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661.
  总被引:1,自引:0,他引:1  
High-LET (linear energy transfer) charged particles induce DNA double-strand breaks (DSB) in a non-random fashion in mammalian cells. The clustering of DSB, probably determined by track structure as well as chromatin conformation, results in an excess of small- and intermediate-sized DNA fragments. DNA fragmentation in normal human fibroblasts (GM5758) was analyzed by pulsed-field gel electrophoresis after irradiation with photons (60Co) or 125 keV/micrometers nitrogen ions. Compared to conventional DSB analysis, i.e. assays only measuring the fraction of DNA smaller than a single threshold, the relative biological effectiveness (RBE) for DSB induction increased with 100%. Further, the size distribution of DNA fragments showed a significant dependence on radiation quality, with an excess of fragments up to 1 Mbp. Irradiation of naked genomic DNA without histone proteins increased the DSB yields 25 and 13 times for photons and nitrogen ions, respectively. The results suggest possible roles of both track structure and chromatin organization in the distribution of DNA double-strand breaks along the chromosome.  相似文献   
662.
We review the main activities carried out at Moussala peak (2925 m above sea level, 42°11′N, 23°35′E) station in Bulgaria, connected with cosmic ray investigations during the last five decades. Several important results obtained at the station are reported. The detector design and corresponding methodological studies of the presently operational devices are shown as well, precisely the Cherenkov light telescope, lead free neutron monitor and muon telescope. The scientific potential of the existing complex is discussed.  相似文献   
663.
ICON Far UltraViolet (FUV) imager contributes to the ICON science objectives by providing remote sensing measurements of the daytime and nighttime atmosphere/ionosphere. During sunlit atmospheric conditions, ICON FUV images the limb altitude profile in the shortwave (SW) band at 135.6 nm and the longwave (LW) band at 157 nm perpendicular to the satellite motion to retrieve the atmospheric O/N2 ratio. In conditions of atmospheric darkness, ICON FUV measures the 135.6 nm recombination emission of \(\mathrm{O}^{+}\) ions used to compute the nighttime ionospheric altitude distribution. ICON Far UltraViolet (FUV) imager is a Czerny–Turner design Spectrographic Imager with two exit slits and corresponding back imager cameras that produce two independent images in separate wavelength bands on two detectors. All observations will be processed as limb altitude profiles. In addition, the ionospheric 135.6 nm data will be processed as longitude and latitude spatial maps to obtain images of ion distributions around regions of equatorial spread F. The ICON FUV optic axis is pointed 20 degrees below local horizontal and has a steering mirror that allows the field of view to be steered up to 30 degrees forward and aft, to keep the local magnetic meridian in the field of view. The detectors are micro channel plate (MCP) intensified FUV tubes with the phosphor fiber-optically coupled to Charge Coupled Devices (CCDs). The dual stack MCP-s amplify the photoelectron signals to overcome the CCD noise and the rapidly scanned frames are co-added to digitally create 12-second integrated images. Digital on-board signal processing is used to compensate for geometric distortion and satellite motion and to achieve data compression. The instrument was originally aligned in visible light by using a special grating and visible cameras. Final alignment, functional and environmental testing and calibration were performed in a large vacuum chamber with a UV source. The test and calibration program showed that ICON FUV meets its design requirements and is ready to be launched on the ICON spacecraft.  相似文献   
664.
Mass-independent fractionation (MIF) of sulfur isotopes has been reported in sediments of Archean and Early Proterozoic Age (> 2.3 Ga) but not in younger rocks. The only fractionation mechanism that is consistent with the data on all four sulfur isotopes involves atmospheric photochemical reactions such as SO2 photolysis. We have used a one-dimensional photochemical model to investigate how the isotopic fractionation produced during SO2 photolysis would have been transferred to other gaseous and particulate sulfur-bearing species in both low-O2 and high-O2 atmospheres. We show that in atmospheres with O2 concentrations < 10(-5) times the present atmospheric level (PAL), sulfur would have been removed from the atmosphere in a variety of different oxidation states, each of which would have had its own distinct isotopic signature. By contrast, in atmospheres with O2 concentrations > or = 10(-5) PAL, all sulfur-bearing species would have passed through the oceanic sulfate reservoir before being incorporated into sediments, so any signature of MIF would have been lost. We conclude that the atmospheric O2 concentration must have been < 10(-5) PAL prior to 2.3 Ga.  相似文献   
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667.
    
J D Fernstrom 《Acta Astronautica》1981,8(9-10):1035-1042
The rates of synthesis by brain neurons of the neurotransmitters serotonin, acetylcholine, and the catecholamines depend on the brain levels of the respective precursor molecules. Brain levels of each precursor are influenced by their blood concentration, and for the amino acid precursors, by the blood levels of other amino acids as well. Since diet readily alters blood concentrations of each of these precursors, it thereby also influences the brain formation of their neurotransmitter products.  相似文献   
668.
    
Human spatial orientation and oculomotor control are under multimodal influence. It is not possible in the normal animal to stimulate differentially the vestibular receptors without activating other receptor systems whose activity may have a profound influence on postural control and experienced orientation. Many patterns of behavior and response that have been attributed solely to vestibular function are actually dependent wholly or in part on touch, kinesthetic, and proprioceptive stimulation.  相似文献   
669.
    
A novel statistical method has been devised for evaluating the ground and the sky coverage of an observation experiment on board a satellite. Owing to its unrivalled rapidity compared with other conventional calculation techniques, the method can be applied to evaluate the coverage percentages for the whole globe or any area on it, to calculate the visibility percentages for one or more ground stations and to determine the percentages of observation time of any given celestial direction including Sun, Moon, Earth and Ground Stations constraints. The orbits considered can be elliptical and account is taken of the drift due to the Earth's oblateness.  相似文献   
670.
Analysis of four-frequency satellite Doppler data has allowed the separation and measurement of frequency-dependent ionospheric contributions to the Doppler shift, providing information useful in the study of errors incurred when tracking radio signals through the ionosphere. These refraction errors affect the accuracy of navigational position fixes obtained by Doppler satellite tracking systems. Some measured ionospheric refraction errors reported here are of interest because their magnitudes are significantly greater than those heretofore predicted from theoretical considerations.  相似文献   
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