CRV investment offers safe return

The development and testing of a new emergency Crew Return Vehicle (CRV) prototype is discussed. The new CRV is being developed by NASA and ESA and is designed for use on the International Space Station as a supplement to the Soyuz ships of the Russians, which accommodate only three passengers. The new vehicle will provide a shirt-sleeve environment for up to six astronauts and will allow for emergency medical treatment to be provided.     

Biological responses to space: results of the experiment "Exobiological Unit" of ERA on EURECA I.

Spores of different strains of Bacillus subtilis and the Escherichia coli plasmid pUC19 were exposed to selected conditions of space (space vacuum and/or defined wavebands and intensities of solar ultraviolet radiation) in the experiment ER 161 "Exobiological Unit" of the Exobiology Radiation Assembly (ERA) on board of the European Retrievable Carrier (EURECA). After the approximately 11 months lasting mission, their responses were studied in terms of survival, mutagenesis in the his (B. subtilis) or lac locus (pUC19), induction of DNA strand breaks, efficiency of DNA repair systems, and the role of external protective agents. The data were compared with those of a simultaneously running ground control experiment. The survival of spores treated with the vacuum of space, however shielded against solar radiation, is substantially increased, if they are exposed in multilayers and/or in the presence of glucose as protective, whereas all spores in "artificial meteorites", i.e. embedded in clays or simulated Martian soil, are killed. Vacuum treatment leads to an increase of mutation frequency in spores, but not in plasmid DNA. Extraterrestrial solar ultraviolet radiation is mutagenic, induces strand breaks in the DNA and reduces survival substantially; however, even at the highest fluences, i.e. 3 x 10(8) J m-2, a small but significant fraction of spores survives the insolation. Action spectroscopy confirms results of previous space experiments of a synergistic action of space vacuum and solar UV radiation with DNA being the critical target.     

Biochemical constraints for survival under Martian conditions.

A wide variety of terrestrial organisms, the so-called "anhydrobiotes," has learned to survive in a state of extreme dehydration in dry environments. Strategies for survival include the accumulation of certain polyols and nonreducing saccharides, which help to prevent damage to membranes and proteins, but at low water partial pressure DNA is also progressively damaged by various lesions, including strand breaks and cross-linking to proteins. These lesions, if they are not too numerous, can be repaired before the first replication step after rehydration, but long-term exposure to dry conditions finally diminishes the chances of survival as these lesions accumulate. If an organism has no chance to repair the accumulated DNA damage during intermittent periods of active life, survival will not exceed a few decades. The restriction of survival by dryness-induced DNA lesions is corroborated by new data on conidia of Aspergillus and the free plasmid pBR 322. Our results will be discussed with respect to the chance of finding dormant life or biochemical fossils on the surface of Mars.     

Human productivity in space and systems costs

Human productivity during assembly operations in-orbit is dependent on limits set by fatigue, metabolic rates, learning, and assembly techniques. In order to quantify these effects, tests were conducted in the NASA MSFC Neutral Buoyancy Simulator, in the NASA KC-135 in parabolic flight, and in space with the EASE program during the Shuttle Atlantis mission 61-B. A separate program attempted to relate productivity to system costs. Because of the surprisingly high productivity which had been demonstrated in orbit, it was shown that assembly operations would have only a small effect on system costs at the present level of launch costs. The results of these continuing studies have been reported in a recent paper(1). They will be briefly summarized here and the results updated to include additional cost elements and to examine the effects of reductions in transportation costs, resulting from advances in technology and from increased demand, on system costs. It is shown that, as launch costs are reduced, the assembly costs could become an increasingly important component of the total system costs.     

The effect of head-down tilt on brain potentials related to visual attention

To study the possible effect of simulated weightlessness on brain function state, the brain event-related potentials (ERPs) in a simple visual selective response task were compared between HDT and HUT in 9 normal subjects. The results were: The Target(T) and non-Target(NT) flash signals both induced significant slow positive potentials which were supposed to related to the attention state; the amplitude of the positive potentials in frontal regions decreased significantly especially for NT-ERPs during HDT comprared with that during HUT. The data reported provide new evidence indicating that more attention should be paid on the brain function study during space flight.     

Life in space may help life on Earth

Teams of chronobiologists from the U.S., Russia, and Japan are working toward a remote computerized health care system which, once tested in space, may change how doctors diagnose and treat cardiovascular diseases, including hypertension and conditions predisposing stroke. The system is based on ongoing research indicating that swings in blood pressure charted over a span of 24 hr or longer, rather than a single systolic and diastolic reading, can reveal a new major risk factor for heart disease.     

Analysis of Multimodal Systems

The estimation of a multimodal linear system whose mode-to-mode transitions are described by a finite-state Markov chain is described. The problem has application in studying separation standards in an air traffic control environment. An optimal solution is formulated which is computationally infeasible. A suboptimal estimator is then derived which closely approximates the optimal estimator. An example is presented to illustrate the technique.     

Probing the era of galaxy formation via TeV gamma ray absorption by the near infrared extragalactic background

We present models of the extragalactic background light (EBL) based on several scenarios of galaxy formation and evolution. We have treated galaxy formation with the Press-Schecter approximation for both cold dark matter (CDM) and cold+hot dark matter (CHDM) models, representing a moderate (z _f 3) and a late (z _f 1) era of galaxy formation respectively. Galaxy evolution has been treated by considering a variety of stellar types, different initial mass functions and star formation histories, and with an accounting of dust absorption and emission. We find that the dominant factor influencing the EBL is the epoch of galaxy formation. A recently proposed method for observing the EBL utilizing the absorption of 0.1 to 10 TeV gamma-rays from active galactic nuclei (AGN) is shown to be capable of discriminating between different galaxy formation epochs. The one AGN viewed in TeV light, Mrk 421, does show some evidence for a cutoff above 3 TeV; based on the EBL models presented here, we suggest that this is due to extinction in the source. The large absorption predicted at energies > 200 GeV for sources at z > 0.5 indicates that observations of TeV gamma-ray bursts (GRB) would constrain or eliminate models in which the GRB sources lie at cosmological distances.Now at University of Chicago, Dept. of Astronomy & Astrophysics.     

Aerosols on the Giant Planets and Titan

On the giant planets and Titan, like on the terrestrial planets, aerosols play an important part in the physico-chemistry of the upper atmosphere (P ≤ 0.5 bar). Above all, aerosols significantly affect radiative transfer processes, mainly through light scattering, thus influencing the atmospheric energy budget and dynamics. Because there is usually significant coupling between atmospheric circulation and haze production, aerosols may constitute useful tracers of atmospheric dynamics.More generally, since their production is directly linked to some kind of energy deposition, their study may also provide clues to external sources of energy as well as their variability. Finally, aerosols indirectly influence other processes such as cloud formation and disequilibrium chemistry, by acting either as condensation nuclei or as reaction sites for surface chemistry. Here, I present a review of observational and modeling results based on remote sensing data, and also some insights derived from laboratory simulations. Despite our knowledge of the effects of aerosols in outer planetary atmospheres, however, relatively little is understood about the pathways which produce them, either endogenously (as end-products of gas-phase photochemical or shock reactions) or exogenously (as residues of meteroid ablation).