Abiogenic synthesis of pyrimidine nucleotides in solid state by vacuum ultraviolet radiation.

The abiogenic synthesis of pyrimidine nucleotides in solid state has been investigated. Our experiment indicates that natural nucleotides are produced in thin films prepared from nucleoside and inorganic phosphate by irradiating with vacuum ultraviolet light (VUV, lambda=100-200 nm). We have investigated the influence of the type of nucleic acids base (thymidine, cytosine, uracil) and the structure of sugar moiety (ribose or deoxyribose) on the course and yield of reaction. We compared the action of vacuum ultraviolet light with action of gamma-radiation, heat and biology significant UV (254 nm) which have been investigated earlier. The occurrence of these reaction in open space is discussed.     

Evaluation of EarthRadar unexploded ordnance testing at Fort A.P.Hill, Virginia

Previously, K. Bakhtar and E. Sagal [ibid. vol. 17, pp. 4-11, 2002] made remarkable claims for the performance of the Bakhtar Associates ground-penetrating radar (GPR) in detecting and classifying buried unexploded ordnance (UXO). In this article, we report the results of the series of blind tests on the EarthRadar carried out during the Fall of 2000 and Spring of 2001, which led to very different conclusions regarding the radar's performance. The contents of this article are excerpted from the final report on the testing, prepared by the Institute for Defense Analyses     

First radiobiological results of LDEF-1 experiment A0015 with Arabidopsis seed embryos and Sordaria fungus spores.

This article highlights the first results of investigations on the general vitality and damage endpoints caused by cosmic ionizing radiation in dry, dormant plant seeds of the crucifer plant Arabidopsis thaliana (L.) Heynh. and the ascomycete Sordaria fimicola after 69 month stay in space. Wild-type and mutant gene marker lines were included in Free Flyer Biostack containers and exposed on earth and side tray of the LDEF-1 satellite. The damage in biological endpoints observed in the seeds increased in the side tray sample compared to the earth tray sample. For the ascospores we found different effects depending on the biological endpoints investigated for both expositions.     

Estimation of risk based on multiple events in radiation carcinogenesis of rat skin.

In the multistage theory of carcinogenesis, cells progress to cancer through a series of discrete, irreversible, heritable genetic alterations or mutations. However data on radiation-induced cancer incidence in rat skin suggests that some part of an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to the following radiations: 1. an electron beam (LET=0.34 keV/um, 2. a neon ion beam (LET=25 keV/um and 3. an argon ion beam (LET=125 keV/um. The latter 2 beams were generated by the Bevalac at the Lawrence Berkeley Laboratory, Berkeley, CA. About 6.0 cm2 of skin was irradiated per rat. The rats were observed every 6 weeks for at least 78 weeks and tumors were scored at first occurrence. Several histological types of cancer, including squamous and basal cell carcinomas, were induced. The cancer yield versus radiation dose was fitted by the quadratic equation (Y(D)=CLD+BD2), and the parameters C and B were estimated for each type of radiation. Analysis of the DNA from the electron-induced carcinomas indicated that K-ras and/or c-myc oncogenes were activated in all tumors tested, although only a small proportion of neon-induced tumors showed similar activation. In situ hybridization indicated that the cancers contain subpopulations of cells with differing amounts of c-myc and H-ras amplification. The results are consistent with the idea that ionizing radiation produces carcinogenically relevant lesions via 2 repairable events at low LET and via a non-repairable, linked event pathway at high LET; either pathway may advance the cell by 1 stage in the multistage model. The model, if validated, permits the direct calculation of cancer risk in rat skin in a way that can be subjected to experimental testing.     

Particle trajectories in seeds of Lactuca sativa and chromosome aberrations after exposure to cosmic heavy ions on Cosmos Biosatellites 8 and 9.

The potentially specific importance of the heavy ions of the galactic cosmic radiation for radiation protection in manned spaceflight continues to stimulate in situ, i.e., spaceflight experiments to investigate their radiobiological properties. Chromosome aberrations as an expression of a direct assault on the genome are of particular interest in view of cancerogenesis being the primary radiation risk for man in space. In such investigations the establishment of the geometrical correlation between heavy ions' trajectories and the location of radiation sensitive biological substructures is an essential task. The overall qualitative and quantitative precision achieved for the identification of particle trajectories in the order of approximately 10 micrometers as well as the contributing sources of uncertainties are discussed. We describe how this was achieved for seeds of Lactuca sativa as biological test organisms, whose location and orientation had to be derived from contact photographies displaying their outlines and those of the holder plates only. The incidence of chromosome aberrations in cells exposed during the COSMOS 1887 (Biosatellite 8) and the COSMOS 2044 (Biosatellite 9) mission was determined for seeds hit by cosmic heavy ions. In those seeds the incidence of both single and multiple chromosome aberrations was enhanced. The results of the Biosatellite 9 experiment, however, are confounded by spaceflight effects unrelated to the passage of heavy ions.     

Current status, architecture, and future technologies for theInternational Space Station electric power system

The Electric Power System (EPS) being built for the International Space Station has undergone several significant changes over the last year, as major design decisions have been made for the overall station. While the basic topology and system elements have remained the same, there are important differences in connectivity, assembly sequence, and start-up. The key drivers for these changes in architecture have been the goal to simplify verification, and most significantly, the introduction of extensive Russian participation in the program. Having the Russians join the international community in this project has resulted in an expanded station size, larger crew, and almost doubled the observable surface of the Earth covered by the station. For the power system it has meant additional interfaces for power transfer, and new challenges for solar tracking at the higher inclination orbit. This paper reviews the current architecture and emphasizes the new features that have evolved, as the design for the new, larger station has developed. Additionally, the possible application of developing technology to the station, and other future missions is considered     

Neural networks in nonlinear aircraft flight control

This paper describes an approach for incorporating a neural network with real-time learning capability in a flight control architecture. The architecture is also applicable, in general, for the control of processes described by nonlinear differential equations of motion in which there exists a control for each degree of freedom. The main features are that the defining equations of motion for the process to be controlled are poorly known with respect to their functional forms, and that the functional forms, themselves, may undergo sudden and unexpected variation. It is well known that such systems are difficult to control, particularly when the effect of the control action enters nonlinearly. Numerical results based on 6DOF simulations of a high performance aircraft are presented to illustrate the potential benefits of incorporating neural networks as a part of a flight control system architecture     

Fuel cell technology status

Several major fuel cell projects and their status are described. The fuel cell types discussed are phosphoric acid, molten carbonate, solid oxide, and polymer. One of the technologies is very close to commercialization. Two others offer the possibility for higher efficiency and large capacity electric generation using coal. Still another may be the answer to the key issues facing the transportation sector     

Optimal radar threshold determination in Weibull clutter andGaussian noise

A technique is presented for determining the ideal detection threshold when Gaussian noise and Weibull distributed clutter returns are present on a radar receiver and neither is dominant. Quantitative data is presented for several clutter types and false alarm probabilities