Induction of high grade astrocytoma (HGA) by protons: molecular mechanisms and RBE considerations.

Protons of a specific energy, 55 MeV, have been found to induce primary high grade astrocytomas (HGA) in the Rhesus monkey (Macaca mulatta). Brain tumors of this type were not induced by protons of other energies (32-2,300 MeV). Induction of HGA has been identified in human patients who have had radiation therapy to the head. We believe that the induction of HGA in the monkey is a consequence of dose distribution, not some unique "toxic" property of protons. Comparison of the human experience with the monkey data indicates the RBE for induction of brain tumors to be about one. It is unlikely that protons cause an unusual change in oncogenic expression, as compared to conventional electromagnetic radiation.     

The fundamental parameters of the central stars of eight WR ring nebulae

We describe work that has recently been completed on deriving the fundamental parameters of eight WR stars through the photoionization modelling of their surrounding nebulae using non-LTE WR flux distributions. The resulting effective temperatures range from 57 000–71 000 K for the WN4-5 stars and <30 000–42 000 K for the WN6-8 stars. The derived stellar parameters are compared with those obtained from stellar emission line modelling. We find good agreement for the hot early WN stars, indicating that the non-LTE WR flux distributions have essentially the correct shape in the crucial far-UV region. We find lower temperatures for the four cooler late WN stars, particularly for the two WN6 stars. For the nebulae surrounding these stars, we find that the model flux distributions produce too much nebular ionization. We suggest that these discrepancies arise because of the lack of line-blanketing in the WR atmospheres. For the WO1 central star of G2.4+1.4, with strong nebular He II 4686 A emission, we derive a temperature of 105 000 K, somewhat less than previous estimates. The positions of our eight WR stars on the H-R diagram are compared with the evolutionary tracks of Maeder (1990) for solar metallicity. In common with previous workers, we find that our derived luminosities are too low, giving an initial mass range of 25–40 M, below that expected for the majority of WR stars.     

The complex Hα profile of the hypergiant HR 8752 during 1970–1992

The profiles of H observed during the 1970–1992 period in the binary hypergiant HR 8752 (G0 Ia) are presented. We distinguish five typical H profiles designated as A, B, C, D and E types according to the number of emission and absorption features. The profiles of H are complex and contain several emission and absorption components, with: –130 km/s in emission or absorption, –84 km/s in absorption, –49 km/s in emission and about +6 km/s in emission. All of them are rather stable in radial velocities except of the main absorption component in the P Cygni profile with –84 km/s. The frequency of appearance and the periods of duration of the occurrence of the components is discussed. The duration times range between about 3 to 10 months for various components. The red emission component E₂ is particularly interesting. Possible explanations of its origin are discussed.A long-term acceleration of the absorption component in the P Cygni profile is found; it can be interpreted as monotonous acceleration of the stellar wind.     

Wind asymmetries in massive stars

We are in the process of surveying the linear polarization in luminous, early-type stars. We here report on new observations of the B [e] stars S 18 and R 50, and of the Luminous Blue Variables HR Car, R 143, and HD 160529. Together with previously published data, these observations provide clear evidence for the presence of intrinsic polarization in 1 B[e] star (HD 34664) and in 5 LBVs ( Car, P Cyg, R 127, AG Car, and HR Car). The data indicate that anisotropic stellar winds are a common occurrence among massive stars in these particular evolutionary stages. For such stars, mass-loss rates estimated using the assumption of a spherical, homogeneous and stationary outflow may be in error.     

CRV investment offers safe return

The development and testing of a new emergency Crew Return Vehicle (CRV) prototype is discussed. The new CRV is being developed by NASA and ESA and is designed for use on the International Space Station as a supplement to the Soyuz ships of the Russians, which accommodate only three passengers. The new vehicle will provide a shirt-sleeve environment for up to six astronauts and will allow for emergency medical treatment to be provided.     

Effect of microgravity on Escherichia coli and MS-2 bacteriophage disinfection by iodinated resins

Experiments on chemical disinfection by iodinated resins were conducted on STS 50 (USML-1), which flew a 13 day mission during 1992. Fluid processing apparatus containing microorganisms and iodinated resins was assembled in either Manhattan, Kansas, or Boulder, Colorado, and loaded on-board the Space Shuttle for the mission. Pentaiodide resin was more effective than the triiodide resin against Escherichia coli. Both resins were more effective bactericides at unit gravity than microgravity because of cosedimentation of bacteria and iodinated resin beads. In bacteriophage experiments, the triiodide resin reduced the viable titer of MS-2 by nine logs. The few viable phage surviving chemical disinfection were associated with precipitant formation in the fluid processing apparatus.     

Radiative and hybrid cooling of infrared space telescopes

The designs of cold space telescopes, cryogenic and radiatively cooled, are similar in most elements and both benefit from orbits distant from the Earth. In particular such orbits allow the anti-sunward side of radiatively-cooled spacecraft to be used to provide large cooling radiators for the individual radiation shields. Designs incorporating these features have predictedT _tel near 20 K. The attainability of such temperatures is supported by limited practical experience (IRAS, COBE). Supplementary cooling systems (cryogens, mechanical coolers) can be advantageously combined with radiative cooling in hybrid designs to provide robustness against deterioration and yet lower temperatures for detectors, instruments, and even the whole telescope. The possibility of such major additional gains is illustrated by the Very Cold Telescope option under study forEdison, which should offerT _tel5 K for a little extra mechanical cooling capacity.     

Biological responses to space: results of the experiment "Exobiological Unit" of ERA on EURECA I.

Spores of different strains of Bacillus subtilis and the Escherichia coli plasmid pUC19 were exposed to selected conditions of space (space vacuum and/or defined wavebands and intensities of solar ultraviolet radiation) in the experiment ER 161 "Exobiological Unit" of the Exobiology Radiation Assembly (ERA) on board of the European Retrievable Carrier (EURECA). After the approximately 11 months lasting mission, their responses were studied in terms of survival, mutagenesis in the his (B. subtilis) or lac locus (pUC19), induction of DNA strand breaks, efficiency of DNA repair systems, and the role of external protective agents. The data were compared with those of a simultaneously running ground control experiment. The survival of spores treated with the vacuum of space, however shielded against solar radiation, is substantially increased, if they are exposed in multilayers and/or in the presence of glucose as protective, whereas all spores in "artificial meteorites", i.e. embedded in clays or simulated Martian soil, are killed. Vacuum treatment leads to an increase of mutation frequency in spores, but not in plasmid DNA. Extraterrestrial solar ultraviolet radiation is mutagenic, induces strand breaks in the DNA and reduces survival substantially; however, even at the highest fluences, i.e. 3 x 10(8) J m-2, a small but significant fraction of spores survives the insolation. Action spectroscopy confirms results of previous space experiments of a synergistic action of space vacuum and solar UV radiation with DNA being the critical target.     

Spatial orientation during locomotion [correction of locomation] following space flight

To investigate changes in spatial orientation ability and walking performance following space flight, 7 astronaut subjects were asked pre- and post-flight to perform a goal directed locomotion paradigm which consisted of walking a triangular path with and without vision. This new paradigm, involving inputs from different sensory systems, allows quantification of several critical parameters, like orientation performance, walking velocities and postural stability, in a natural walking task. The paper presented here mainly focusses on spatial orientation performance quantified by the errors in walking the previously seen path without vision. Errors in length and reaching the corners did not change significantly from pre- to post-flight, while absolute angular errors slightly increased post-flight. The significant decrease in walking velocity and a change in head-trunk coordination while walking around the corners of the path observed post-flight may suggest that during re-adaptation to gravity the mechanisms which are necessary to perform the task have to be re-accomplished.     

The effect of head-down tilt on brain potentials related to visual attention

To study the possible effect of simulated weightlessness on brain function state, the brain event-related potentials (ERPs) in a simple visual selective response task were compared between HDT and HUT in 9 normal subjects. The results were: The Target(T) and non-Target(NT) flash signals both induced significant slow positive potentials which were supposed to related to the attention state; the amplitude of the positive potentials in frontal regions decreased significantly especially for NT-ERPs during HDT comprared with that during HUT. The data reported provide new evidence indicating that more attention should be paid on the brain function study during space flight.