Effects of microgravity on c-fos gene expression in osteoblast-like MC3T3-E1 cells.

The paper summarizes the data on proliferation and gravity-related gene expression of osteoblasts that were obtained from an experiment conducted under simulated and real microgravity conditions. Simulated microgravity conditions obtained in a clinostat depress proliferation of both osteoblast-like MC3T3-E1 and HeLa carcinoma cells. This depression of proliferation occurs in a collagen gel culture in which the flow of culture medium by rotation may be reduced. Interestingly, MC3T3-E1 cells which are probably one of target cells to microgravity are more sensitive than the HeLa cells. Simulated microgravity inhibited the epidermal growth factor (EGF)-induced c-fos gene expression in the MC3T3-El cells. To examine in detail the effect of real microgravity on the EGF signal transduction cascade in osteoblasts, MC3T3-E1 cells were cultured in the Cell Culture Experiment Module of the sounding rocket TR-1A6. The EGF-induced c-fos expression in cells was depressed under short-term microgravity conditions in the sounding rocket, while the phosphorylation of mitogen-activated protein kinase (MAPK) was not affected compared with the controls grown on the ground. These results suggest that an action site of microgravity in the signal transduction pathway may be downstream of MAPK.     

New insights into Titan's organic chemistry in the gas and aerosol phases.

Titan, the largest satellite of Saturn, with a dense atmosphere very rich in organics, and many couplings in the various parts of its "geofluid", is a reference for studying prebiotic chemistry on a planetary scale. New data have been obtained from experiments simulating this organic chemistry (gas and aerosol phases), within the right ranges of temperature and a careful avoiding of any chemical contamination. They show a very good agreement with the observational data, demonstrating for the first time the formation of all the organic species already detected in Titan atmosphere including, at last, C4N2, together with many other species not yet detected in Titan. This strongly suggests the presence of more complex organics in Titan's atmosphere and surface, including high molecular weight polyynes and cyanopolyynes. The NASA-ESA Cassini-Huygens mission has been successfully launched in October 1997. The Cassini spacecraft will reach the Saturn system in 2004 and become an orbiter around Saturn, while the Huygens probe will penetrate into Titan's atmosphere. In situ measurements, in particular from Huygens GC-MS and ACP instruments, will provide a detailed analysis of the organics present in the air, aerosols, and surface. This very ambitious mission should yield much information of crucial importance for our knowledge of the complexity of Titan's chemistry, and, more generally for the field of exobiology.     

A concept of increasing efficiency for ramjet operation

The vortical mixing concept in the ramjet channel is analyzed. The results of simulating the gasodynamic scheme permit the concept of increasing efficiency for ramjet operation to be substantiated.     

Onboard system for measuring the parameters of wind vector during parking,starting and takeoff-landing modes for helicopter with aerometric and ion-beacon measuring channels

The problem and features of measuring the speed and the direction angle of the wind vector relative to the longitudinal helicopter axis during parking, starting and takeoff-landing modes by onboard means are considered. The construction principles, information processing algorithms and advantages of onboard system for measuring the wind vector parameters based on ion-beacon and aerometric measuring channels, are disclosed.     

The Lightning And Radio Emission Detector (LRD) instrument

The Lightning and Radio Emission Detector (LRD) instrument will be carried by the Galileo Probe into Jupiter's atmosphere. The LRD will verify the existence of lightning in the atmosphere and will determine the details of many of its basic characteristics. The instrument, operated in its magnetospheric mode at distances of about 5, 4, 3, and 2 planetary radii from Jupiter's center, will also measure the radio frequency (RF) noise spectrum in Jupiter's magnetosphere. The LRD instrument is composed of a ferritecore radio frequency antenna ( 100 Hz to 100 kHz) and two photodiodes mounted behind individual fisheye lenses. The output of the RF antenna is analyzed both separately and in coincidence with the optical signals from the photodiodes. The RF antenna provides data both in the frequency domain (with three narrow-band channels, primarily for deducing the physical properties of distant lightning) and in the time domain with a priority scheme (primarily for determining from individual RF waveforms the physical properties of closeby-lightning).     

Single-phase power distribution system power flow and faultanalysis

Alternative methods for power flow and fault analysis of single-phase distribution systems are presented. The algorithms for both power flow and fault analysis utilize a generalized approach to network modeling. The generalized admittance matrix, formed using elements of linear graph theory, is an accurate network model for all possible single-phase network configurations. Unlike the standard nodal admittance matrix formulation algorithms, the generalized approach uses generalized component models for the transmission line and transformer. The standard assumption of a common node voltage reference point is not required to construct the generalized admittance matrix. Therefore, truly accurate simulation results can be obtained for networks that cannot be modeled using traditional techniques     

Comments with reply, on `A new look at nonseparable syntheticaperture radar processing' by A. Di Cenzo

The commenters point out that the idea using a two-dimensional digital correlation technique to perform synthetic-aperture-radar (SAR) processing, presented as new in the above-titled paper (see ibid., vol.24, p.218-23, May 1988), was described by them as early as 1978 and has since been described by other authors. They discuss some of these earlier studies. The author replies that he was unaware of the earlier work, and that he did not intend to convey the impression that the nonseparable transform domain processor that he presented was the first     

Evolution of low-mass stars. implications for the dark matter distribution in the halo

We present up-to-date evolutionary models of low-mass stars, from M0.6 M down to the hydrogen burning minimum mass, using recent equation of state and synthetic spectra calculations. Comparison is made with observed luminosity function for these objects. We also present implications for the dark-matter distribution in the galactic halo.     

The impact of semi-convection and overshooting on the surface abundances in massive stars

We analyse the effects of semi-convection and overshooting on the predicted surface abundances after the first and second dredge-ups in 15 and 20 M Pop. I stars. Overshooting is applied either to the core boundary or to the boundaries of all convective zones. It is shown that the surface abundances are sensitive to the mixing scheme adopted in the interior. The models including semi-convection lead to lower¹²C/¹³C ratios than the other mixing schemes, while models with overshooting predict higher enhancements of sodium at the surface.     

Forward error correction for radiobeacon broadcast of differentialGPS data

Marine radiobeacon networks are being used to broadcast differential Global Positioning System (DGPS) corrections to marine users. The correction data digitally modulate signals from some of the existing marine radiobeacons, which operate in the 285 to 325 kHz band, creating DGPS/radiobeacons. The corrections improve the accuracy of the GPS fix from 100 m to 5-10 m, and provide position fixing service for many marine applications which are too demanding for the normal GPS service. Forward error correction can be used to improve the reliability or range of the DGPS/radiobeacon signal. The improvements made possible by channel coding are analyzed, and a code for DGPS/radiobeacons is recommended