discussed. There is a nearly complete convergence to narrow-wing solutions for the winged vehicle. Also, it is found that imposing pitch-stability for the winged vehicle at all angles of attack results in vehicle shapes which require upward control surface deflections during the majority of the entry. 相似文献
909.
Gilbert D. Mead 《Space Science Reviews》1967,7(2-3):158-165
Theoretical studies of a field-free plasma incident upon a magnetic dipole lead to a closed magnetosphere with two neutral points in the noon magnetic meridian, at a latitude of ± 70°–75° and a geocentric distance of approximately 10 RE. The position of the neutral points with respect to the dipole axis is not greatly affected by the angle of incidence of the solar wind. Although the field magnitude near the neutral points is only a fraction of the dipole field, the direction is seen to reverse on opposite sides of the neutral point. Near the boundary the field direction is parallel to the boundary and tends to point towards the neutral point in the Northern hemisphere. 相似文献
910.
V. Gushin D. Shved A. Vinokhodova G. Vasylieva I. Nitchiporuk B. Ehmann L. Balazs 《Acta Astronautica》2012
“Mars-105” experiment was executed in March–July 2009 in Moscow, at the Institute for Bio-Medical Problems (IBMP) with participation of European Space Agency (ESA) to simulate some specific conditions of future piloted Mars mission. In the last 35 days of isolation, in order to simulate autonomous flight conditions, some serious restrictions were established for the crew resupply and communication with Mission Control (MC). The objective of the study was to investigate psychophysiological and behavioral aspects (communication) of adaptation during this period of “high autonomy”. We used computerized analysis of the crew written daily reports to calculate the frequencies of utilization of certain semantic units, expressing different psychological functions. To estimate the level of psycho-physiological stress, we measured the concentration of urinal cortisol once in two weeks. To investigate psycho-emotional state, we used the questionnaire SAN, estimating Mood, Activity and Health once in two weeks.During the simulation of autonomous flight, we found out the different tendencies of communicative behavior. One group of subjects demonstrated the tendency to “activation and self-government” under “high autonomy” conditions. The other subjects continued to use communicative strategy that we called “closing the communication channel”. “Active” communication strategy was accompanied by increasing in subjective scores of mood and activity. The subjects, whose communication strategy was attributed as “closing”, demonstrated the considerably lower subjective scores of mood and activity. Period of high autonomy causes specific changes in communication strategies of the isolated crew. 相似文献