Muscle atrophy associated with microgravity in rat: basic data for countermeasures

Morphological, contractile properties and myosin heavy chain (MHC) composition of rat soleus muscles were studied after 2 weeks of unloading (HS) and after 2 weeks of HS associated with selective deafferentation (HS + DEAF) at the level L4 and L5. The same significant reductions in muscle mass and tetanic tension were found after HS and HS + DEAF. However, the transformation of the slow-twitch soleus muscle towards a faster type characterized by a decrease in twitch time parameters and an increase in fast-twitch type MHC isoforms in HS did not appear in HS + DEAF conditions. Our results also showed that a pattern similar to firing rate of motoneurones innervating slow-twitch muscles inhibited the slow to fast fiber changes observed during HS. Nevertheless, neither the loss of mass or force output in the HS muscles were prevented by electrostimulation. Immobilization in a stretched position during HS maintained the muscle wet weight, mechanical and electrophoretical characteristics close to control values. We concluded that the decrease in mechanical strains imposed on the muscle during unloading was the main factor for the development of atrophy, while the kinetic changes might be predominantly modulated by the nervous command. These basic data suggested that some experimental conditions such as electrostimulation or stretching, could participate in countermeasure programmes.     

Effect of fluid and salt supplements in preventing the development of "osteopenia" in hypokinetic rats

It has been suggested that a daily intake of fluid and salt supplements may be used to prevent bone demineralization in human subjects after prolonged exposure to hypokinesia (diminished muscular activity). Thus, the objective of this investigation was to evaluate the effect of fluid and salt supplementation in the prevention of development of osteoporosis in 64 Wistar rats with an initial body weight of 339-345 g, after exposure to 90 days of hypokinesia. They divided into 4 equal groups: the first group of rats placed under ordinary vivarium conditions and served as vivarium control; the second group were also placed under ordinary vivarium conditions but received daily fluid and salt supplements; the third group were subjected to pure hypokinesia, i.e. without the use of any preventive measures; and the fourth group were submitted to hypokinesia and received daily fluid and salt supplements. For the simulation of the hypokinetic effect the experimental group of rats were kept in small, individual, wooden cages. Through the experimental period the second and fourth group of rats received 8 ml/100 g body wt water and 5 ml 100 g body wt NaCl daily. By the end of the experimental period the animals were decapitated and the spongy matter of tibia and vertebrae of the rats were examined for changes referable to osteoporosis. It was found that the daily intake of fluid and salt supplements caused an increase in the volume density of primary spongiosa of bones. It was concluded that a daily intake of fluid and salt supplements may be used to prevent the development of osteoporosis in rats subjected to prolonged motor activity restriction.     

The effect of small vibrations on Marangoni convection and the free surface of a liquid bridge

The effects of small vibrations on Marangoni convection were investigated experimentally using a liquid bridge of 5 cSt silicone oil with a disk diameter of 7.0 mm, and an aspect ratio close to 0.5. Experiments were performed to determine the critical temperature difference data for no vibration case and with small vibrations applied. The experimental results have shown that the effect of small vibrations on the onset of oscillatory flow is small since the critical temperature difference data for different aspect ratios were not affected by the vibrations. To clarify the surface oscillation phenomena induced by external vibrations, a 3-D numerical simulation model was also developed using a level set algorithm to predict the surface oscillations of isothermal silicone oil bridges. By subjecting the liquid bridge to small vibrations, the surface oscillation characteristics were predicted numerically, and the numerical results compared well with the predictions of an analytical model proposed previously. Furthermore, the effect of small vibrations on the surface vibration amplitude of the liquid bridge is also discussed.     

Precipitating Protons and Their Role in Ionization of the Polar Ionosphere

Spatial distributions of the electron density in the latitude range 60°–90° N were calculated on the basis of a physical model of the E and lower Fregions of the high-latitude ionosphere using statistical models of auroral proton and electron precipitation. It is shown that precipitating protons can play the key role in the ionization of the Eregion in the dusk and midnight sectors of the auroral oval. However, quantitative estimates of the contribution of protons to the ionization depend on the used statistical models of electron precipitation. Comparison of the electron density profiles calculated for two incoherent scatter radars, EISCAT (Tromsö) and ESR (Svalbard), for simultaneous precipitation of electrons and protons and for electron precipitation only show that the influence of protons is the most significant in the dusk sector over the EISCAT radar and in the midnight sector over the ESR radar. The results presented indicate the need to take protons into account when radar data are used to derive precipitating electron spectra.     

Tether Satellite System Collision Study

A study was performed to determine the probability of collision with resident space objects and untrackable debris for the tether component of the Tethered Satellite System (TSS) after it broke away from the Space Shuttle orbiter (mission STS-75) in February 1996. Both an analytical and a numerical approach were used in this study, and the results obtained with these two methods were found to be in good agreement. These results show that the deployed tether is expected to have been impacted by several particles 0.1mm or larger in size. The probability of collision with objects 10cm in size or larger was on the order of 10^–3 per month. Since the severed tether reentered within one month after deployment, the collision hazard to other objects while in orbit was small. The analytical methods used in this study are useful for tether collision evaluations in general.     

Geometric reasoning under uncertainty for map-based localization

Map-based navigation in outdoor terrain lacking man-made structures or other highly distinctive landmarks can produce severe localization problems. This paper presents an approach to navigation which implements high level geometric reasoning and matching strategies based on those used by skilled human navigators. This approach, which is demonstrated on a real example involving imagery of mountainous terrain obtained with a video camera and USGS map data, is designed to avoid many of the pitfalls occurring when an attempt is made to navigate by modeling the environment mathematically. It exploits feature attributes which cannot be easily expressed quantitatively but are central to the successful human navigation process.     

The Brazilian scientific microsatellite SACI-1

The National Space Research Institute (INPE) is developing the first Brazilian Scientific Microsatellite (SACI-1) based on the vanguard technology and on the experience acquired through projects developed by Brazilian Space Program. The SACI-1 is a 750km polar orbit satellite. The spacecraft will combine spin stabilization with geomagnetic control and has a total mass of 60 kg. The overall dimensions are 640×470×470 mm. The SACI-1 satellite shall be launched together with CBERS (China-Brazil Earth Resource Satellite). Its platform is being designed for multiple mission applications. The Brazilian Academy of Sciences has selected four scientific payloads that characterize the mission. The scientific experiments are: ORCAS (Solar and Anomalous Cosmic Rays Observation in the Magnetosphere), PLASMEX (Study of Plasma Bubbles), FOTSAT (Airglow Photometer), and MAGNEX (Geomagnetic Experiment).     

Mars Direct: Humans to the red planet by 1999

“Mars Direct”, is an approach to the space Exploration Initiative that allows for the rapid initiation of manned Mars exploration, possibly as early as 1999. The approach does not require any on-orbit assembly or refueling or any support from the Space Station or other orbital infrastructure. Furthermore, the Mars Direct plan is not merely a “flags and footprints” one-shot expedition, but puts into place immediately an economical method of Earth-Mars transportation, real surface exploratory mobility, and significant base capabilities that can evolve into a mostly self-sufficient Mars settlement. This paper presents both the initial and evolutionary phases of the Mars Direct plan. In the initial phase, only chemical propulsion is used, sendig 4 persons on conjunction class Mars exploratory missions. Two heavy lift booster launches are required to support each mission. The first launch delivers an unfueled Earth Return Vehicle (ERV) to the martian surface, where it fills itself with methane/oxygen bipropellant manufactured primarily out of indigenous resources. After propellant production is completed, a second launch delivers the crew to the prepared site, where they conduct regional exploration for 1.5 years and then return directly to Earth in the ERV. In the second phase of Mars Direct, nuclear thermal propulsion is used to cut crew transit times in half, increase cargo delivery capacity, and to create the potential for true global mobility through the use of CO₂ propelled ballistic hopping vehicles (“NIMFs”). In this paper we present both phases of the Mars Direct plan, including mission architecture, vehicle designs, and exploratory strategy leading to the establishment of a 48 person permanent Mars base. Some speculative thoughts on the possibility of actually colonizing Mars are also presented.     

Drying as one of the extreme factors for the microflora of the atmosphere

An investigation of the effects of drying and drying-rewetting cycles under vacuum conditions of 10(-2) torr at -30 degrees C on conidia of the atmospheric strain Penicillium chrysogenum from 48-77 km heights, collected by meteorological rockets found that survival and restoration of the initial physiological properties were possible through some very efficient protective cellular mechanisms. Such adaptive possibilities explain the widespread diffusion of microbial cells throughout the biosphere of our planet.     

Anesthesia, surgical aid and resuscitation in manned space missions.

When discussing problems related to medical service in space flight, particular attention should be given to the specific living conditions and changes associated with space flight. In disease and injury, surgery can be provided only after conservative therapy has failed. In this context gnotobiological chambers allowing surgery in aseptic conditions seem promising. A portable set of interchangeable surgical tools should be made of light-weight alloys that can be readily sterilized. Electroanalgesia in combination with auriculoacupuncture as well as peridureal anesthesia may be used as they allow normal operations in autonomous space flight conditions. Changes in the sympatho-adrenal and kallikrein-kinin systems, as well as water-electrolyte balance, should be taken into account in developing methods and means of medical service in critical situations. Special attention should be given to the prevention and treatment of brain edema in view of weightlessness-induced cephalad fluid shifts.