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491.
492.
  总被引:1,自引:0,他引:1  
High-LET (linear energy transfer) charged particles induce DNA double-strand breaks (DSB) in a non-random fashion in mammalian cells. The clustering of DSB, probably determined by track structure as well as chromatin conformation, results in an excess of small- and intermediate-sized DNA fragments. DNA fragmentation in normal human fibroblasts (GM5758) was analyzed by pulsed-field gel electrophoresis after irradiation with photons (60Co) or 125 keV/micrometers nitrogen ions. Compared to conventional DSB analysis, i.e. assays only measuring the fraction of DNA smaller than a single threshold, the relative biological effectiveness (RBE) for DSB induction increased with 100%. Further, the size distribution of DNA fragments showed a significant dependence on radiation quality, with an excess of fragments up to 1 Mbp. Irradiation of naked genomic DNA without histone proteins increased the DSB yields 25 and 13 times for photons and nitrogen ions, respectively. The results suggest possible roles of both track structure and chromatin organization in the distribution of DNA double-strand breaks along the chromosome.  相似文献   
493.
We review the main activities carried out at Moussala peak (2925 m above sea level, 42°11′N, 23°35′E) station in Bulgaria, connected with cosmic ray investigations during the last five decades. Several important results obtained at the station are reported. The detector design and corresponding methodological studies of the presently operational devices are shown as well, precisely the Cherenkov light telescope, lead free neutron monitor and muon telescope. The scientific potential of the existing complex is discussed.  相似文献   
494.
The stability characteristics of dynamic dissipative compensators are investigated for multibody flexible space structures having nonlinear dynamics. The problem addressed is that of proving asymptotic stability of dynamic dissipative compensators. The stability proof uses the Lyapunov approach and exploits the inherent passivity of such systems. For such systems these compensators are shown to be robust to parametric uncertainties and unmodeled dynamics. The results are applicable to a large class of structures such as satellites with multiple payloads and space-based manipulators  相似文献   
495.
ICON Far UltraViolet (FUV) imager contributes to the ICON science objectives by providing remote sensing measurements of the daytime and nighttime atmosphere/ionosphere. During sunlit atmospheric conditions, ICON FUV images the limb altitude profile in the shortwave (SW) band at 135.6 nm and the longwave (LW) band at 157 nm perpendicular to the satellite motion to retrieve the atmospheric O/N2 ratio. In conditions of atmospheric darkness, ICON FUV measures the 135.6 nm recombination emission of \(\mathrm{O}^{+}\) ions used to compute the nighttime ionospheric altitude distribution. ICON Far UltraViolet (FUV) imager is a Czerny–Turner design Spectrographic Imager with two exit slits and corresponding back imager cameras that produce two independent images in separate wavelength bands on two detectors. All observations will be processed as limb altitude profiles. In addition, the ionospheric 135.6 nm data will be processed as longitude and latitude spatial maps to obtain images of ion distributions around regions of equatorial spread F. The ICON FUV optic axis is pointed 20 degrees below local horizontal and has a steering mirror that allows the field of view to be steered up to 30 degrees forward and aft, to keep the local magnetic meridian in the field of view. The detectors are micro channel plate (MCP) intensified FUV tubes with the phosphor fiber-optically coupled to Charge Coupled Devices (CCDs). The dual stack MCP-s amplify the photoelectron signals to overcome the CCD noise and the rapidly scanned frames are co-added to digitally create 12-second integrated images. Digital on-board signal processing is used to compensate for geometric distortion and satellite motion and to achieve data compression. The instrument was originally aligned in visible light by using a special grating and visible cameras. Final alignment, functional and environmental testing and calibration were performed in a large vacuum chamber with a UV source. The test and calibration program showed that ICON FUV meets its design requirements and is ready to be launched on the ICON spacecraft.  相似文献   
496.
This paper considers the axisymmetric transverse vibrations of aircraft nonuniform structural elements that are introduced by a thermal shock. Analytical solutions have been obtained and their numerical analysis has been performed.  相似文献   
497.
We study degeneracies in families of periodic solutions to the Beletsky equation which correspond to intersections of three manifolds of these solutions: the symmetric, the asymmetric, and the manifold belonging to one of the integrable cases, i.e., e = 0 or μ = 0. We obtain equations for these isolated solutions, which allow us to compute them with an arbitrary precision. It is shown that additional degeneracies take place at some of these solutions. The method we use is applicable to a wide class of nonlinear ordinary differential equations (ODEs) depending on parameters.  相似文献   
498.
    
The problem considered in this paper is the investigation of the properties of a mass-meter, i.e. the device for determining the mass of cosmonaut's body under zero-gravity conditions. The estimates of accuracy of mass measurement by this device are given, and the results of measuring the masses of cosmonauts' bodies on the Salyut 5 and 6 orbital stations are presented.  相似文献   
499.
    
When discussing problems related to medical service in space flight, particular attention should be given to the specific living conditions and changes associated with space flight. In disease and injury, surgery can be provided only after conservative therapy has failed. In this context gnotobiological chambers allowing surgery in aseptic conditions seem promising. A portable set of interchangeable surgical tools should be made of light-weight alloys that can be readily sterilized. Electroanalgesia in combination with auriculoacupuncture as well as peridureal anesthesia may be used as they allow normal operations in autonomous space flight conditions. Changes in the sympatho-adrenal and kallikrein-kinin systems, as well as water-electrolyte balance, should be taken into account in developing methods and means of medical service in critical situations. Special attention should be given to the prevention and treatment of brain edema in view of weightlessness-induced cephalad fluid shifts.  相似文献   
500.
    
For Space Transportation System (i.e. Space Shuttle) launched satellites destined for a Geosynchronous Earth Orbit (GEO), there is a need for cost-effective, versatile propulsion systems to provide the perigee burn, i.e. to boost the satellite from Low Earth Orbit (LEO) to Geosynchronous Transfer Orbit (GTO). Surveys of commercial spacecraft activities and future GEO satellite requirements indicate that a spacecraft propulsion system that will provide the perigee burn for a broad range of future commercial satellites would have an excellent market potential.Parametric studies to investigate and define attractive perigee-burn upper propulsion systems (i.e. an Upper Propulsion Stage, or a UPS) are presented. The feasibility and payload capacilities that could be provided by a UPS assembled from essentially off-the-shelf components and subsystems, and the benefits that could be achieved by using major subsystems specifically tailored for the application are presented. The results indicate that attractive UPS configurations can be defined using either off-the-shelf or optimized major subsystems.  相似文献   
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