Neutral buoyancy and sleep-deprived serum factors alter expression of cytokines regulating osteogenesis

We examined expression of genes associated with cytokine production, and genes implicated in regulating bone metabolism, in bone stromal and osteoblast cells incubated under standard ground conditions and under conditions of neutral buoyancy, and in the presence/absence of serum from normal or sleep-deprived mice. We observed a clear interaction between these two conditions (exposure to neutral buoyancy and serum stimulation) in promoting enhanced osteoclastogenesis. Both conditions independently altered expression of a number of cytokines implicated in the regulation of bone metabolism. However, using stromal cells from IL-1 and TNFx cytokine(r) KO mice, we concluded that the increased bone loss under microgravity conditions was not primarily cytokine mediated.     

Adaptive control and stabilization of elastic spacecraft

This work treats the question of large angle rotational maneuver and stabilization of an elastic spacecraft (spacecraft-beam-tip body configuration). It is assumed that the parameters of the system are completely unknown. An adaptive control law is derived for the rotational maneuver of the spacecraft. Using the adaptive controller, asymptotically decoupled control of the pitch angle of the space vehicle is accomplished, however this maneuver causes elastic deformation of the beam connecting the orbiter and tip body. For the stabilization of the zero dynamics (flexible dynamics), a stabilizer is designed using elastic mode velocity feedback. In the closed-loop system including the adaptive controller and the stabilizer, reference pitch angle trajectory tracking and vibration suppression are accomplished. Simulation results are presented to show the maneuver capability of the control system     

Interplanetary origin of geomagnetic storms

Around solar maximum, the dominant interplanetary phenomena causing intense magnetic storms (Dst<−100 nT) are the interplanetary manifestations of fast coronal mass ejections (CMEs). Two interplanetary structures are important for the development of storms, involving intense southward IMFs: the sheath region just behind the forward shock, and the CME ejecta itself. Whereas the initial phase of a storm is caused by the increase in plasma ram pressure associated with the increase in density and speed at and behind the shock (accompanied by a sudden impulse [SI] at Earth), the storm main phase is due to southward IMFs. If the fields are southward in both of the sheath and solar ejecta, two-step main phase storms can result and the storm intensity can be higher. The storm recovery phase begins when the IMF turns less southward, with delays of ≈1–2 hours, and has typically a decay time of 10 hours. For CMEs involving clouds the intensity of the core magnetic field and the amplitude of the speed of the cloud seems to be related, with a tendency that clouds which move at higher speeds also posses higher core magnetic field strengths, thus both contributing to the development of intense storms since those two parameters are important factors in genering the solar wind-magnetosphere coupling via the reconnection process. During solar minimum, high speed streams from coronal holes dominate the interplanetary medium activity. The high-density, low-speed streams associated with the heliospheric current sheet (HCS) plasma impinging upon the Earth's magnetosphere cause positive Dst values (storm initial phases if followed by main phases). In the absence of shocks, SIs are infrequent during this phase of the solar cycle. High-field regions called Corotating Interaction Regions (CIRs) are mainly created by the fast stream (emanating from a coronal hole) interaction with the HCS plasma sheet. However, because the B_z component is typically highly fluctuating within the CIRs, the main phases of the resultant magnetic storms typically have highly irregular profiles and are weaker. Storm recovery phases during this phase of the solar cycle are also quite different in that they can last from many days to weeks. The southward magnetic field (B_s) component of Alfvén waves in the high speed stream proper cause intermittent reconnection, intermittent substorm activity, and sporadic injections of plasma sheet energy into the outer portion of the ring current, prolonging its final decay to quiet day values. This continuous auroral activity is called High Intensity Long Duration Continuous AE Activity (HILDCAAs). Possible interplanetary mechanisms for the creation of very intense magnetic storms are discussed. We examine the effects of a combination of a long-duration southward sheath magnetic field, followed by a magnetic cloud B_s event. We also consider the effects of interplanetary shock events on the sheath plasma. Examination of profiles of very intense storms from 1957 to the present indicate that double, and sometimes triple, IMF B_s events are important causes of such events. We also discuss evidence that magnetic clouds with very intense core magnetic fields tend to have large velocities, thus implying large amplitude interplanetary electric fields that can drive very intense storms. Finally, we argue that a combination of complex interplanetary structures, involving in rare occasions the interplanetary manifestations of subsequent CMEs, can lead to extremely intense storms. This revised version was published online in June 2006 with corrections to the Cover Date.     

Beagle 2: a proposed exobiology lander for ESA's 2003 Mars Express mission.

The aim of the proposed Beagle 2 small lander for ESA's 2003 Mars Express mission is to search for organic material on and below the surface of Mars and to study the inorganic chemistry and mineralogy of the landing site. The lander will have a total mass of 60kg including entry, descent, and landing system. Experiments will be deployed on the surface using a robotic arm. It will use a mechanical mole and grinder to obtain samples from below the surface, under rocks, and inside rocks. Sample analysis by a mass spectrometer will include isotopic analysis. An optical microscope, an X-ray spectrometer and a Mossbauer spectrometer will conduct in-situ rock studies.     

Impact of Distance Determinations on Galactic Structure. I. Young and Intermediate-Age Tracers

Here we discuss impacts of distance determinations on the Galactic disk traced by relatively young objects. The Galactic disk, \(\sim40~\mbox{kpc}\) in diameter, is a cross-road of studies on the methods of measuring distances, interstellar extinction, evolution of galaxies, and other subjects of interest in astronomy. A proper treatment of interstellar extinction is, for example, crucial for estimating distances to stars in the disk outside the small range of the solar neighborhood. We’ll review the current status of relevant studies and discuss some new approaches to the extinction law. When the extinction law is reasonably constrained, distance indicators found in today and future surveys are telling us stellar distribution and more throughout the Galactic disk. Among several useful distance indicators, the focus of this review is Cepheids and open clusters (especially contact binaries in clusters). These tracers are particularly useful for addressing the metallicity gradient of the Galactic disk, an important feature for which comparison between observations and theoretical models can reveal the evolution of the disk.     

Assessment of precision in ionospheric electron density profiles retrieved by GPS radio occultations

The Constellation Observing System for Meteorology Ionosphere and Climate (COSMIC) is a six satellite radio occultation mission that was launched in April 2006. The close proximity of these satellites during some months after launch provides a unique opportunity to evaluate the precision of Global Positioning System (GPS) radio occultation (RO) retrievals of ionospheric electron density from nearly collocated and simultaneous observations. RO data from 30 consecutive days during July and August 2006 are divided into ten groups in terms of daytime or nighttime and latitude. In all cases, the best precision values (about 1%) are found at the F peak height and they slightly degrade upwards. For all daytime groups, it is seen that electron density profiles above about 120 km height exhibit a substantial improvement in precision. Nighttime groups are rather diverse: in particular, the precision becomes better than 10% above different levels between 120 and 200 km height. Our overall results show that up to 100–200 km (depending on each group), the uncertainty associated with the precision is in the order of the measured electron density values. Even worse, the retrieved values tend sometimes to be negative. Although we cannot rely directly on electron density values at these altitudes, the shape of the profiles could be indicative of some ionospheric features (e.g. waves and sporadic E layers). Above 200 km, the profiles of precision are qualitatively quite independent from daytime or latitude. From all the nearly collocated pairs studied, only 49 exhibited a difference between line of sight angles of both RO at the F peak height larger than 10°. After analyzing them we find no clear indications of a significant representativeness error in electron density profiles due to the spherical assumption above 120 km height. Differences in precision between setting and rising GPS RO may be attributed to the modification of the processing algorithms applied to rising cases during the initial period of the COSMIC mission.     

Investigation of ionospheric response to two moderate geomagnetic storms using GPS–TEC measurements in the South American and African sectors during the ascending phase of solar cycle 24

The responses of the ionospheric F region using GPS–TEC measurements during two moderate geomagnetic storms at equatorial, low-, and mid-latitude regions over the South American and African sectors in May 2010, during the ascending phase of solar cycle 24, are investigated. The first moderate geomagnetic storm studied reached a minimum Dst value of −64 nT at 1500 UT on 02 May 2010 and the second moderate geomagnetic storm reached a minimum Dst value of −85 nT at 1400 UT on 29 May 2010. In this paper, we present vertical total electron content (VTEC) and phase fluctuations (in TECU/min) from Global Positioning System (GPS) observations from the equatorial to mid-latitude regions in the South American and African sectors. Our results obtained during these two moderate geomagnetic storms from both sectors show significant positive ionospheric storms during daytime hours at the equatorial, low-, and mid-latitude regions during the main and recovery phases of the storms. The thermospheric wind circulation change towards the equator is a strong indicator that suggests an important mechanism is responsible for these positive phases at these regions. A pre-storm event that was observed in the African sector from low- to the mid-latitude regions on 01 May 2010 was absent in the South American sector. This study also showed that there was no generation or suppression of ionospheric irregularities by storm events. Therefore, knowledge about the suppression and generation of ionospheric irregularities during moderate geomagnetic storms is still unclear.     

Effects of solar modulation on the cosmic ray positron fraction

We implemented a 2D Monte Carlo model to simulate the solar modulation of galactic cosmic rays. The model is based on the Parker’s transport equation which contains diffusion, convection, particle drift and energy loss. Following the evolution in time of the solar activity, we are able to modulate a local interstellar spectrum (LIS), that we assumed isotropic beyond the termination shock, down to the Earth position inside the heliosphere. In this work we focused our attention to the cosmic ray positron fraction at energy below ∼10 GeV, showing how the particle drift processes could explain different results for AMS-01 and PAMELA. We compare our modulated spectra with observations at Earth, and then make a prediction of the cosmic ray positron fraction for the AMS-02 experiment.     

SSA: Where does Europe stand now?

With the growing need for monitoring and awareness of all the objects in space (including debris) now recognized, the types of effort required towards this end are discussed, with the emphasis on European activities. A number of European documents acknowledging the problem are cited and initiatives to promote space situational awareness (SSA) are examined. While there is currently no provision in the EU budget beyond 2013 for protecting ground and space assets from space environmental threats, an encouraging degree of bilateral cooperation between member states suggests that an SSA capability is emerging in Europe.