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691.
692.
We have studied the induction of morphological transformation of Syrian hamster embryo cells by low doses of heavy ions with different linear energy transfer (LET), ranging from 13 to 400 keV/μm. Exponentially growing cells were irradiated with 12C or 28Si ion beams generated by the Heavy Ion Medical Accelerator in Chiba (HIMAC), inoculated to culture dishes, and transformed colonies were identified when the cells were densely stacked and showed a crisscross pattern. Over the LET range examined, the frequency of transformation induced by the heavy ions increased sharply at very low doses no greater than 5 cGy. The relative biological effectiveness (RBE) of the heavy ions relative to 250 kVp X-rays showed an initial increase with LET, reaching a maximum value of about 7 at 100 keV/μm, and then decreased with the further increase in LET. Thus, we confirmed that high LET heavy ions are significantly more effective than X-rays for the induction of in vitro cell transformation.  相似文献   
693.
In the slow solar wind, elements with (first) ionisation potential (FIP) between ∼10 eV and 22 eV are depleted by a factor of about 4 relative to their abundances in the Outer Convective Zone (OCZ), and helium (FIP = 24.5 eV) is further depleted by a factor of ∼1.8. This depletion, called the FIP effect, is much less pronounced in the high speed streams coming out of coronal holes. The systematics of element depletion suggests that the FIP effect is produced at a temperature ∼104 K and that it is controlled by the time of ionisation at the solar surface. At the boundary of the polar coronal holes, the transition from a strong to a weak FIP effect is relatively sharp and coincides with the change in coronal electron temperature, indicating a profound change in coronal as well as chromospheric properties at this boundary. This revised version was published online in June 2006 with corrections to the Cover Date.  相似文献   
694.
Collinear Earth–Moon libration points have emerged as locations with immediate applications. These libration point orbits are inherently unstable and must be maintained regularly which constrains operations and maneuver locations. Stationkeeping is challenging due to relatively short time scales for divergence, effects of large orbital eccentricity of the secondary body, and third-body perturbations. Using the Acceleration Reconnection and Turbulence and Electrodynamics of the Moon's Interaction with the Sun (ARTEMIS) mission orbit as a platform, the fundamental behavior of the trajectories is explored using Poincaré maps in the circular restricted three-body problem. Operational stationkeeping results obtained using the Optimal Continuation Strategy are presented and compared to orbit stability information generated from mode analysis based in dynamical systems theory.  相似文献   
695.
696.
It has been suggested that it is not simple double-strand breaks (dsb) but the non-reparable breaks which correlate well with the high biological effectiveness of high LET radiations for cell killing (Kelland et al., 1988; Radford, 1986). We have compared the effects of charged particles on cell death in 3 pairs of cell lines which are normal or defective in the repair of DNA dsbs. For the cell lines SL3-147, M10, and SX10 which are deficient in DNA dsb repair, RBE values were close to unity for cell killing induced by charged particles with linear energy transfer (LET) up to 200 keV/micrometer and were even smaller than unity for the LET region greater than 300 keV/micrometer. The inactivation cross section (ICS) increased with LET for all 3 pairs. The ICS of dsb repair deficient mutants was always larger than that of their parents for all the LET ranges, but with increasing LET the difference in ICS between the mutant and its parent became smaller. Since a small difference in ICS remained at LET of about 300 keV/micrometer, dsb repair may still take place at this high LET, even if its role is apparently small. These results suggest that the DNA repair system does not play a major role in protection against the attack of high LET radiations and that a main muse of cell death is non-reparable dsb which are produced at a higher yield compared with low LET radiations. No correlation was observed between DNA content or nuclear area and ICS.  相似文献   
697.
The OPAL monochromatic opacity tables are used to evaluate the impact of a non-standard chemical composition on solar models. A calibrated solar model with consistent diffusion including the effect of radiative forces and ionization on drift velocities is presented. It is shown that surface abundances are predicted to change slightly more than in traditional solar models where these refinements are not included. All elements included in the model settle at similar rates which is reflected in the relative variation in surface abundances ranging from 7.5% for calcium to 8.8% for argon. The structural difference between the consistent model and the traditional model is small, with a maximum effect of 0.3% for the isothermal sound speed at the base of the convection zone. The settling of CNO is only marginally affected. Opacity profiles have also been calculated with varying abundances for volatile elements, for which the abundances are poorly known, and other selected elements. It is shown that if one allows a 10% variation of these elements individually one can expect a peak Rosseland mean opacity variation of 3% for oxygen, a little less 2% for Si and Ne, and around 1% for Mg and S in the radiative zone. Other light metals and volatile elements have no significant impact on the opacity. This revised version was published online in June 2006 with corrections to the Cover Date.  相似文献   
698.
Classical bearings-only target-motion analysis (TMA) is restricted to sources with constant motion parameters (usually position and velocity). However, most interesting sources have maneuvering abilities, thus degrading the performance of classical TMA. In the passive sonar context a long-time source-observer encounter is realistic, so the source maneuver possibilities may be important in regard to the source and array baseline. This advocates for the consideration and modeling of the whole source trajectory including source maneuver uncertainty. With that aim, a convenient framework is the hidden Markov model (HMM). A basic idea consists of a two-levels discretization of the state-space. The probabilities of position transition are deduced from the probabilities of velocity transitions which, themselves, are directly related to the source maneuvering capability. The source state sequence estimation is achieved by means of classical dynamic programming (DP). This approach does not require any prior information relative to the source maneuvers. However, the probabilistic nature of the source trajectory confers a major role to the optimization of the observer maneuvers. This problem is then solved by using the general framework of the Markov decision process (MDP)  相似文献   
699.
Experiments and calculations on the trajectories of micron-sized spheres, suspended in a fluid that fills a dosed container which rotates about an axis perpendicular to g, relate to the planning and interpretation of clinostat experiments. For low Reynolds number motion, the orbits are nearly circular, the radius being inversely proportional to the rotation rate. The swimming direction of micro-organisms can be affected by light, gravity, vorticity etc. The trajectories of algae swimming in steadily rotating environments have been observed and compared with theoretical predictions for ideal gyrotactic micro-organisms, thus providing some insights into the mechanisms of gravitaxis, gyrotaxis and the behaviour of the cells.  相似文献   
700.
The PET instrument aboard the SAMPEX satellite has provided us with long-term intra-calibrated observations of geomagnetically trapped protons and deuterons in the inner zone, suitable for use in constraining the low-altitude portions of radiation belt models being developed as successors to AP-8. These observations have been summarized elsewhere (Looper et al., 1996). Here we report a detection of geomagnetically-trapped tritium at energies from 14 to 35 MeV/nuc below L = 1.2, at about 1/8 the flux of deuterium previously reported at that location and at similar energy per nucleon. We also demonstrate the utility of the SAMPEX/PET observations for measuring the east-west anisotropy in the trapped particle flux at low altitudes, which is due to displacement of particle gyrocenters from the position of observation in a region of strong flux gradients. This anisotropy is implicitly ignored in omnidirectional radiation-flux models, but it can be important to mission planners considering how to distribute shielding over the surface of oriented spacecraft in low Earth orbit.  相似文献   
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