Autonomic function testing aboard the ISS using “PNEUMOCARD”

Investigations of blood pressure, heart rate (HR), and heart rate variability (HRV) during long term space flights on board the “ISS” have shown characteristic changes of autonomic cardiovascular control. Therefore, alterations of the autonomic nervous system occurring during spaceflight may be responsible for in- and post-flight disturbances. The device “Pneumocard” was developed to further investigate autonomic cardiovascular and respiratory function aboard the ISS. The hard-software diagnostic complex “Pneumocard” was used during in-flight experiment aboard ISS for autonomic function testing. ECG, photoplethysmography, respiration, transthoracic bioimpedance and seismocardiography were assessed in one male cosmonaut (flight lengths six month). Recordings were made prior to the flight, late during flight, and post-flight during spontaneous respiration and controlled respiration at different rates.HR remained stable during flight. The values were comparable to supine measurements on earth. Respiratory frequency and blood pressure decreased during flight. Post flight HR and BP values increased compared to in-flight data exceeding pre-flight values. Cardiac time intervals did not change dramatically during flight. Pulse wave transit time decreased during flight. The maximum of the first time derivative of the impedance cardiogram, which is highly correlated with stroke volume was not reduced in-flight.Our results demonstrate that autonomic function testing aboard the ISS using “Pneumocard” is feasible and generates data of good quality. Despite the decrease in BP, pulse wave transit time was found reduced in space as shown earlier. However, cardiac output did not decrease profoundly in the investigated cosmonaut.Autonomic testing during space flight detects individual changes in cardiovascular control and may add important information to standard medical control. The recent plans to support a flight to Mars, makes these kinds of observations all the more relevant and compelling.     

India's EO infrastructure for disaster reduction: Lessons and perspectives

India has established a ‘critical mass’ in terms of EO infrastructure for disaster management. Starting from IRS 1A in 1980s to the most recent CARTOSAT-2, India's EO series of satellites are moving away from the generic to thematic constellations. The series of RESOURCESAT, CARTOSAT, OCEANSAT and forthcoming Radar Imaging Satellite (RISAT) satellites exemplifies the thematic characters of the EO missions. These thematic constellations, characterized with multi-platform, multi-resolution and multi-parameter EO missions, are important assets for disaster reduction. In the more specific term, these constellations in conjunction with contemporary EO missions address the critical observational gaps in terms of capturing the catastrophic events, phenomena or their attributes on real/near real time basis with appropriate spatial and temporal attributes.Using conjunctively the data primarily emanating these thematic constellations and all weather radar data from aerial platform and also from RADARSAT as gap-fillers has been a part of India's EO strategy for disaster management. The infrastructure has been addressing the observational needs in disaster management. The high resolution imaging better than one-meter spatial resolution and also Digital Elevation Models (DEM) emanating from Cartosat series are providing valuable inputs to characterize geo-physical terrain vulnerability. Radar Imaging Satellite, with all weather capability missions, is being configured for disaster management. At present, the current Indian EO satellites cover the whole world every 40 h (with different resolutions and swaths), and the efforts are towards making it better than 24 h. The efforts are on to configure RESOURCESAT 3 with wider swath of 740 km with 23 m spatial resolution and also to have AWiFS type of capability at geo-platform to improve the observational frequencies for disaster monitoring.India's EO infrastructure has responded comprehensively to all the natural disasters the country has faced in the recent times. As a member of International Charter on Space and Major Disasters, India has also been instrumental in promoting the related UN initiatives viz., RESAP of UN ESCAP, SPIDER of UN OOSA, Sentinel Asia of JAXA initiative and also of GEOSS initiative. The paper intends to illustrate India's EO strategy for disaster reduction.     

Structure of the earth’s magnetosheath at small fluctuations in the interplanetary magnetic field direction

Spatial structure of the magnetosheath of the Earth was studied under the conditions when no sharp (more than 40° during 5 min) changes in the interplanetary magnetic field direction were observed. On the basis of 24 flights of the Interball-1 satellite through the magnetosheath, it is found that three regions differing from each other by parameters of the field and plasma can be observed in the magnetosheath under the above-indicated conditions. These regions also differ from the solar wind region before front of the Earth’s magnetospheric bow shock. Empirical distributions of parameters were studied in each region. Taking into account the influence of the interplanetary magnetic field direction on the processes in the magnetosheath, the cases of quasi-perpendicular and quasi-parallel shock waves were considered separately. The study showed that the distribution of parameters in the selected regions (in the solar wind before front of the bow shock, in the magnetosheath behind the bow shock (post-shock), in the region of the magnetosheath with minimal fluctuations in the field, and in the inner magnetosheath) differ from each other at any interplanetary magnetic field direction.     

Man and space – The Isle of Man, the IISC and the new space economy

With the arrival of private entrepreneurs and the appearance of such things as prizes to stimulate space initiatives, the space economy is changing rapidly from its initial government-driven character. A number of countries and territories, such as the Isle of Man, have understood the growing role of this new space economy and are preparing the appropriate boundary conditions to support its further development. This article shows why the Isle of Man may be uniquely placed to take advantage of recent developments in the space economy, thanks to its business-friendly tax and regulatory regime, and discusses the island’s strategy to attract space businesses. The establishment of the International Institute of Space Commerce, a recently formed think-tank, is an integral part of this strategy.     

Who’s supporting space activities? An ‘issue public’ for US space policy

Using data from the General Social Survey, this research identifies the issue public of US space policy. Highlighting the need to understand and identify the portion of the public that supports space activities, this study underscores the limited appeal of space for the public as a whole. We find that those who support space activities tend to be younger, male, Republican, and have a higher level of education and socioeconomic status. Because these characteristics make up a relatively small proportion of the American population, those supporting space activities must broaden the appeal of space, making it more accessible and understandable for those with whom the issue does not have much saliency.     

Space policy for late comer countries: A case study of South Korea

Korea’s space development program was created almost 40 years behind those of the advanced countries but it has nevertheless made remarkable progress. Korean space development has been focused on technology catch-up, where commercialization and growth of industrial competitiveness are important rationales. However, the program has several problems, including: lack of a space equipment manufacturing industry, total system companies in the space manufacturing industry and communication between industry and researchers, and much concentration of projects and initiatives in the Korean Aerospace Research Institute (KARI). This study analyzes the problem by comparing space agencies and programs in Korea and other countries, particularly Japan and the USA. It is shown that the role of a national laboratory is critical in space industry development and argued that KARI should make greater efforts to promote the Korean space industry by encouraging technology transfer, sharing equipment and communication between companies. For successful space development, the main organization – usually the national research institute – should change its role from a research-only laboratory to manager and supporter of space development and industry. Such a move would invigorate Korea’s space industry and allow it to catch up with countries with a similar environment.     

Thyrotropin receptor and membrane interactions in FRTL-5 thyroid cell strain in microgravity

The aim of this work was to analyze the possible alteration of thyrotropin (TSH) receptors in microgravity, which could explain the absence of thyroid cell proliferation in the space environment. Several forms of the TSH receptor are localized on the plasma membrane associated with caveolae and lipid rafts. The TSH regulates the fluidity of the cell membrane and the presence of its receptors in microdomains that are rich in sphingomyelin and cholesterol. TSH also stimulates cyclic adenosine monophosphate (cAMP) accumulation and cell proliferation. Reported here are the results of an experiment in which the FRTL-5 thyroid cell line was exposed to microgravity during the Texus-44 mission (launched February 7, 2008, from Kiruna, Sweden). When the parabolic flight brought the sounding rocket to an altitude of 264?km, the culture media were injected with or without TSH in the different samples, and weightlessness prevailed on board for 6 minutes and 19 seconds. Control experiments were performed, in parallel, in an onboard 1g centrifuge and on the ground in Kiruna laboratory. Cell morphology and function were analyzed. Results show that in microgravity conditions the cells do not respond to TSH treatment and present an irregular shape with condensed chromatin, a modification of the cell membrane with shedding of the TSH receptor in the culture medium, and an increase of sphingomyelin-synthase and Bax proteins. It is possible that real microgravity induces a rearrangement of specific sections of the cell membrane, which act as platforms for molecular receptors, thus influencing thyroid cell function in astronauts during space missions.     

Sunspot dynamics are reflected in human physiology and pathophysiology

Periodic episodes of increased sunspot activity (solar electromagnetic storms) occur with 10-11 and 5-6 year periodicities and may be associated with measurable biological events. We investigated whether this sunspot periodicity characterized the incidence of Pap smear-determined cervical epithelial histopathologies and human physiologic functions. From January 1983 through December 2003, monthly averages were obtained for solar flux and sunspot numbers; six infectious, premalignant and malignant changes in the cervical epithelium from 1,182,421 consecutive, serially independent, screening Pap smears (59°9″N, 4°29″E); and six human physiologic functions of a healthy man (oral temperature, pulse, systolic and diastolic blood pressure, respiration, and peak expiratory flow), which were measured ～5 times daily during ～34,500 self-measurement sessions (44°56″N, 93°8″W). After determining that sunspot numbers and solar flux, which were not annually rhythmic, occurred with a prominent 10-year and a less-prominent 5.75-year periodicity during this 21-year study span, each biological data set was analyzed with the same curve-fitting procedures. All six annually rhythmic Pap smear-detected infectious, premalignant and malignant cervical epithelial pathologies showed strong 10-year and weaker 5.75-year cycles, as did all six self-measured, annually rhythmic, physiologic functions. The phases (maxima) for the six histopathologic findings and five of six physiologic measurements were very near, or within, the first two quarters following the 10-year solar maxima. These findings add to the growing evidence that solar magnetic storm periodicities are mirrored by cyclic phase-locked rhythms of similar period length or lengths in human physiology and pathophysiology.