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411.
    
High-affinity Na+-dependent glutamate transporters of the plasma membrane mediate the glutamate uptake into neurons, and thus maintain low levels of extracellular glutamate in the synaptic cleft. The study focused on the release of glutamate by reversal of Na+-dependent glutamate transporters from rat brain nerve terminals (synaptosomes) under conditions of centrifuge-induced hypergravity. Flow cytometric analysis revealed similarity in the size and cytoplasmic granularity between synaptosomal preparations obtained from control and G-loaded animals (10 G, 1 h). The release of cytosolic l-[14C]glutamate from synaptosomes was evaluated using the protonophore FCCP, which dissipated synaptic vesicle proton gradient, thus synaptic vesicles were not able to keep glutamate inside and the latter enriched cytosol. FCCP per se induced the greater release of l-[14C]glutamate in hypergravity as compared to control (4.8 ± 1.0% and 8.0 ± 1.0% of total label). Exocytotic release of l-[14C]glutamate evoked by depolarization was reduced down to zero after FCCP application under both conditions studied. Depolarization stimulated release of cytosolic l-[14C]glutamate from synaptosomes preliminary treated with FCCP was considerably increased from 27.0 ± 2.2% of total label in control to 35.0 ± 2.3% in hypergravity. Non-transportable inhibitor of glutamate transporter dl-threo-β-benzyloxyaspartate was found to significantly inhibit high-KCl and FCCP-stimulated release of l-[14C]glutamate, confirming the release by reversal of glutamate transporters. The enhancement of transporter-mediated release of glutamate in hypergravity was found to result at least partially from the inhibition of the activity of Na/K-ATPase in the plasma membrane of synaptosomes. We suggested that hypergravity-induced alteration in transporter-mediated release of glutamate indicated hypoxic injury of neurons.  相似文献   
412.
    
The determination of the range of radar is carried out according to statistical methods which are not always immediate. For this reason, a parametrical method is proposed which condenses the elements necessary for this calculation in the form of three abaci. Furthermore, a general formula condenses this result, and the formula is extended to the other transmission systems.  相似文献   
413.
414.
    
Computer-aided instruction (CAI) has not achieved widespread use, even though experimental results have been promising, because of a complex of technical, economic, and social factors. The problems these factors produce might be overcome if a major ?market success? could be achieved with CAI systems. One potentially high-volume market, having probably a lower resistance to profound innovation than other sectors of education, is the junior college. To achieve a market success which would catalyze public and private investment to sustain the growth and dissemination of CAI requires technical solutions in the areas of hardware, software, and courseware. Courseware is a term designating the applications programs for CAI systems and associated textual, audio-visual, and other materials of instruction. Two different approaches to the production of courseware and their underlying philosophies are discussed and contrasted. The extent to which these different models of courseware design and development might lead toward the goal of mass dissemination is highlighted.  相似文献   
415.
    
The Cassini-Huygens Cosmic Dust Analyzer (CDA) is intended to provide direct observations of dust grains with masses between 10−19 and 10−9 kg in interplanetary space and in the jovian and saturnian systems, to investigate their physical, chemical and dynamical properties as functions of the distances to the Sun, to Jupiter and to Saturn and its satellites and rings, to study their interaction with the saturnian rings, satellites and magnetosphere. Chemical composition of interplanetary meteoroids will be compared with asteroidal and cometary dust, as well as with Saturn dust, ejecta from rings and satellites. Ring and satellites phenomena which might be effects of meteoroid impacts will be compared with the interplanetary dust environment. Electrical charges of particulate matter in the magnetosphere and its consequences will be studied, e.g. the effects of the ambient plasma and the magnetic field on the trajectories of dust particles as well as fragmentation of particles due to electrostatic disruption.The investigation will be performed with an instrument that measures the mass, composition, electric charge, speed, and flight direction of individual dust particles. It is a highly reliable and versatile instrument with a mass sensitivity 106 times higher than that of the Pioneer 10 and 11 dust detectors which measured dust in the saturnian system. The Cosmic Dust Analyzer has significant inheritance from former space instrumentation developed for the VEGA, Giotto, Galileo, and Ulysses missions. It will reliably measure impacts from as low as 1 impact per month up to 104 impacts per second. The instrument weighs 17 kg and consumes 12 W, the integrated time-of-flight mass spectrometer has a mass resolution of up to 50. The nominal data transmission rate is 524 bits/s and varies between 50 and 4192 bps.This revised version was published online in July 2005 with a corrected cover date.  相似文献   
416.
    
In this chapter, I present a summary of observational tests of the basic picture of disk accretion. An emphasis is placed on tests relevant to black holes, but many of the fundamental results are drawn from studies of other classes of systems. Evidence is discussed for the basic structures of accretion flows. The cases of systems with and without accretion disks are discussed, as is the evidence that disks actually form. Also discussed are the hot spots where accretion streams impact the disks, and the boundary layers in the inner parts of systems where the accretors are not black holes. The nature of slow, large amplitude variability is discussed. It is shown that some of the key predictions of the classical thermal-viscous ionization instability model for producing outbursts are in excellent agreement with observational results. It is also show that there are systems whose outbursts are extremely difficult to explain without invoking variations in the rate of mass transfer from the donor star into the outer accretion disk, or tidally induced variations in the mass transfer rates. Finally, I briefly discuss recent quasar microlensing measurements which give truly independent constraints on the inner accretion geometry around black holes.  相似文献   
417.
    
The results of the interplanetary scintillation observations performed in the period of the maximum of solar activity from April 2013 to April 2014 on the BSA LPI radio telescope at the frequency 111MHz are presented. Fluctuations of the radio emission flux were recorded round the clock for all sources with a scintillating flux of more than 0.2 Jy falling in a strip of sky with a width of 50° over declinations corresponding to a 96-beam directional pattern of the radio telescope. The total number of sources observed during the day reaches 5000. The processing of the observational data was carried out on the assumption that a set of scintillating sources represents a homogeneous statistical ensemble. Daily two-dimensional maps of the distribution of the level of scintillations, whose analysis shows the strong nonstationarity and large-scale irregularity of the spatial distribution of solar wind parameters, were constructed. According to maps of the distribution of the level of scintillations averaged over monthly intervals, the global structure of the distribution of the solar wind was investigated in the period of the maximum of solar activity, which was found to be on the average close to spherically symmetric. The data show that on a spherically symmetric background an east–west asymmetry is observed, which indicates the presence of a large-scale structure of a spiral type in the solar wind.  相似文献   
418.
This paper presents the European Space Operations Centre's orbit determination and prediction systems for the ERS-1 mission. The routine operational orbit determination and prediction subsystem is discussed briefly, and statistics of the accuracy compared to the requirements are given. The precise orbit determination subsystem is then described, and the accuracy of its results are compared to those of the operational orbit system and to the D-PAF preliminary orbit solutions. Some geophysical results from the altimeter data, processed in these orbit determinations, are also presented. The ESOC/OAD ‘ERS-1 Orbit Report’ is introduced as a document providing this information on a monthly basis. Finally, this paper describes how the experience gained with the precise orbit determination will be exploited to further improve the accuracy of the routine system that will be used for ERS-2, and provides an estimate of this accuracy.  相似文献   
419.
We report initial measurements from the ULECA sensor of the Max-Planck-Institut/University of Maryland experiment on ISEE-1. ULECA is an electrostatic deflection — total energy sensor consisting of a collimator, deflection analyzer and an array of solid state detectors. The position of a given detector, which determines the energy per charge of an incident particle, together with the measured energy determine the particle's charge state. We find that a rich variety of phenomena are operative in the transthermal energy regime (10 keV/Q to 100 keV/Q) covered by ULECA. Specifically, we present observations of locally accelerated protons, alpha particles, and heavier ions in the magnetosheath and upstream of the Earth's bow shock. Preliminary analysis indicates that the behavior of these locally accelerated particles is most similar at the same energy per charge.  相似文献   
420.
McComas  D.J.  Bame  S.J.  Barker  P.  Feldman  W.C.  Phillips  J.L.  Riley  P.  Griffee  J.W. 《Space Science Reviews》1998,86(1-4):563-612
The Solar Wind Electron Proton Alpha Monitor (SWEPAM) experiment provides the bulk solar wind observations for the Advanced Composition Explorer (ACE). These observations provide the context for elemental and isotopic composition measurements made on ACE as well as allowing the direct examination of numerous solar wind phenomena such as coronal mass ejections, interplanetary shocks, and solar wind fine structure, with advanced, 3-D plasma instrumentation. They also provide an ideal data set for both heliospheric and magnetospheric multi-spacecraft studies where they can be used in conjunction with other, simultaneous observations from spacecraft such as Ulysses. The SWEPAM observations are made simultaneously with independent electron and ion instruments. In order to save costs for the ACE project, we recycled the flight spares from the joint NASA/ESA Ulysses mission. Both instruments have undergone selective refurbishment as well as modernization and modifications required to meet the ACE mission and spacecraft accommodation requirements. Both incorporate electrostatic analyzers whose fan-shaped fields of view sweep out all pertinent look directions as the spacecraft spins. Enhancements in the SWEPAM instruments from their original forms as Ulysses spare instruments include (1) a factor of 16 increase in the accumulation interval (and hence sensitivity) for high energy, halo electrons; (2) halving of the effective ion-detecting CEM spacing from ∼5° on Ulysses to ∼2.5° for ACE; and (3) the inclusion of a 20° conical swath of enhanced sensitivity coverage in order to measure suprathermal ions outside of the solar wind beam. New control electronics and programming provide for 64-s resolution of the full electron and ion distribution functions and cull out a subset of these observations for continuous real-time telemetry for space weather purposes. This revised version was published online in June 2006 with corrections to the Cover Date.  相似文献   
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