Preparation of the Biochip experiment on the EXPOSE-R2 mission outside the International Space Station

Biochips might be suited for planetary exploration. Indeed, they present great potential for the search for biomarkers – molecules that are the sign of past or present life in space – thanks to their size (miniaturized devices) and sensitivity. Their detection principle is based on the recognition of a target molecule by affinity receptors fixed on a solid surface. Consequently, one of the main concerns when developing such a system is the behavior of the biological receptors in a space environment. In this paper, we describe the preparation of an experiment planned to be part of the EXPOSE-R2 mission, which will be conducted on the EXPOSE-R facility, outside the International Space Station (ISS), in order to study the resistance of biochip models to space constraints (especially cosmic radiation and thermal cycling). This experiment overcomes the limits of ground tests which do not reproduce exactly the space parameters. Indeed, contrary to ground experiments where constraints are applied individually and in a limited time, the biochip models on the ISS will be exposed to cumulated constraints during several months. Finally, this ISS experiment is a necessary step towards planetary exploration as it will help assessing whether a biochip can be used for future exploration missions.     

Low latitude nighttime ionospheric vertical E × B drifts at African region

The nighttime vertical E × B drifts velocities of the F2-region were inferred from the hourly hmF2 values obtained from ionosonde data over an African equatorial station, Ilorin (8.50^oN, 4.68^oE; dip lat. 2.95^o) during period of low solar activity. For each season, the plasma drift Vz is characterized by an evening upward enhancement, then by a downward reversal at 1900 LT till around 0000 LT, except for June solstice. This was explained using the Rayleigh–Taylor (R-T) instability mechanism. The occasional drift differences in Vz obtained by inferred and direct measurement over Ilorin and Jicamarca, respectively are reflective of the importance of chemistry and divergent transport system due to both the E region electric and magnetic fields instead of simple motions. The pre-reversal enhancement (PRE) magnitude is higher during the equinoctial months than the solsticial months over Jicamarca, highest during December solstice and the equinoctial months over Ilorin, suggesting the dominance of higher E × B fountain during equinoxes at both stations. The lowest PRE magnitude was in June solstice. The appearance of post-noon peak in NmF2 around 1700 LT is highest during the equinoctial months and lowest during the solsticial period. A general sharp drop in NmF2 around 1800 LT is distinct immediately after sunset, lowest during June solstice and highest in March equinox. Our result suggests that between 0930 and 2100 LT, the general theory that vertical drifts obtained by digisonde measurements only match the E × B drift if the F layer is higher than 300 km is reliable, but does not hold for the nighttime period of 2200–0600 LT under condition of solar minima. Hence, the condition may not be sufficient for the representation of vertical plasma drift at nighttime during solar minima. This assertion may still be tentative, as more equatorial stations needed to be studied for better confirmation.     

Evaluation of upper body muscle activity during cardiopulmonary resuscitation performance in simulated microgravity

Performance of efficient single-person cardiopulmonary resuscitation (CPR) is vital to maintain cardiac and cerebral perfusion during the 2–4 min it takes for deployment of advanced life support during a space mission. The aim of the present study was to investigate potential differences in upper body muscle activity during CPR performance at terrestrial gravity (+1Gz) and in simulated microgravity (μG). Muscle activity of the triceps brachii, erector spinae, rectus abdominis and pectoralis major was measured via superficial electromyography in 20 healthy male volunteers. Four sets of 30 external chest compressions (ECCs) were performed on a mannequin. Microgravity was simulated using a body suspension device and harness; the Evetts–Russomano (ER) method was adopted for CPR performance in simulated microgravity. Heart rate and perceived exertion via Borg scores were also measured. While a significantly lower depth of ECCs was observed in simulated microgravity, compared with +1Gz, it was still within the target range of 40–50 mm. There was a 7.7% decrease of the mean (±SEM) ECC depth from 48 ± 0.3 mm at +1Gz, to 44.3 ± 0.5 mm during microgravity simulation (p < 0.001). No significant difference in number or rate of compressions was found between the two conditions. Heart rate displayed a significantly larger increase during CPR in simulated microgravity than at +1Gz, the former presenting a mean (±SEM) of 23.6 ± 2.91 bpm and the latter, 76.6 ± 3.8 bpm (p < 0.001). Borg scores were 70% higher post-microgravity compressions (17 ± 1) than post +1Gz compressions (10 ± 1) (p < 0.001). Intermuscular comparisons showed the triceps brachii to have significantly lower muscle activity than each of the other three tested muscles, in both +1Gz and microgravity. As shown by greater Borg scores and heart rate increases, CPR performance in simulated microgravity is more fatiguing than at +1Gz. Nevertheless, no significant difference in muscle activity between conditions was found, a result that is favourable for astronauts, given the inevitable muscular and cardiovascular deconditioning that occurs during space travel.     

Fuel consumption and collision avoidance strategy in multi-static orbit formations

This paper analyses the fuel consumption of interferometric radar missions employing small satellite formations like, e.g., Cross-track Pendulum, Cartwheel, CarPe, or Trinodal Pendulum. Individual analytic expressions are provided for each of the following contributions: separation from a simultaneously injected master satellite, formation set-up, orbit maintenance, formation maintenance, and distance maintenance. For this, a general system of equations is derived describing the relative motion of the small satellites in a co-rotating reference frame. The transformation into Keplerian elements is carried out. To evaluate fuel consumption, three master satellites are assumed in different orbital heights, which are typical for Earth observation missions. The size of the exemplarily analysed formations is defined by remote sensing aspects and their respective fuel requirements are estimated. Furthermore, a collision avoidance concept is introduced, which includes a formation separation and formation set-up after a desired time period.     

Interaction of mental and orthostatic stressors

We assessed hemodynamic responses induced by orthostatic and mental stressors, using passive head up tilt (HUT) and mental arithmetic (MA), respectively. The 15 healthy males underwent three protocols: (1) HUT alone, (2) MA in supine position and (3) MA+HUT, with sessions randomized and ≥2 weeks apart. In relation to baseline, HUT increased heart rate (HR) (+20.4±7.1 bpm; p<0.001), mean blood pressure (MBP) (+4.7±11.3 mmHg; p<0.05), diastolic blood pressure (DBP) (+6.1±11.6 mmHg; p<0.05) and total peripheral resistance (TPR) (+155±232 dyne*s/cm⁵; p<0.001) but decreased stroke volume (SV) (?33.1±13.4 ml; p<0.001) and cardiac output (CO) (?0.6±1.0 l/min; p<0.01). MA increased HR (+8.0±6.0 bpm; p<0.001), systolic blood pressure (SBP) (+9.0±7.7 mmHg; p<0.001), MBP (+10.0±6.5 mmHg; p<0.001), DBP (+9.5±7.2 mmHg; p<0.001) and CO (+0.6±0.8 l/min; p<0.01). MA+HUT increased HR (+28.8±8.4 bpm; p<0.001), SBP (+4.6±14.3 mmHg; p<0.05), MBP (+11.2±11.6 mmHg; p<0.001), DBP (+13.5±10.1 mmHg; p<0.001) and TPR (+160±199 dyne*s/cm⁵; p<0.001) but SV (?34.5±14.6 ml; p<0.001) decreased. Mental challenge during orthostatic challenge elicited greater increases in heart rate, despite similar reductions in stroke volume such as those during orthostatic stress alone. Overall, cardiac output decreases were less with combinations of mental and orthostatic challenges in comparison to orthostasis alone. This would suggest that carefully chosen mental stressors might affect orthostatic responses of people on standing up. Therefore, additional mental loading could be a useful countermeasure to alleviate the orthostatic responses of persons, particularly in those with histories of dizziness on standing up or on return to earth from the spaceflight environment of microgravity.     

Role of O.G. Gazenko in formation and advancement of space biology and medicine

Oleg G. Gazenko belongs to the noble cohort of pupils of well-known Russian physiologist L.A. Orbeli. He was one of the fathers of space biology and medicine, discipline in which he displayed his brilliant talents of experimenter and thinker. He was acknowledged for the investigations of spaceflight effects on living systems, the concept of medical operations system to support long-term piloted missions and implementation of biological researches that fostered the advance of space and gravitational biology. The analytical works of Oleg G. Gazenko are of imperishable significance for future researches to the benefit of space biomedicine.     

Identification of failures in a set of sensors of a spacecraft

A method to find and identify failures in a spacecraft’s set of sensitive elements that measure vector quantities of different nature is discussed.