Skylab experiment results: hematology studies

These studies were designed and coordinated to evaluate specific aspects of man's immunologic and hematologic systems which might be altered by or respond to the space flight environment. The biochemical functions investigated included cytogenetic damage to blood cells, immune resistance to disease, regulation of plasma and red cell volumes, metabolic processes of the red blood cell, and physical chemical aspects of red blood cell functions. Only minor changes were observed in the functional capacity of erythrocytes as determined by measuring the concentrations of selected intracellular enzymes and metabolites. Tests of red cell osmotic regulation indicated some elevation in the activity of the metabolic dependent Na-K pump, with no significant alterations in the cellular Na and K concentrations or osmotic fragility. A transient shift in red cell specific-gravity profile was observed on recovery, possibly related to changes in cellular water content. Measurements of hemoconcentration (hematocrit, hemoglobin concentration, red cell count) indicated significant fluctuations postflight, reflecting observed changes in red cell mass and plasma volume. There was no apparent reticulocytosis during the 18 days following the first manned Skylab mission in spite of a significant loss in red cell mass. However, the reticulocyte count and index did increase significantly 5 to 7 days after completion of the second, longer duration, flight. There were no significant changes in either the while blood cell count or differential. However, the capacity of lymphocytes to respond to an in vitro mitogenic challenge was repressed postflight, and appeared to be related to mission duration. The cause of this repression is unknown at this time. Only minor differences were observed in plasma protein patterns. In the second mission there were changes in the proteins involved in the coagulation process which suggested a hypercoagulative condition.     

Theoretical consideration of the chemical pathways for radiation-induced strand breaks.

A theoretical approach to the understanding of the biochemical mechanisms of indirect action of ionizing radiation on SV40 DNA in aqueous solution is presented. The extent of OH attack on the sugar moiety and bases has been calculated. A realistic model for the DNA (in B form) based on available X-ray diffraction data is used and specific reaction sites for the OH radicals are obtained. A Monte Carlo scheme is used to follow the diffusion and reaction of the OH radicals. Effects of track structure have been considered and the single strand break D37 values for 14 MeV electrons (low-LET) and 670 MeV/u and 40 MeV/u neon particles are presented. Calculated results are in agreement with available experimental data. It has been found that regardless of the qualities of radiation, 80% of the OH attack on DNA is on the bases and 20% is on the deoxyribose. From probability considerations only, it appears that the number of double strand breaks varies linearly with dose.     

Crystallization of metal alloys in microgravity and uniform compression conditions

This is an analysis of the experimental results to study the metastable phase formation while crystallization of binary metal melts in microgravity and quasi-isostatic (uniform) compression takes place. The alloy system PbSn serves as an illustration     

Some Results on Digital Chirp

Generating chirp waveforms by means of phase coding yields a simple, cost-effective mechanization. The coding process, however, introduces phase errors whose effect must be included in the design. An approximate analysis is presented, valid for moderate to high compression ratios, which allows error effects on compressed pulse amplitude and sidelobes to be calculated in a simple manner. The anaylsis provides criteria for selecting the coding bit width (sample rate), weighting network bandwidth, and phase-coder quantization interval and transition times. Weighting functions for maximizing the signal-to-noise ratio (SNR) or for producing desired close-in sidelobe performance are derived, as is an exact expression for the transmitted spectrum. Numerical results are presented for Gaussian and the maximum-SNR weighting. The results indicate that performance will be satisfactory for many applications.     

A new calibration of the semi-empirical photometric theory for Halley and other comets

A massive new body of data, comprised of spectrophotometry of 17 comets by Newburn and Spinrad, has now become available for calibration of the basic theory, the Semi-Empirical Photometric Theory, used for modelling of Comet Halley. A redetermination of the constant $\text{R}$ and the function δ has been made, and no change is needed. Improved mixing ratios given as a function of heliocentric distance also permit an improvement in the constants of the visual photometric model presented at COSPAR XXIV. A new light curve for Halley and a lower dust to gas ratio prove to make roughly compensating changes in dust densities.     

An Analytical Expression for Correlation Accuracy

An analytical closed-form expression for the uncertainty in aligning two images is derived as a function of image area, data fidelity, scene correlation length, limiting sensor resolution length, and degree of geometrical distortion between the two images.     

A Multimedia Document Server

We describe issues related to the design and performance of a multimedia information server for an office environment. Multimedia documents are composed of text, image, voice, and attribute information. We describe the multimedia document structure, their internal representation and their presentation form. Content addressibility in this environment is achieved by specifying conditions on attributes, text, images, and document presentation form. Query reformulation, multimedia document formation in this environment and communication with the outside world are also discussed. Archived documents are stored in a centralized server. Users submit their queries in their local workstations using a local area network. The server retrieves the qualifying documents and returns them to the users. We analyze the performance of various access methods for multimedia documents that reside in the server.     

Effects due to an artificial earth satellite in rapid motion through the ionosphere or the interplanetary medium

Conclusion In this paper we have been concerned with the results of theoretical calculations of the interaction between a fast moving body and a tenuous plasma. Particular attention was paid to the case where the velocity of the body is much smaller than the velocity of neutral particles and ions, while the dimensions of the body are sufficiently large in comparison with the Debye radius. Such conditions are realized during the motion of artificial satellites or space rockets through the ionosphere, or through the interplanetary medium in the immediate neighborhood of the earth. Although this case has, on the whole, been investigated quite extensively, there are still a number of problems which require further analysis. Firstly, it is necessary to take into account the effect of the electric field on the motion of ions in the near zone at the rear of the body. Another important problem is that of magnetic disturbances. In the case of scattering of radio waves by the trail of the body, it would be interesting indeed to know the increase in the effective cross-section in the resonance region in which 0. A number of other research problems which arise in the analysis of phenomena in the neighborhood of a moving body have been noted in the Introduction.In the lower layers of the ionosphere it is important to allow for the fact that the dimensions of the body are comparable with the mean free path. Under these conditions there is the further interesting problem of the heating and additional ionization of the plasma, the disintegration of the surface, and the emission of waves. At large distances from the surface of the earth, the dimensions of the body may become comparable with the Debye radius, and the velocity of the body in the given region may become smaller than the thermal velocity of the particles. The character of the various disturbances introduced by the body under these conditions will also require a special investigation.Thus, the interaction of a moving body with plasma leads to special and exceptionally varied effects. Disturbances due to the body are very considerable, so that the physical state of the region surrounding the body is very different from the state of the undisturbed medium.The above results indicate that the phenomena in the neighborhood of satellites and space rockets in the ionosphere, or the interplanetary medium, must be taken into account, in the processing of experimental data when it is required to deduce information about the state of the undisturbed medium. This is particularly important in the analysis of the results of measurements obtained with various types of probes. Considerable errors may be introduced if these effects are not allowed for.Further extensive experimental and theoretical studies of the structure of the disturbed region in the neighborhood of moving bodies in plasma are clearly necessary. Such investigations will, in particular, lead to the development of the most effective methods of studying the properties of the media through which satellites and space rockets travel.Translated from the Russian: Ob effektah vyzyvaemyh iskusstvennym sputnikom bystro dviimsja v ionosfere ili meplanetnoj srede (Uspehi fizieskih nauk 79, 23–80) by Express Translation Service.     

Microprocessor-Controlled Communications in an Advanced Instrument Landing System

The application of 4-bit microprocessors to the communication of the control and status signals found in an advanced aircraft instrument landing system is presented. The advantages as well as some of the peculiarities of such an approach are described. Among the benefits, one must include the possibility of a very convenient and understandable human interface.