Identification of specific gravity sensitive signal transduction pathways in human A431 carcinoma cells.

Epidermal growth factor (EGF) activates a well characterized signal transduction cascade in human A431 epidermoid carcinoma cells. The influence of gravity on EGF-induced EGF-receptor clustering and early gene expression as well as on actin polymerization and actin organization have been investigated. Different signalling pathways induced by the agents TPA, forskolin and A23187 that activate gene expression were tested for sensitivity to gravity. EGF-induced c-fos and c-jun expression were decreased in microgravity. However, constitutive beta-2 microglobulin expression remained unaltered. Under simulated weightlessness conditions EGF- and TPA-induced c-fos expression was decreased, while forskolin- and A23187-induced c-fos expression was independent of the gravity conditions. These results suggest that gravity affects specific signalling pathways. Preliminary results indicate the EGF-induced EGF-receptor clustering remained unaltered irrespective of the gravity conditions. Furthermore, the relative filamentous actin content of steady state A431 cells was enhanced under microgravity conditions and actin filament organization was altered. Under simulated weightlessness actin filament organization in steady state cells as well as in EGF-treated cells was altered as compared to the 1 G reference experiment. Interestingly the microtubule and keratin organization in untreated cells showed no difference with the normal gravity samples. This indicates that gravity may affect specific components of the signal transduction circuitry.     

Some Comments on the Dynamics of Urban Structural Development

The suggestion is made that the aerospace industry examine the dynamics of urban structural development, that it identify the forces which act on the elements comprising the structure of the city, and that it describe the relationship between and the relative movements of those elements. By formulating such a general theory of urban structural development, urban political, social, and economic leadership may be given the means by which permanent remedies?including technological?may be devised and applied. This paper presents examples of such means and explains their application and effects.     

Identification and characteristics of source flares emitting 3-He or Fe enriched cosmic rays in the period September to December 1977

During the observation of solar cosmic rays on the Prognoz 6 and Helios 1 and 2 spacecrafts, several events with anomalous composition of accelerated particles (higher abundance of 3-He or Fe nuclei) occurred. We found seven such events from the period September to December 1977 for which data from the Prognoz 6 solar X-ray photometer are available. This material together with published optical and radio data from terrestrial observatories enabled us to identify more reliably the source flares and describe their characteristics. It turned out that the character of X-ray emission accompanying the emission of accelerated particles with anomalous composition shows no pronounced difference from other flares. No correlation has been found among the ratio 3-He/4-He and the angular distance between the field lines connected with the source flare and the place of observation. If a solar flare with anomalous ratio 3-He/4-He appears in a given active region, this region will probably produce other anomalous events.     

Physical characterization of the deep-space debris WT1190F: A testbed for advanced SSA techniques

We report on extensive ${\mathit{BVR}}_c{I}_c$ photometry and low-resolution ($\lambda /\mathrm{\Delta }\lambda ～250$) spectroscopy of the deep-space debris WT1190F, which impacted Earth offshore from Sri Lanka, on 2015 November 13. In spite of its likely artificial origin (as a relic of some past lunar mission), the case offered important points of discussion for its suggestive connection with the envisaged scenario for a (potentially far more dangerous) natural impactor, like an asteroid or a comet.Our observations indicate for WT1190F an absolute magnitude $R_c={32.45}_{\pm 0.31}$, with a flat dependence of reflectance on the phase angle, such as ${\mathit{dR}}_c/d?～{0.007}_{\pm 2}$?mag?deg^?1. The detected short-timescale variability suggests that the body was likely spinning with a period twice the nominal figure of $P_{\mathrm{flash}}={1.4547}_{\pm 0.0005}\mathrm{s}$, as from the observed lightcurve. In the ${\mathit{BVR}}_c{I}_c$ color domain, WT1190F closely resembled the Planck deep-space probe. This match, together with a depressed reflectance around 4000 and 8500 Å may be suggestive of a “grey” (aluminized) surface texture.The spinning pattern remained in place also along the object fiery entry in the atmosphere, a feature that may have partly shielded the body along its fireball phase perhaps leading a large fraction of its mass to survive intact, now lying underwater along a tight ($～1\times 80$?km) strip of sea, at a depth of 1500?m or less.Under the assumption of Lambertian scatter, an inferred size of ${216}_{\pm 30}/\sqrt{\alpha /0.1}$?cm is obtained for WT1190F. By accounting for non-gravitational dynamical perturbations, the Area-to-Mass ratio of the body was in the range $(0.006?\mathit{AMR}?0.011)$?m²?kg^?1.Both these figures resulted compatible with the two prevailing candidates to WT1190F’s identity, namely the Athena II Trans-Lunar Injection Stage of the Lunar Prospector mission, and the ascent stage of the Apollo 10 lunar module, callsign “Snoopy”. Both candidates have been analyzed in some detail here through accurate 3D CAD design mockup modelling and BRDF reflectance rendering to derive the inherent photometric properties to be compared with the observations.     

Mechanism of error propagation from the subdaily Universal Time model into the celestial pole offsets estimated by VLBI

Within the analysis of space geodetic observations, errors of the applied subdaily Earth rotation model can induce systematic effects in different estimated parameters. In this paper, we focus on the impact of the subdaily Universal Time (UT1) model on the celestial pole offsets (CPO) estimated from very long baseline interferometry (VLBI) observations. We provide a mechanism that describes the error propagation from the subdaily UT1 into the daily CPO.In typical 24-h VLBI sessions the observed quasars are well distributed over the sky. But the observations, if looked at from the Earth-fixed frame, are not homogeneously distributed. The amount of observations performed in different terrestrial directions shows an irregularity which can be roughly compared to the case where the observations are collected in only one Earth-fixed direction. This peculiarity leads to artefacts in VLBI solutions, producing a correlation between the subdaily variations in UT1 and the position of the celestial pole. As a result errors in diurnal terms of the subdaily UT1 model are partly compensated by the estimated CPO. We compute for each 24-h VLBI session from 1990 until 2011 the theoretical response of the CPO to an error in the subdaily UT1 by setting up a least-squares adjustment model and using as input the coordinates of the observed quasars and observation epochs. Then real observed response of the estimated CPO derived from the VLBI session solutions is compared to the predicted one. A very good agreement between the CPO values estimated from VLBI and the predicted values was achieved. The presented model of error propagation from the subdaily UT1 into the daily CPO allows to predict and explain the behaviour of CPO estimates of VLBI solutions computed with different subdaily Earth rotation models, what can be helpful for testing the accuracy of different subdaily tidal models.     

Adaptive control and stabilization of elastic spacecraft

This work treats the question of large angle rotational maneuver and stabilization of an elastic spacecraft (spacecraft-beam-tip body configuration). It is assumed that the parameters of the system are completely unknown. An adaptive control law is derived for the rotational maneuver of the spacecraft. Using the adaptive controller, asymptotically decoupled control of the pitch angle of the space vehicle is accomplished, however this maneuver causes elastic deformation of the beam connecting the orbiter and tip body. For the stabilization of the zero dynamics (flexible dynamics), a stabilizer is designed using elastic mode velocity feedback. In the closed-loop system including the adaptive controller and the stabilizer, reference pitch angle trajectory tracking and vibration suppression are accomplished. Simulation results are presented to show the maneuver capability of the control system     

Interplanetary origin of geomagnetic storms

Around solar maximum, the dominant interplanetary phenomena causing intense magnetic storms (Dst<−100 nT) are the interplanetary manifestations of fast coronal mass ejections (CMEs). Two interplanetary structures are important for the development of storms, involving intense southward IMFs: the sheath region just behind the forward shock, and the CME ejecta itself. Whereas the initial phase of a storm is caused by the increase in plasma ram pressure associated with the increase in density and speed at and behind the shock (accompanied by a sudden impulse [SI] at Earth), the storm main phase is due to southward IMFs. If the fields are southward in both of the sheath and solar ejecta, two-step main phase storms can result and the storm intensity can be higher. The storm recovery phase begins when the IMF turns less southward, with delays of ≈1–2 hours, and has typically a decay time of 10 hours. For CMEs involving clouds the intensity of the core magnetic field and the amplitude of the speed of the cloud seems to be related, with a tendency that clouds which move at higher speeds also posses higher core magnetic field strengths, thus both contributing to the development of intense storms since those two parameters are important factors in genering the solar wind-magnetosphere coupling via the reconnection process. During solar minimum, high speed streams from coronal holes dominate the interplanetary medium activity. The high-density, low-speed streams associated with the heliospheric current sheet (HCS) plasma impinging upon the Earth's magnetosphere cause positive Dst values (storm initial phases if followed by main phases). In the absence of shocks, SIs are infrequent during this phase of the solar cycle. High-field regions called Corotating Interaction Regions (CIRs) are mainly created by the fast stream (emanating from a coronal hole) interaction with the HCS plasma sheet. However, because the B_z component is typically highly fluctuating within the CIRs, the main phases of the resultant magnetic storms typically have highly irregular profiles and are weaker. Storm recovery phases during this phase of the solar cycle are also quite different in that they can last from many days to weeks. The southward magnetic field (B_s) component of Alfvén waves in the high speed stream proper cause intermittent reconnection, intermittent substorm activity, and sporadic injections of plasma sheet energy into the outer portion of the ring current, prolonging its final decay to quiet day values. This continuous auroral activity is called High Intensity Long Duration Continuous AE Activity (HILDCAAs). Possible interplanetary mechanisms for the creation of very intense magnetic storms are discussed. We examine the effects of a combination of a long-duration southward sheath magnetic field, followed by a magnetic cloud B_s event. We also consider the effects of interplanetary shock events on the sheath plasma. Examination of profiles of very intense storms from 1957 to the present indicate that double, and sometimes triple, IMF B_s events are important causes of such events. We also discuss evidence that magnetic clouds with very intense core magnetic fields tend to have large velocities, thus implying large amplitude interplanetary electric fields that can drive very intense storms. Finally, we argue that a combination of complex interplanetary structures, involving in rare occasions the interplanetary manifestations of subsequent CMEs, can lead to extremely intense storms. This revised version was published online in June 2006 with corrections to the Cover Date.     

Beagle 2: a proposed exobiology lander for ESA's 2003 Mars Express mission.

The aim of the proposed Beagle 2 small lander for ESA's 2003 Mars Express mission is to search for organic material on and below the surface of Mars and to study the inorganic chemistry and mineralogy of the landing site. The lander will have a total mass of 60kg including entry, descent, and landing system. Experiments will be deployed on the surface using a robotic arm. It will use a mechanical mole and grinder to obtain samples from below the surface, under rocks, and inside rocks. Sample analysis by a mass spectrometer will include isotopic analysis. An optical microscope, an X-ray spectrometer and a Mossbauer spectrometer will conduct in-situ rock studies.     

Fundamental (f) oscillations in a magnetically coupled solar interior-atmosphere system – An analytical approach

Solar fundamental (f) acoustic mode oscillations are investigated analytically in a magnetohydrodynamic (MHD) model. The model consists of three layers in planar geometry, representing the solar interior, the magnetic atmosphere, and a transitional layer sandwiched between them. Since we focus on the fundamental mode here, we assume the plasma is incompressible. A horizontal, canopy-like, magnetic field is introduced to the atmosphere, in which degenerated slow MHD waves can exist. The global (f-mode) oscillations can couple to local atmospheric Alfvén waves, resulting, e.g., in a frequency shift of the oscillations. The dispersion relation of the global oscillation mode is derived, and is solved analytically for the thin-transitional layer approximation and for the weak-field approximation. Analytical formulae are also provided for the frequency shifts due to the presence of a thin transitional layer and a weak atmospheric magnetic field. The analytical results generally indicate that, compared to the fundamental value ($\omega =\sqrt{\mathit{gk}}$), the mode frequency is reduced by the presence of an atmosphere by a few per cent. A thin transitional layer reduces the eigen-frequencies further by about an additional hundred microhertz. Finally, a weak atmospheric magnetic field can slightly, by a few percent, increase the frequency of the eigen-mode. Stronger magnetic fields, however, can increase the f-mode frequency by even up to ten per cent, which cannot be seen in observed data. The presence of a magnetic atmosphere in the three-layer model also introduces non-permitted propagation windows in the frequency spectrum; here, f-mode oscillations cannot exist with certain values of the harmonic degree. The eigen-frequencies can be sensitive to the background physical parameters, such as an atmospheric density scale-height or the rate of the plasma density drop at the photosphere. Such information, if ever observed with high-resolution instrumentation and inverted, could help to gain further insight into solar magnetic structures by means of solar magneto-seismology, and could provide further insight into the role of magnetism in solar oscillations.