Induction of high grade astrocytoma (HGA) by protons: molecular mechanisms and RBE considerations.

Protons of a specific energy, 55 MeV, have been found to induce primary high grade astrocytomas (HGA) in the Rhesus monkey (Macaca mulatta). Brain tumors of this type were not induced by protons of other energies (32-2,300 MeV). Induction of HGA has been identified in human patients who have had radiation therapy to the head. We believe that the induction of HGA in the monkey is a consequence of dose distribution, not some unique "toxic" property of protons. Comparison of the human experience with the monkey data indicates the RBE for induction of brain tumors to be about one. It is unlikely that protons cause an unusual change in oncogenic expression, as compared to conventional electromagnetic radiation.     

Preservation of martian organic and environmental records: final report of the Mars biosignature working group

The Mars Science Laboratory (MSL) has an instrument package capable of making measurements of past and present environmental conditions. The data generated may tell us if Mars is, or ever was, able to support life. However, the knowledge of Mars' past history and the geological processes most likely to preserve a record of that history remain sparse and, in some instances, ambiguous. Physical, chemical, and geological processes relevant to biosignature preservation on Earth, especially under conditions early in its history when microbial life predominated, are also imperfectly known. Here, we present the report of a working group chartered by the Co-Chairs of NASA's MSL Project Science Group, John P. Grotzinger and Michael A. Meyer, to review and evaluate potential for biosignature formation and preservation on Mars. Orbital images confirm that layered rocks achieved kilometer-scale thicknesses in some regions of ancient Mars. Clearly, interplays of sedimentation and erosional processes govern present-day exposures, and our understanding of these processes is incomplete. MSL can document and evaluate patterns of stratigraphic development as well as the sources of layered materials and their subsequent diagenesis. It can also document other potential biosignature repositories such as hydrothermal environments. These capabilities offer an unprecedented opportunity to decipher key aspects of the environmental evolution of Mars' early surface and aspects of the diagenetic processes that have operated since that time. Considering the MSL instrument payload package, we identified the following classes of biosignatures as within the MSL detection window: organism morphologies (cells, body fossils, casts), biofabrics (including microbial mats), diagnostic organic molecules, isotopic signatures, evidence of biomineralization and bioalteration, spatial patterns in chemistry, and biogenic gases. Of these, biogenic organic molecules and biogenic atmospheric gases are considered the most definitive and most readily detectable by MSL.     

Regolith X-Ray Imaging Spectrometer (REXIS) Aboard the OSIRIS-REx Asteroid Sample Return Mission

The Regolith X-ray Imaging Spectrometer (REXIS) is the student collaboration experiment proposed and built by an MIT-Harvard team, launched aboard NASA’s OSIRIS-REx asteroid sample return mission. REXIS complements the scientific investigations of other OSIRIS-REx instruments by determining the relative abundances of key elements present on the asteroid’s surface by measuring the X-ray fluorescence spectrum (stimulated by the natural solar X-ray flux) over the range of energies 0.5 to 7 keV. REXIS consists of two components: a main imaging spectrometer with a coded aperture mask and a separate solar X-ray monitor to account for the Sun’s variability. In addition to element abundance ratios (relative to Si) pinpointing the asteroid’s most likely meteorite association, REXIS also maps elemental abundance variability across the asteroid’s surface using the asteroid’s rotation as well as the spacecraft’s orbital motion. Image reconstruction at the highest resolution is facilitated by the coded aperture mask. Through this operation, REXIS will be the first application of X-ray coded aperture imaging to planetary surface mapping, making this student-built instrument a pathfinder toward future planetary exploration. To date, 60 students at the undergraduate and graduate levels have been involved with the REXIS project, with the hands-on experience translating to a dozen Master’s and Ph.D. theses and other student publications.     

Error Probability for NCFSK with Linear FM Jamming

An expression is derived for the probability of error for a conventional binary, noncoherent, frequency-shift-key (NCFSK) communications system under the influence of bandpass Gaussian noise and a linear frequency-modulation jamming waveform. The resulting integral is expressed in terms of the well-known Q function, which depends upon average signal, noise, and jamming powers. The analytical procedures used can be applied to the analysis of the effects of other types of jamming.     

The THEMIS Array of Ground-based Observatories for the Study of Auroral Substorms

The NASA Time History of Events and Macroscale Interactions during Substorms (THEMIS) project is intended to investigate magnetospheric substorm phenomena, which are the manifestations of a basic instability of the magnetosphere and a dominant mechanism of plasma transport and explosive energy release. The major controversy in substorm science is the uncertainty as to whether the instability is initiated near the Earth, or in the more distant >20 Re magnetic tail. THEMIS will discriminate between the two possibilities by using five in-situ satellites and ground-based all-sky imagers and magnetometers, and inferring the propagation direction by timing the observation of the substorm initiation at multiple locations in the magnetosphere. An array of stations, consisting of 20 all-sky imagers (ASIs) and 30-plus magnetometers, has been developed and deployed in the North American continent, from Alaska to Labrador, for the broad coverage of the nightside magnetosphere. Each ground-based observatory (GBO) contains a white light imager that takes auroral images at a 3-second repetition rate (“cadence”) and a magnetometer that records the 3 axis variation of the magnetic field at 2 Hz frequency. The stations return compressed images, “thumbnails,” to two central databases: one located at UC Berkeley and the other at the University of Calgary, Canada. The full images are recorded at each station on hard drives, and these devices are physically returned to the two data centers for data copying. All data are made available for public use by scientists in “browse products,” accessible by using internet browsers or in the form of downloadable CDF data files (the “browse products” are described in detail in a later section). Twenty all-sky imager stations are installed and running at the time of this publication. An example of a substorm was observed on the 23rd of December 2006, and from the THEMIS GBO data, we found that the substorm onset brightening of the equatorward arc was a gradual process (>27 seconds), with minimal morphology changes until the arc breaks up. The breakup was timed to the nearest frame (<3 s) and located to the nearest latitude degree at about ±3^oE in longitude. The data also showed that a similar breakup occurred in Alaska ～10 minutes later, highlighting the need for an array to distinguish prime onset.     

Isotopic Signatures of Presolar Materials in Interplanetary Dust

Interplanetary dust particles collected in the stratosphere frequently exhibit enrichments in deuterium (D) and ¹⁵N relative to terrestrial materials. These effects are most likely due to the preservation of presolar interstellar materials. While the elevated D/H ratios probably resulted from mass fractionation during chemical reactions at very low < 100 K temperatures, the origin of the N isotopic anomalies remains unresolved. The bulk of the N-bearing material may have obtained its isotopic signatures from low temperature chemistry, but a nucleosynthetic origin is also possible. This revised version was published online in August 2006 with corrections to the Cover Date.