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521.
    
The aim of this work was to analyze the possible alteration of thyrotropin (TSH) receptors in microgravity, which could explain the absence of thyroid cell proliferation in the space environment. Several forms of the TSH receptor are localized on the plasma membrane associated with caveolae and lipid rafts. The TSH regulates the fluidity of the cell membrane and the presence of its receptors in microdomains that are rich in sphingomyelin and cholesterol. TSH also stimulates cyclic adenosine monophosphate (cAMP) accumulation and cell proliferation. Reported here are the results of an experiment in which the FRTL-5 thyroid cell line was exposed to microgravity during the Texus-44 mission (launched February 7, 2008, from Kiruna, Sweden). When the parabolic flight brought the sounding rocket to an altitude of 264?km, the culture media were injected with or without TSH in the different samples, and weightlessness prevailed on board for 6 minutes and 19 seconds. Control experiments were performed, in parallel, in an onboard 1g centrifuge and on the ground in Kiruna laboratory. Cell morphology and function were analyzed. Results show that in microgravity conditions the cells do not respond to TSH treatment and present an irregular shape with condensed chromatin, a modification of the cell membrane with shedding of the TSH receptor in the culture medium, and an increase of sphingomyelin-synthase and Bax proteins. It is possible that real microgravity induces a rearrangement of specific sections of the cell membrane, which act as platforms for molecular receptors, thus influencing thyroid cell function in astronauts during space missions.  相似文献   
522.
The results of modeling of ionospheric disturbances observed in the East Asian region during moderate storms are presented. The numerical model for ionosphere–plasmasphere coupling developed at the ISTP SB RAS is used to interpret the data of observations at ionospheric stations located in the longitudinal sector of 90–130°E at latitudes from auroral zone to equator. There is obtained a reasonable agreement between measurements and modeling results for winter and equinox. In the summer ionosphere, at the background of high ionization by the solar EUV radiation in the quiet geomagnetic period the meridional thermospheric wind strongly impacts the electron concentration in the middle and auroral ionosphere. The consistent calculations of the thermospheric wind permit to obtain the model results which are closer to summer observations. The actual information about the space-time variations of thermosphere and magnetosphere parameters should be taken into account during storms.  相似文献   
523.
Following an enthusiastic start in 1985, ESA's life support technology development programme was re-assessed in the mid- to late-1990s to reflect the strong reduction in European manned space ambitions which occurred at that time. Further development was essentially restricted to activities that could constitute ISS upgrades or enhancements, or support ISS utilisation/operations, together with a single, limited, activity (MELISSA) aimed at bioregenerative life support, in the continuing hope that there might be "life after Station". The paper describes the current status of these activities and summarises the main priorities for future development that were identified at the April 1999 Workshop on Advanced Life Support.  相似文献   
524.
The thermal resistance due to conductive heat transfer between two heat generating boxes mounted symmetrically on a thin mounting plate, one side of which is subjected to a constant heat flux and the opposite side is convectively cooled, is considered. The other two sides are maintained at constant temperature. A numerical solution for the temperature field is obtained and the heat transfer between the boxes is found by integrating between the critical heat flow lines. Various nondimensional parameters are identified and their influence on the thermal resistance is studied.  相似文献   
525.
    
A constant false alarm rate (CFAR) detection method which is based on a combination of median and morphological filters (MEMO) is proposed. The MEMO algorithm has robust performance with small CFAR loss, very good behavior at clutter edges and high detection performance in the case of closely spaced narrowband signals (targets). The proposed MEMO method is favourably compared with cell averaging (CA) and ordered statistics (OS) CFAR detectors. The Monte Carlo method is employed to analyze the MEMO-CFAR detector  相似文献   
526.
Observations of NGC 5194/95 with the Einstein HRI show a very strong nuclear X-ray source, surrounded by a diffuse flux, three point sources and the companion. The diffuse flux, which correlates well with the radio continuum, is likely to originate from the disk population with age 2·109 yrs. The large luminosity from the nuclear source, together with optical and radio observations, shows that it belongs to the low luminosity active nuclei, thus extending this class to luminosities less than 1040 erg/s.  相似文献   
527.
    
Over 60% clocks on board of the GPS satellites are working longer than their designed life. Therefore realizing their stabilities in a long time scales is essential to GPS navigation and positioning plus IGS time scale maintaining. IGS clock products from 2001 to 2010 are used to analyze the GPS satellite clock qualities such as frequency stabilities and clock noise level. We find out that for the clocks of Block IIA satellites the frequency stabilities and clock noise are 10 times worse than that of the Block IIR and IIR-M satellites. Moreover, the linear relationships between frequency stabilities and clock residuals have been deduced with an accuracy of better than 0.02 ns. Specially, it is noticed that the clock of the PRN27 is instable and the relationship between the frequency stability and residuals is at least a quadratic curve. Therefore, we suggested that GPS satellite clocks should be weighted by their quality levels in application, and the observations of the Block IIA should not be used for real-time positioning which required precision better than one meter.  相似文献   
528.
The results of experiments aboard spacecraft demonstrated the dependence of the pattern of biological processes on microgravity and on the ability of biological objects to adapt themselves to new environmental conditions. This is of fundamental importance for solving theoretical and practical problems of space biology, or elaborating the theory of organism's behavior in weightlessness, and for elucidating the global mechanisms of the action of microgravity on living systems.  相似文献   
529.
The designs of cold space telescopes, cryogenic and radiatively cooled, are similar in most elements and both benefit from orbits distant from the Earth. In particular such orbits allow the anti-sunward side of radiatively-cooled spacecraft to be used to provide large cooling radiators for the individual radiation shields. Designs incorporating these features have predictedT tel near 20 K. The attainability of such temperatures is supported by limited practical experience (IRAS, COBE). Supplementary cooling systems (cryogens, mechanical coolers) can be advantageously combined with radiative cooling in hybrid designs to provide robustness against deterioration and yet lower temperatures for detectors, instruments, and even the whole telescope. The possibility of such major additional gains is illustrated by the Very Cold Telescope option under study forEdison, which should offerT tel5 K for a little extra mechanical cooling capacity.  相似文献   
530.
    
Both heliophysics and planetary physics seek to understand the complex nature of the solar wind’s interaction with solar system obstacles like Earth’s magnetosphere, the ionospheres of Venus and Mars, and comets. Studies with this objective are frequently conducted with the help of single or multipoint in situ electromagnetic field and particle observations, guided by the predictions of both local and global numerical simulations, and placed in context by observations from far and extreme ultraviolet (FUV, EUV), hard X-ray, and energetic neutral atom imagers (ENA). Each proposed interaction mechanism (e.g., steady or transient magnetic reconnection, local or global magnetic reconnection, ion pick-up, or the Kelvin-Helmholtz instability) generates diagnostic plasma density structures. The significance of each mechanism to the overall interaction (as measured in terms of atmospheric/ionospheric loss at comets, Venus, and Mars or global magnetospheric/ionospheric convection at Earth) remains to be determined but can be evaluated on the basis of how often the density signatures that it generates are observed as a function of solar wind conditions. This paper reviews efforts to image the diagnostic plasma density structures in the soft (low energy, 0.1–2.0 keV) X-rays produced when high charge state solar wind ions exchange electrons with the exospheric neutrals surrounding solar system obstacles.The introduction notes that theory, local, and global simulations predict the characteristics of plasma boundaries such the bow shock and magnetopause (including location, density gradient, and motion) and regions such as the magnetosheath (including density and width) as a function of location, solar wind conditions, and the particular mechanism operating. In situ measurements confirm the existence of time- and spatial-dependent plasma density structures like the bow shock, magnetosheath, and magnetopause/ionopause at Venus, Mars, comets, and the Earth. However, in situ measurements rarely suffice to determine the global extent of these density structures or their global variation as a function of solar wind conditions, except in the form of empirical studies based on observations from many different times and solar wind conditions. Remote sensing observations provide global information about auroral ovals (FUV and hard X-ray), the terrestrial plasmasphere (EUV), and the terrestrial ring current (ENA). ENA instruments with low energy thresholds ((sim1~mbox{keV})) have recently been used to obtain important information concerning the magnetosheaths of Venus, Mars, and the Earth. Recent technological developments make these magnetosheaths valuable potential targets for high-cadence wide-field-of-view soft X-ray imagers.Section 2 describes proposed dayside interaction mechanisms, including reconnection, the Kelvin-Helmholtz instability, and other processes in greater detail with an emphasis on the plasma density structures that they generate. It focuses upon the questions that remain as yet unanswered, such as the significance of each proposed interaction mode, which can be determined from its occurrence pattern as a function of location and solar wind conditions. Section 3 outlines the physics underlying the charge exchange generation of soft X-rays. Section 4 lists the background sources (helium focusing cone, planetary, and cosmic) of soft X-rays from which the charge exchange emissions generated by solar wind exchange must be distinguished. With the help of simulations employing state-of-the-art magnetohydrodynamic models for the solar wind-magnetosphere interaction, models for Earth’s exosphere, and knowledge concerning these background emissions, Sect. 5 demonstrates that boundaries and regions such as the bow shock, magnetosheath, magnetopause, and cusps can readily be identified in images of charge exchange emissions. Section 6 reviews observations by (generally narrow) field of view (FOV) astrophysical telescopes that confirm the presence of these emissions at the intensities predicted by the simulations. Section 7 describes the design of a notional wide FOV “lobster-eye” telescope capable of imaging the global interactions and shows how it might be used to extract information concerning the global interaction of the solar wind with solar system obstacles. The conclusion outlines prospects for missions employing such wide FOV imagers.  相似文献   
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