质量管理在中国香港的应用(英文)

香港工商企业的质量管理大部分都采用西方的质量管理概念。每当范畴扩展到建立人的优质思想和意识时，便遇到不少困难，基于上述问题，作者进行了一系列的研究，希望了解‘文化’与‘优质管理’之间的关系，并将中国的优良文化传统应用于现代质量管理之中。研究结果显示，‘管理哲学’是重要的一环，而我国的哲学极为丰富，作者借此文章，希望引起更多中国人在这方面的兴趣，从而进行更深入地研究和推广。     

Biodosimetry of heavyions by interphase chromosome painting

We report measurements of chromosomal aberrations in peripheral blood lymphocytes from cancer patients undergoingradiotherapy treatment. Patients with cervix or esophageal cancer were treated with 10 MV X-rays produced at a LINAC accelerator, or high-energy carbon ions produced at the HIMAC accelerator at the National Institute for Radiological Sciences (NIRS) in Chiba. Blood samples were obtained before, during, and after the radiation treatment. Chromosomes were prematurely condensed by incubation in calyculin A. Aberrations in chromosomes 2 and 4 were scored after fluorescence in situ hybridization with whole-chromosome probes. Pre-treatment samples were exposed in vitro to X-rays, individual dose-response curves for the induction of chromosomal aberrations were determined, and used as calibration curves to calculate the effective whole-body dose absorbed during the treatment. This calculated dose, based on the calibration curve relative to the induction of reciprocal exchanges, has a sharp increase after the first few fractions of the treatment, then saturates at high doses. Although carbon ions are 2–3 times more effective than X-rays in tumor sterilization, the effective dose was similar to that of X-ray treatment. However, the frequency of complex-type chromosomal exchanges was much higher for patients treated with carbon ions than X-ray.     

Solar flare forecasting model supported with artificial neural network techniques

Nowadays operational models for solar activity forecasting are still based on the statistical relationship between solar activity and solar magnetic field evolution. In order to set up this relationship, many parameters have been proposed to be the measures. Conventional measures are based on the sunspot group classification which provides limited information from sunspots. For this reason, new measures based on solar magnetic field observations are proposed and a solar flare forecasting model supported with an artificial neural network is introduced. This model is equivalent to a person with a long period of solar flare forecasting experience.     

Simultaneous measurement of multiple radiation-induced protein expression profiles using the Luminex(TM) system.

Space flight results in the exposure of astronauts to a mixed field of radiation composed of energetic particles of varying energies, and biological indicators of space radiation exposure provides a better understanding of the associated long-term health risks. Current methods of biodosimetry have employed the use of cytogenetic analysis for biodosimetry, and more recently the advent of technological progression has led to advanced research in the use of genomic and proteomic expression profiling to simultaneously assess biomarkers of radiation exposure. We describe here the technical advantages of the Luminex(TM) 100 system relative to traditional methods and its potential as a tool to simultaneously profile multiple proteins induced by ionizing radiation. The development of such a bioassay would provide more relevant post-translational dynamics of stress response and will impart important implications in the advancement of space and other radiation contact monitoring.     

Forecasting the future in space: Highlights from the TechCast Project

Space technology and activities have changed markedly from the early days of the space era and are continuing to develop rapidly. The TechCast Project—set up to pool the knowledge of experts in the scientific fields—includes space in its predictions. Here its president reports on its space forecasts for the 21st century. The importance of the shift towards the privatization of space is noted and the near-to-medium-term impossibility of interstellar travel conceded. Contact with ETI is deemed much more likely, however.     

Genomic instability and tumorigenic induction in immortalized human bronchial epithelial cells by heavy ions

Carcinogenesis is postulated to be a progressive multistage process characterized by an increase in genomic instability and clonal selection with each mutational event endowing a selective growth advantage. Genomic instability as manifested by the amplification of specific gene fragments is common among tumor and transformed cells. In the present study, immortalized human bronchial (BEP2D) cells were irradiated with graded doses of either 1GeV/nucleon ⁵⁶Fe ions or 150 keV/μm alpha particles. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Tumorigenic cells showed neither ras mutations nor deletion in the p16 tumor suppressor gene. In contrast, they harbored mutations in the p53 gene and over-expressed cyclin D1. Genomic instability among transformed cells at various stage of the carcinogenic process was examined based on frequencies of PALA resistance. Incidence of genomic instability was highest among established tumor cell lines relative to transformed, non-tumorigenic and control cell lines. Treatment of BEP2D cells with a 4 mM dose of the aminothiol WR-1065 significantly reduced their neoplastic transforming response to ⁵⁶Fe particles. This model provides an opportunity to study the cellular and molecular mechanisms involved in malignant transformation of human epithelial cells by heavy ions.     

The radiation continuum model of light and the Galilean invarianceof Maxwell's equations

The original basis for the Lorentz transformations, and thus special relativity, was the assumption that the observed velocity of interaction of light with matter represents a unique velocity of the electromagnetic wave. This arbitrary decision is not borne out by Maxwell's theories or by any test that might prove that EM energy actually travels in a continuum of velocities. The second postulate as stated by Einstein does not deserve the status of a postulate, as it is at once overly restrictive and ultimately phenomenological-the nature of c is based on experimental measurement rather than on analysis of first principles. The radiation continuum model's (RCM) modified second postulate, however, says nothing about the actual propagation of EM energy, but only of the relative speed with which it must interact with matter to be detected. Utilizing this modified light principle we obtain an intuitive Galilean form invariance for Maxwell's equations. RCM places no upper limit on attainable velocities, and allows for the possibility of communications between humans or particles at speeds far in excess of c. This precludes many of the compatibility problems between the highly successful quantum mechanics and relativity theory     

Force on a coil moving above a grid structure

The force on a coil moving with a high-speed parallel to a conducting grid consisting of parallel tubes is investigated. The coil performs a rebound motion or an oscillatory heave motion when pressed toward the grid by reactive on-board engines. The coil is approximated by two parallel wires moving parallel to the grid tubes. The corresponding electrodynamic problem is two dimensional and is solved by expansions in terms of Bessel functions. Expressions are derived for the lift and drag force as well as the heat generated in the tubes in the limit of strong skin effect. The dependence on the grid spacing is analysed in the approximation of no mutual inductance between the tubes. Two specific applications are a shunt deflecting the coil, and a funnel leading to multiple reflection. Finally, the varying magnetic flux threading the coil is considered and the thermal load of the coil is estimated.     

On the structure and dynamics of the thermosphere

Thermospheric temperature, composition and wind measurements from the Dynamics Explorer satellite (DE-2) are interpreted using a three dimensional, multiconstituent spectral model. The analysis accounts for tides driven by the absorbed solar radiation as well as energy and momentum coupling involving the magnetosphere and lower atmosphere. We discuss phenomena associated with the annual tide, polar circulation, magnetic storms and substorms.     

In situ measurements to determine if Phobos is layered

The complex system of linear features on Phobos—the inner moon of Mars—found by the Viking Orbiters in 1976, can be classified morphologically into three types according to their appearance as well as their geometrical distribution on the surface. One kind of grooves appears to form arcs of small circles normal to the Phobos-Mars direction. We propose that these grooves are the surface manifestation of layering within Phobos[4–6] which could have been formed when Phobos was a part of a much larger and geologically active parent planet.Here we suggest some measurements to observe whether Phobos has a layered structure or not. The suggestion contains remote sensing measurements (particularly determination of the magnetic field by magnetometer and by electron reflection method) by a spacecraft orbiting around Mars as well as surface measurements (active seismic reflection experiment) by a landing module on Phobos.