A method of airfoil shape completing

An iteration method for airfoil shape completing using the pressure coefficient distribution specified on its sought part is proposed. The incompressible flow viscosity is taken into account by the boundary layer model, the iteration process is constructed with the use of G.Yu. Stepanov’s idea. The solution algorithm is compiled and a set of numerical calculations is carried out. It is shown that the method proposed offers advantages over the well-known numerical-analytical scheme of solving mixed inverse boundary-value problems of aerohydrodynamics in the case of viscous incompressible fluid.     

Mathematical description of the NaK model for MASTER-2005

The release of NaK droplets has been modeled for the new version of the European Meteoroid and Space Debris Terrestrial Environment Reference model MASTER-2005. Previously published versions of the model have been revised. The parameters of the model are introduced and discussed. NaK droplets consist of eutectic sodium–potassium alloy and have been released during RORSAT reactor core ejections. They contributed to the space debris environment in the centimeter and millimeter size regime. Sixteen nuclear powered RORSATs launched between 1980 and 1988 activated a reactor core ejection system in Sufficiently High Orbits (SHO), mostly between 900 and 950 km altitude. The core ejection caused an opening of the primary coolant circuit. The liquid coolant has been released into space during these core ejections. The outflow is considered as a discrete event for each of the sixteen core ejections in total. The NaK coolant has been forming droplets up to a diameter of 5.5 cm. NaK releases are restricted to a very narrow region near 65° inclination. This paper gives the parameters of the NaK release model as it is implemented in MASTER-2005. The quantitative values of all model parameters including characteristic diameter and uniformity parameter are presented. The ratio of the characteristic droplet size to the orifice diameter is discussed. It is estimated that altogether 128 kg of NaK-78 (8 kg per RORSAT) was released on orbit. Simulation runs show that there are still 45,000 droplets with a total mass of 97 kg in orbit at the reference epoch 1 May 2005, whereas the smallest droplet has a diameter of 5 mm. Results of orbit propagation simulation runs are presented in terms of spatial density.     

SAMBO-GEOS: On three-dimensional substorm dynamics — A case study for 4 March 1979

For investigations of the isolated magnetospheric substorm the ground-based and satellite geophysical data are discussed. The active phase of the substorm has two parts: an active-convective phase and a classical active phase. The analysed data show that the breakup of the substorm takes place at closed and not very much stretched magnetic field lines.     

Neoplastic cell transformation by high-LET radiation: molecular mechanisms.

Experimental data on molecular mechanisms are essential for understanding the bioeffects of radiation and for developing biophysical models, which can help in determining the shape of dose-response curves at very low doses, e.g., doses less than 1 cGy. Although it has been shown that ionizing radiation can cause neoplastic cell transformation directly, that high-LET heavy ions in general can be more effective than photons in transforming cells, and that the radiogenic cell transformation is a multi-step process [correction of processes], we know very little about the molecular nature of lesions important for cell transformation, the relationship between lethal and transformational damages, and the evolution of initial damages into final chromosomal aberrations which alter the growth control of cells. Using cultured mouse embryo cells (C3H10T1/2) as a model system, we have collected quantitative data on dose-response curves for heavy ions with various charges and energies. An analysis of these quantitative data suggested that two DNA breaks formed within 80 angstroms may cause cell transformation and that two DNA breaks formed within 20 angstroms may be lethal. Through studies with restriction enzymes which produce DNA damages at specific sites, we have found that DNA double strand breaks, including both blunt- and cohesive-ended breaks, can cause cell transformation in vitro. These results indicate that DNA double strand breaks can be important primary lesions for radiogenic cell transformation and that blunt-ended double strand breaks can form lethal as well as transformational damages due to misrepair or incomplete repair in the cell. The RBE-LET relationship is similar for HGPRT gene mutation, chromosomal deletion, and cell transformation, suggesting common lesions may be involved in these radiation effects. The high RBE of high-LET radiation for cell killing and neoplastic cell transformation is most likely related to its effectiveness in producing DNA double strand breaks in mammalian cells. At present the role of oncogenes in radiation cell transformation is unclear.     

Neoplastic transformation of hamster embryo cells by heavy ions

We have studied the induction of morphological transformation of Syrian hamster embryo cells by low doses of heavy ions with different linear energy transfer (LET), ranging from 13 to 400 keV/μm. Exponentially growing cells were irradiated with ¹²C or ²⁸Si ion beams generated by the Heavy Ion Medical Accelerator in Chiba (HIMAC), inoculated to culture dishes, and transformed colonies were identified when the cells were densely stacked and showed a crisscross pattern. Over the LET range examined, the frequency of transformation induced by the heavy ions increased sharply at very low doses no greater than 5 cGy. The relative biological effectiveness (RBE) of the heavy ions relative to 250 kVp X-rays showed an initial increase with LET, reaching a maximum value of about 7 at 100 keV/μm, and then decreased with the further increase in LET. Thus, we confirmed that high LET heavy ions are significantly more effective than X-rays for the induction of in vitro cell transformation.     

Repair of DNA double-strand breaks and cell killing by charged particles.

It has been suggested that it is not simple double-strand breaks (dsb) but the non-reparable breaks which correlate well with the high biological effectiveness of high LET radiations for cell killing (Kelland et al., 1988; Radford, 1986). We have compared the effects of charged particles on cell death in 3 pairs of cell lines which are normal or defective in the repair of DNA dsbs. For the cell lines SL3-147, M10, and SX10 which are deficient in DNA dsb repair, RBE values were close to unity for cell killing induced by charged particles with linear energy transfer (LET) up to 200 keV/micrometer and were even smaller than unity for the LET region greater than 300 keV/micrometer. The inactivation cross section (ICS) increased with LET for all 3 pairs. The ICS of dsb repair deficient mutants was always larger than that of their parents for all the LET ranges, but with increasing LET the difference in ICS between the mutant and its parent became smaller. Since a small difference in ICS remained at LET of about 300 keV/micrometer, dsb repair may still take place at this high LET, even if its role is apparently small. These results suggest that the DNA repair system does not play a major role in protection against the attack of high LET radiations and that a main muse of cell death is non-reparable dsb which are produced at a higher yield compared with low LET radiations. No correlation was observed between DNA content or nuclear area and ICS.     

Numerical prediction and wind tunnel experiment for a pitching unmanned combat air vehicle

The low-speed flowfield for a generic unmanned combat air vehicle (UCAV) is investigated both experimentally and numerically. A wind tunnel experiment was conducted with the Boeing 1301 UCAV at a variety of angles of attack up to 70 degrees, both statically and with various frequencies of pitch oscillation (0.5, 1.0, and 2.0 Hz). In addition, pitching was performed about three longitudinal locations on the configuration (the nose, 35% MAC, and the tail). Solutions to the unsteady, laminar, compressible Navier–Stokes equations were obtained on an unstructured mesh to match results from the static and dynamic experiments. The computational results are compared with experimental results for both static and pitching cases. Details about the flowfield, including vortex formation and interaction, are shown and discussed, including the non-linear aerodynamic characteristics of the vehicle.     

Maps of hydrogen isotopes at low altitudes in the inner zone from sampex observations

The PET instrument aboard the SAMPEX satellite has provided us with long-term intra-calibrated observations of geomagnetically trapped protons and deuterons in the inner zone, suitable for use in constraining the low-altitude portions of radiation belt models being developed as successors to AP-8. These observations have been summarized elsewhere (Looper et al., 1996). Here we report a detection of geomagnetically-trapped tritium at energies from 14 to 35 MeV/nuc below L = 1.2, at about 1/8 the flux of deuterium previously reported at that location and at similar energy per nucleon. We also demonstrate the utility of the SAMPEX/PET observations for measuring the east-west anisotropy in the trapped particle flux at low altitudes, which is due to displacement of particle gyrocenters from the position of observation in a region of strong flux gradients. This anisotropy is implicitly ignored in omnidirectional radiation-flux models, but it can be important to mission planners considering how to distribute shielding over the surface of oriented spacecraft in low Earth orbit.     

Tissue responses to low protracted doses of high LET radiations or photons: early and late damage relevant to radio-protective countermeasures.

Early and late murine tissue responses to single or fractionated low doses of heavy charged particles, fission-spectrum neutrons or gamma rays are considered. Damage to the hematopoietic system is emphasized, but results on acute lethality, host response to challenge with transplanted leukemia cells and life-shortening are presented. Low dose rates per fraction were used in some neutron experiments. Split-dose lethality studies (LD 50/30) with fission neutrons indicated greater accumulation of injury during a 9 fraction course (over 17 days) than was the case for gamma-radiation. When total doses of 96 or 247 cGy of neutrons or gamma rays were given as a single dose or in 9 fractions, a significant sparing effect on femur CFU-S depression was observed for both radiation qualities during the first 11 days, but there was not an earlier return to normal with dose fractionation. During the 9 fraction sequence, a significant sparing effect of low dose rate on CFU-S depression was observed in both neutron and gamma-irradiated mice. CFU-S content at the end of the fractionation sequence did not correlate with measured LD 50/30. Sustained depression of femur and spleen CFU-S and a significant thrombocytopenia were observed when a total neutron dose of 240 cGy was given in 72 fractions over 24 weeks at low dose rates. The temporal aspects of CFU-S repopulation were different after a single versus fractionated neutron doses. The sustained reduction in the size of the CFU-S population was accompanied by an increase in the fraction in DNA synthesis. The proliferation characteristics and effects of age were different for radial CFU-S population closely associated with bone, compared with the axial population that can be readily aspirated from the femur. In aged irradiated animals, the CFU-S proliferation/redistribution response to typhoid vaccine showed both an age and radiation effect. After high single doses of neutrons or gamma rays, a significant age- and radiation-related deficiency in host defense mechanisms was detected by a shorter mean survival time following challenge with transplantable leukemia cells. Comparison of dose-response curves for life shortening after irradiation with fission-spectrum neutrons or high energy silicon particles indicated high initial slopes for both radiation qualities at low doses, but for higher doses of silicon, the effect per Gy decreased to a value similar to that for gamma rays. The two component life-shortening curve for silicon particles has implications for the potential efficacy of radioprotectants. Recent studies on protection against early and late effects by aminothiols, prostaglandins, and other compounds are discussed.