Thyrotropin receptor and membrane interactions in FRTL-5 thyroid cell strain in microgravity

The aim of this work was to analyze the possible alteration of thyrotropin (TSH) receptors in microgravity, which could explain the absence of thyroid cell proliferation in the space environment. Several forms of the TSH receptor are localized on the plasma membrane associated with caveolae and lipid rafts. The TSH regulates the fluidity of the cell membrane and the presence of its receptors in microdomains that are rich in sphingomyelin and cholesterol. TSH also stimulates cyclic adenosine monophosphate (cAMP) accumulation and cell proliferation. Reported here are the results of an experiment in which the FRTL-5 thyroid cell line was exposed to microgravity during the Texus-44 mission (launched February 7, 2008, from Kiruna, Sweden). When the parabolic flight brought the sounding rocket to an altitude of 264?km, the culture media were injected with or without TSH in the different samples, and weightlessness prevailed on board for 6 minutes and 19 seconds. Control experiments were performed, in parallel, in an onboard 1g centrifuge and on the ground in Kiruna laboratory. Cell morphology and function were analyzed. Results show that in microgravity conditions the cells do not respond to TSH treatment and present an irregular shape with condensed chromatin, a modification of the cell membrane with shedding of the TSH receptor in the culture medium, and an increase of sphingomyelin-synthase and Bax proteins. It is possible that real microgravity induces a rearrangement of specific sections of the cell membrane, which act as platforms for molecular receptors, thus influencing thyroid cell function in astronauts during space missions.     

On the stabilization of ribose by silicate minerals

The RNA-world theory hypothesizes that early Earth life was based on the RNA molecule. However, the notion that ribose, the sugar in RNA, is unstable still casts a serious doubt over this theory. Recently, it has been found that the silicate-mediated formose reaction facilitates the stabilization of ribose. Using accurate quantum chemical calculations, we determined the relative stability of the silicate complexes of arabinose, lyxose, ribose, and xylose with the intent to determine which would form predominantly from a formose-like reaction. Five stereoisomers were investigated for each complex. The stereoisomers of 2:1 ribose-silicate are the more stable ones, to the extent that the least stable of these is even more stable than the most stable stereoisomer of the other 2:1 sugar-silicate complexes. Thus, thermodynamically, a formose-like reaction in the presence of silicate minerals should preferentially form the silicate complex of ribose over the silicate complex of arabinose, lyxose, and xylose.     

Deducing Electron Properties from Hard X-ray Observations

X-radiation from energetic electrons is the prime diagnostic of flare-accelerated electrons. The observed X-ray flux (and polarization state) is fundamentally a convolution of the cross-section for the hard X-ray emission process(es) in question with the electron distribution function, which is in turn a function of energy, direction, spatial location and time. To address the problems of particle propagation and acceleration one needs to infer as much information as possible on this electron distribution function, through a deconvolution of this fundamental relationship. This review presents recent progress toward this goal using spectroscopic, imaging and polarization measurements, primarily from the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI). Previous conclusions regarding the energy, angular (pitch angle) and spatial distributions of energetic electrons in solar flares are critically reviewed. We discuss the role and the observational evidence of several radiation processes: free-free electron-ion, free-free electron-electron, free-bound electron-ion, photoelectric absorption and Compton backscatter (albedo), using both spectroscopic and imaging techniques. This unprecedented quality of data allows for the first time inference of the angular distributions of the X-ray-emitting electrons and improved model-independent inference of electron energy spectra and emission measures of thermal plasma. Moreover, imaging spectroscopy has revealed hitherto unknown details of solar flare morphology and detailed spectroscopy of coronal, footpoint and extended sources in flaring regions. Additional attempts to measure hard X-ray polarization were not sufficient to put constraints on the degree of anisotropy of electrons, but point to the importance of obtaining good quality polarization data in the future.     

Heat transfer at various methods of thermal protection in the systems of power-driven gas turbine plants (GTP)

The scheme variants of implementing the thermal protection against heat flows being generated by the body of a high-temperature stationary gas turbine engine (GTE) are presented. The scheme of the experimental bench with a working section is given. Methodical approaches to the heat transfer calculation at different variants of forced and natural convection organization and under various operating conditions are described. The generalized results of the experiments carried out using a heat curtain being generated by porous injection are presented.     

Potential of salt-accumulating and salt-secreting halophytic plants for recycling sodium chloride in human urine in bioregenerative life support systems

This study addresses the possibility of growing different halophytic plants on mineralized human urine as a way to recycle NaCl from human wastes in a bioregenerative life support system (BLSS). Two halophytic plant species were studied: the salt-accumulating Salicornia europaea and the salt-secreting Limonium gmelinii. During the first two weeks, plants were grown on Knop’s solution, then an average daily amount of urine produced by one human, which had been preliminarily mineralized, was gradually added to the experimental solutions. Nutrient solutions simulating urine mineral composition were gradually added to control solutions. NaCl concentrations in the stock solutions added to the experimental and control solutions were 9 g/L in the first treatment and 20 g/L in the second treatment. The mineralized human urine showed some inhibitory effects on S. europaea and L. gmelinii. The biomass yield of experimental plants was lower than that of control ones. If calculated for the same time period (120 d) and area (1 m²), the amount of sodium chloride taken up by S. europaea plants would be 11.7 times larger than the amount taken up by L. gmelinii plants (486 g/m² vs. 41 g/m²). Thus, S. europaea is the better choice of halophyte for recycling sodium chloride from human wastes in BLSS.     

Seasonal variation of surface refractivity over Nigeria

The seasonal variation of surface refractivity over Nigeria was studied using two years in-situ meteorological data from eight locations over Nigeria. The result shows that the surface refractivity generally has higher value during rainy season than dry season at all location studied. The results also show that the value of surface refractivity increases from arid region in the north to the coastal area in south. The results also show that local meteorology plays a very important role in refractivity variation.     

Intelsat's next generation satellite for the Americas

In order to meet the growing demand for high performance C- and Ku-Band services in the Americas, INTELSAT contracted with Astrium in February 2000 to procure a high capacity communications spacecraft for its 310°E operational location. The spacecraft platform is based on Astrium's next generation platform, the Eurostar 3000. Several new technologies such as integrated Data Handling System, Plasma Propulsion System, etc. are integral features of this platform. The communication payload comprises 36 C-Band and 20 high power Ku-Band transponders. The beam coverages are tailored for the 310°E orbital location and are implemented using a hybrid shaped antenna design approach, where multiple C-Band coverages are generated from a single shaped reflector utilizing a pair of Tx/Rx feed horns for each coverage. The Ku-Band coverages are generated by the classical dual Gregorian shaped reflector antenna design approach. With a total dry mass on the order of 2650 kg and a separated launch mass of 5400 kg, the spacecraft is compatible with most of the available launch vehicles providing mission life of greater than 13 years. The paper will provide technical details of the spacecraft.     

DIRECT NUMERICAL SIMULATIONS OF MULTIPHASE FLOWS

INTRODUCTIONMultiphase and multifluid flows are commonin many natural and technologically importantprocesses. Rain,spray combustion,spray paint-ing,and boiling heat transfer are just a few ex-amples.While it is the overall,integral charac-teristics of such flows that are of most interest,the global behavior is determined to a large de-gree by the evolution of the smallestscales in theflow.The combustion of sprays,for example,depends on the size and the number density ofthe drops.Generally…     

Updated Review of Planetary Atmospheric Electricity

This paper reviews the progress achieved in planetary atmospheric electricity, with focus on lightning observations by present operational spacecraft, aiming to fill the hiatus from the latest review published by Desch et al. (Rep. Prog. Phys. 65:955–997, 2002). The information is organized according to solid surface bodies (Earth, Venus, Mars and Titan) and gaseous planets (Jupiter, Saturn, Uranus and Neptune), and each section presents the latest results from space-based and ground-based observations as well as laboratory experiments. Finally, we review planned future space missions to Earth and other planets that will address some of the existing gaps in our knowledge.