Residual chromatin breaks as biodosimetry for cell killing by carbon ions

We have studied the relationship between cell killing and the induction of residual chromatin breaks on various human cell lines and primary cultured cells obtained by biopsy from patients irradiated with either X-rays or heavy-ion beams to identify potential bio-marker of radiosensitivity for radiation-induced cell killing. The carbon-ion beams were accelerated with the Heavy Ion Medical Accelerator in Chiba (HIMAC). Six primary cultures obtained by biopsy from 6 patients with carcinoma of the cervix were irradiated with two different mono-LET beams (LET= 13 keV/μm, 76 keV/μm) and 200kV X rays. Residual chromatin breaks were measured by counting the number of non-rejoining chromatin fragments detected by the premature chromosome condensation (PCC) technique after a 24 hour postirradiation incubation period. The induction rate of residual chromatin breaks per cell per Gy was the highest for 76 keV/μm beams on all of the cells. Our results indicated that cell which was more sensitive to the cell killing was similarly more susceptible to induction of residual chromatin breaks. Furthermore there is a good correlation between these two end points in various cell lines and primary cultured cells. This suggests that the detection of residual chromatin breaks by the PCC technique may be useful as a predictive assay of tumor response to cancer radiotherapy.     

蜂窝夹层结构弯曲疲劳寿命预测研究

复合材料夹层板兼具轻质高承载特性,但也面临多样的失效模式,深入研究其性能与失效机理,对确保结构安全与效能至关重要.针对一种玻璃纤维/氰酸酯织物层压面板和Nomex蜂窝复合的夹层板,采用特殊设计的试验夹具,开展三点弯曲静力和疲劳试验,分析该夹层板的弯—剪承载特性,观察其疲劳损伤和失效现象;同时,根据夹层板承力特点,对受面内力的面板和受面外剪切的芯材分别建立疲劳损伤模型,借助夹层板等效有限元模型,预测夹层板弯曲疲劳寿命.结果表明:所推荐的预测方法能够合理地反映夹层板弯曲疲劳损伤过程,疲劳寿命预测结果略为保守,与实测寿命误差属于可接受范围.     

Ulysses out-of-ecliptic observations of “27-day” variations in high energy cosmic ray intensity

We report the discovery that for latitudes above 40°S, the observed recurring modulation of cosmic rays and anomalous nuclei occurs without the detection byUlysses of the solar wind velocity and magnetic field recurring enhancements that have, heretofore at lower latitudes, defined corotating interaction regions—i.e., the mechanism producing the recurring intensity variations >40°S appears to be located beyond the radial range ofUlysses.     

收敛形进气道数值研究的验证

介绍一种新型的、具有最小喉道面积的三维高超声速进气道(称之为收敛形进气道)的数值和实验研究结果.表明使用这种形式的进气道,在整个飞行速度范围内可以降低阻力和高超声速发动机表面的热防护要求,通过降低外压缩表面的倾斜度和减少进气道及燃烧室壁的面积就可以做到这一点.在采用低维次流动的气体动力设计方法的基础上设计成这种形式的进气道.计算是在无粘气体模型构架内用有限体积法进行的.同时用边界层方程计算出计及粘性的气流特性和进气道特性.数值算法是通过收敛形进气道的有限宽楔形外压缩表面的计算和实验数据来验证的.进行实验研究的马赫数M=2~10.7,基于模型进气道高度的雷诺数Re=(1~5)×106. 数值计算与实验结果一致性很好.这些结果也和通常的二维进气道的数据作了比较.     

Synthesizing the control system of a small gliding unmanned aerial vehicle with high-aspect ratio wing

In this paper, we consider a problem of synthesizing the control system of a small gliding (unpowered) aerial vehicle (GAV) with a high-aspect ratio wing (?? ?? 10). This wing makes it possible to increase significantly the flight range and improve the maneuvering characteristics of the aerial vehicle itself.     

UV photobiochemistry under space conditions

The response of spores of Bacillus subtilis, cells of Deinococcus radiodurans and conidia of Aspergillus ochraceus to actual and simulated space conditions (UV in combination with long-term exposure to extremely dry conditions, including vacuum) has been studied: The following effects have been analyzed: decrease of viability, occurrence of DNA double strand breaks, formation of DNA-protein cross-links and DNA-DNA cross-links. All organisms show an increased sensitivity to UV light in extreme dryness (dry argon or vacuum) compared to an irradiation in aqueous suspension. The UV irradiation leads in all cases to a variety of DNA lesions. Very conspicuous is the occurrence of double strand breaks. Most of these double strand breaks are produced by incomplete repair of other lesions, especially base damages. The increase in DNA lesions can be correlated to the loss in viability. The specific response of the chromosomal DNA to UV irradiation in extreme dryness, however, varies from species to species and depends on the state of dehydration. The formation of DNA double strand breaks and DNA-protein cross-links prevails in the case of B. subtilis spores. In cells of Deinococcus radiodurans DNA-DNA cross-links often predominate, in conidia of Aspergillus ochraceus double strand breaks. The results obtained by direct exposure to space conditions (EURECA mission and D2 mission) largely agree with the laboratory data.     

A technique for estimating the probability of radiation-stimulated failures of integrated microcircuits in low-intensity radiation fields: Application to the Spektr-R spacecraft

In developing radio-electronic devices (RED) of spacecraft operating in the fields of ionizing radiation in space, one of the most important problems is the correct estimation of their radiation tolerance. The “weakest link” in the element base of onboard microelectronic devices under radiation effect is the integrated microcircuits (IMC), especially of large scale (LSI) and very large scale (VLSI) degree of integration. The main characteristic of IMC, which is taken into account when making decisions on using some particular type of IMC in the onboard RED, is the probability of non-failure operation (NFO) at the end of the spacecraft’s lifetime. It should be noted that, until now, the NFO has been calculated only from the reliability characteristics, disregarding the radiation effect. This paper presents the so-called “reliability” approach to determination of radiation tolerance of IMC, which allows one to estimate the probability of non-failure operation of various types of IMC with due account of radiation-stimulated dose failures. The described technique is applied to RED onboard the Spektr-R spacecraft to be launched in 2007.