End-to-End Modeling of the Solar Terrestrial System

Traditionally modeling for space science has concentrated on developing simulations for individual components of the solar terrestrial system. In reality these regions are coupled together. This coupling can be as simple as the driving of the magnetosphere – ionosphere – thermosphere system by the solar wind or as a complicated as the feedback of the ionospheric conductivity and currents on the magnetosphere. As part of the CISM project we are beginning a concentrated effort to compressively model the entire system. This approach includes chains of models. In the first chain physics based numerical models are utilized while in the second chain empirical models are coupled together. The first half of this paper discusses the numerical modeling approach by highlighting the coupling of pairs of regions within the system. In the second section we present results from empirical models which are combined to make long term forecasts of conditions in the geospace environment. It is expected that a validated and reliable forecast model for space weather can be obtained by combining the strongest elements of each chain.     

Residual chromatin breaks as biodosimetry for cell killing by carbon ions

We have studied the relationship between cell killing and the induction of residual chromatin breaks on various human cell lines and primary cultured cells obtained by biopsy from patients irradiated with either X-rays or heavy-ion beams to identify potential bio-marker of radiosensitivity for radiation-induced cell killing. The carbon-ion beams were accelerated with the Heavy Ion Medical Accelerator in Chiba (HIMAC). Six primary cultures obtained by biopsy from 6 patients with carcinoma of the cervix were irradiated with two different mono-LET beams (LET= 13 keV/μm, 76 keV/μm) and 200kV X rays. Residual chromatin breaks were measured by counting the number of non-rejoining chromatin fragments detected by the premature chromosome condensation (PCC) technique after a 24 hour postirradiation incubation period. The induction rate of residual chromatin breaks per cell per Gy was the highest for 76 keV/μm beams on all of the cells. Our results indicated that cell which was more sensitive to the cell killing was similarly more susceptible to induction of residual chromatin breaks. Furthermore there is a good correlation between these two end points in various cell lines and primary cultured cells. This suggests that the detection of residual chromatin breaks by the PCC technique may be useful as a predictive assay of tumor response to cancer radiotherapy.     

Optimal aeroassisted return from high earth orbit with plane change

This paper gives a complete analysis of the problem of aeroassisted return from a high Earth orbit to a low Earth orbit with plane change. A discussion of pure propulsive maneuver leads to the necessary change for improvement of the fuel consumption by inserting in the middle of the trajectory an atmospheric phase to obtain all or part of the required plane change. The variational problem is reduced to a parametric optimization problem by using the known results in optimal impulsive transfer and solving the atmospheric turning problem for storage and use in the optimization process. The coupling effect between space maneuver and atmospheric maneuver is discussed. Depending on the values of the plane change i, the ratios of the radii, $\text{n =}\text{r}{}_1\text{r}{}_2$ between the orbits and $\text{a =}\text{r}{}_2\text{R}$ between the low orbit and the atmosphere, and the maximum lift-to-drag ratio E1 of the vehicle, the optimal maneuver can be pure propulsive or aeroassisted. For aeroassisted maneuver, the optimal mode can be parabolic, which requires only drag capability of the vehicle, or elliptic. In the elliptic mode, it can be by one-impulse for deorbit and one or two-impulse in postatmospheric flight, or by two-impulse for deorbit with only one impulse for final circularization. It is shown that whenever an impulse is applied, a plane change is made. The necessary conditions for the optimal split of the plane changes are derived and mechanized in a program routine for obtaining the solution.     

Closed Artificial ecosystems as a means of ecosystem studies for Earth and space needs.

Closed Artificial ecosystems (CAES) have good prospects for wide use as new means for quantitative studies of different types of both natural ecosystems and man-made ones. The paper deals with the discussion of three points of CAES applications. The first one is of importance for theoretical ecology development and is connected with bringing together "holistic" and "merological" approaches in ecosystems studies. Using CAES, we can combine both approaches, taking into account the biotic turnover of limiting substrates which few in number even for complicated natural ecosystems. The second CAES use concerns the development of "ecosystems health" concept and application of a key-factor-approach for the indication and measurement of healthy unhealthy state and functioning of ecosystems or their links. The third use is more of an applied nature, oriented to the intensification of bioremediation or biodepollution processes in different types of ecosystems, including the global biosphere. Grant numbers: N 99-04-96017, N25.