Delta-electron emission in fast heavy ion atom collisions.

Biological damages such as mutations, chromosomal aberrations etc. are a consequence of biochemical changes mostly in the DNA. With ionizing radiation, these chemical changes are due to primary ionization events and secondary ionization effects caused by the primarily produced electrons. Differences in the biological response of densely ionizing radiation, like heavy charged particles, in comparison to sparsely ionizing radiation, such as X- or gamma-rays, are mainly due to the differences in the production of the so called delta-electrons. Therefore, the emission process of electrons i.e. the cross section for the primary ionization event as well as the energy and angular distribution of the emitted electrons should be understood in detail. The delta-electron emission processes occuring in fast heavy ion atom collisions are explained qualitatively. The different spectral structures of electron emission arising from either the target or the projectile are explained in terms of simple models of the kinetics of momentum transfer induced by the COULOMB forces. In collisions of very heavy ions with matter, high nuclear COULOMB forces are created. These forces lead to a strong polarization of the electronic states of the participated electrons. The effects of this polarization are discussed.     

Extreme starburst or central activity in X-ray luminous IRAS galaxies

ROSAT All Sky Survey observations of IRAS galaxies have revealed up to now a number of 10 optically non-Seyfert galaxies with X-ray (0.1–2.4) luminosities up to a few 10⁴³erg · s⁻¹ (Boller et al. 1992). The sources are brighter than previous detection limits of a few 10⁴¹erg · s⁻¹ as found by Stocke et al. (1991) or Green, Anderson and Ward (1992) for Einstein sources. The optical classification is based on follow-up observations which indicate clearly the non-Seyfert (LINER and HII region-like galaxies) nature. Our investigations reveal that galaxies classified as non-Seyferts on the basis of optical spectroscopy may reach exceptionally high X-ray luminosities which are similar to that of Seyfert galaxies. On the basis of the present observational material we suppose a hidden low luminosity AGN in the centre of these objects as the source of energy production. The objects are of interest when evaluating starburst versus central activity.     

Deoxyribonucleoprotein structure and radiation injury: cellular radiosensitivity is determined by LET infinity -dependent DNA damage in hydrated deoxyribonucleoproteins and the extent of its repair.

For decades, theories of cellular radiosensitivity relied upon the initial patterns of energy deposition to explain radiation lethality. Such theories are unsound: cellular (DNA) repair also underlies cellular radiosensitivity. For the charged particles encountered in deep space, both the types of DNA damage caused in cellular deoxyribonucleoproteins and the efficacies of their repair are dependent on linear energy transfer (LET infinity), and repair efficiency is also influenced by cell and tissue type, i.e., the actual recovery processes involved. Therefore, quality factors derived from radiation quality alone are inadequate parameters for assessing the radiation risks of space flight. Until recently, OH radicals formed in bulk nuclear water were believed to be the major causes of DNA damage that results in cell death, especially for sparsely ionizing radiations. That hypothesis has now been challenged, if not refuted. Lethal genomic DNA damage is determined mainly by energy deposition in deoxyribonucleoproteins, and their hydration shells, and charge (energy) transfer processes within those structures.     

Development of countermeasures for medical problems encountered in space flight.

By the turn of this century, long-duration space missions, either in low Earth orbit or for got early planetary missions, will become commonplace. From the physiological standpoint, exposure to the weightless environment results in changes in body function, some of which are adaptive in nature and some of which can be life threatening. Important issues such as environmental health, radiation protection, physical deconditioning, and bone and muscle loss are of concern to life scientists and mission designers. Physical conditioning techniques such as exercise are not sufficient to protect future space travellers. A review of past experience with piloted missions has shown that gradual breakdown in bone and muscle tissue, together with fluid losses, despite a vigorous exercise regimen can ultimately lead to increased evidence of renal stones, musculoskeletal injuries, and bone fractures. Biological effects of radiation can, over long periods of time increase the risk of cancer development. Today, a vigorous program of study on the means to provide a complex exercise regimen to the antigravity muscles and skeleton is under study. Additional evaluation of artificial gravity as a mechanism to counteract bone and muscle deconditioning and cardiovascular asthenia is under study. New radiation methods are being developed. This paper will deal with the results of these studies.     

一种新的基于波形处理的数字式自动测距系统

提出了一种新的基于波形处理的全数字式自动测距系统的设计，介绍了该系统采用的信息匹配滤波器、波形采集和数据传输、波形分析等技术。给出了该系统的实验、雷达外场校飞试验和靶场精度校飞试验的结果。试验结果表明，该系统的原理正确，功能及扩展能力强，性能可靠。     

Results from the Energetic Gamma-Ray Experiment Telescope (EGRET) on the Compton Observatory

The Energetic Gamma-Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory covers the high energy gamma ray energy range, approximately 30 MeV to 30 GeV, with a sensitivity considerably greater than earlier high energy gamma-ray satellites. Thus far, 4 pulsars have been detected and their properties measured, including in 3 cases the energy spectrum as a function of phase. The details of the galactic plane are being mapped and a spectra of the center region has been obtained in good agreement with that expected from cosmic ray interactions. The Magellanic clouds have been examined with the Large Magellanic Cloud having been detected at a level consistent with it having a cosmic ray density compatible with quasi-stable equilibrium. Sixteen Active Galactic Nuclei (AGN's) have been seen thus far with a high degree of certainty including 12 quasars and 4 BL Lac objects, but no Seyferts. Time variation has been detected in some of these AGN's.     

Radiation protection against early and late effects of ionizing irradiation by the prostaglandin inhibitor indomethacin.

Protective effects of indomethacin, a prototype prostaglandin-inhibiting agent, against early and late sequelae of radiation injury (after X-rays or gamma rays) in mice were investigated. The following tissues or organs were examined: hematopoietic tissue, esophagus, jejunum, colon, lung, hair follicles, and tissues involved in the development of radiation-induced leg contractures. In addition, the effect of indomethacin was tested against radiation-induced carcinogenesis. In all experiments, the radiation was delivered as a single dose. Indomethacin led to significant protection of hematopoietic tissue, by a factor of 1.3. There was also some protection against radiation-induced pneumonitis and against radiation-induced carcinogenesis (protection factor of 1.2). The other tissues tested showed no change in their radioresponse after being treated with indomethacin. Thus, indomethacin can act as a radioprotective agent against both early and late sequelae of radiation, but its effect is dependent on the tissue tested. This protection is smaller than that observed with WR-2721. However, indomethacin combined with WR-2721 produced a radioprotective effect greater than the radioprotection achieved by individual treatments.     

Improved motion-mode estimation

Hybrid trackers incorporating a non-Markov modal model have been proposed. However, these algorithms use a restricted measurement set to identify the modal state. It is shown here that a renewal process model, along with broader measurement fusion, enhances modal classification in such estimators.     

Heavy-ion effects on cellular and subcellular systems: inactivation, chromosome aberrations and strand breaks induced by iron and nickel ions.

A broad spectrum of particles and energies has been used in the last years to study the influence of the radiation quality i.e. of the physical parameters of the particle beam on the biological effectiveness ?2?12?. In these measurements a common structure of the functional dependence of the induction probability per particle (cross section) from the linear energy transfer is observed for different biological endpoints. Because of the relevance for space research, we present in this report our data from experiments with iron and nickel particles, in particular. Our experiments were designed to investigate the relationship between the inactivation and chromosome aberration in mammalian cells and the induction of single and double strand breaks in SV40 DNA in respect to the parameters of the track formation like LET and particle energy.