Tissue responses to low protracted doses of high LET radiations or photons: early and late damage relevant to radio-protective countermeasures.

Early and late murine tissue responses to single or fractionated low doses of heavy charged particles, fission-spectrum neutrons or gamma rays are considered. Damage to the hematopoietic system is emphasized, but results on acute lethality, host response to challenge with transplanted leukemia cells and life-shortening are presented. Low dose rates per fraction were used in some neutron experiments. Split-dose lethality studies (LD 50/30) with fission neutrons indicated greater accumulation of injury during a 9 fraction course (over 17 days) than was the case for gamma-radiation. When total doses of 96 or 247 cGy of neutrons or gamma rays were given as a single dose or in 9 fractions, a significant sparing effect on femur CFU-S depression was observed for both radiation qualities during the first 11 days, but there was not an earlier return to normal with dose fractionation. During the 9 fraction sequence, a significant sparing effect of low dose rate on CFU-S depression was observed in both neutron and gamma-irradiated mice. CFU-S content at the end of the fractionation sequence did not correlate with measured LD 50/30. Sustained depression of femur and spleen CFU-S and a significant thrombocytopenia were observed when a total neutron dose of 240 cGy was given in 72 fractions over 24 weeks at low dose rates. The temporal aspects of CFU-S repopulation were different after a single versus fractionated neutron doses. The sustained reduction in the size of the CFU-S population was accompanied by an increase in the fraction in DNA synthesis. The proliferation characteristics and effects of age were different for radial CFU-S population closely associated with bone, compared with the axial population that can be readily aspirated from the femur. In aged irradiated animals, the CFU-S proliferation/redistribution response to typhoid vaccine showed both an age and radiation effect. After high single doses of neutrons or gamma rays, a significant age- and radiation-related deficiency in host defense mechanisms was detected by a shorter mean survival time following challenge with transplantable leukemia cells. Comparison of dose-response curves for life shortening after irradiation with fission-spectrum neutrons or high energy silicon particles indicated high initial slopes for both radiation qualities at low doses, but for higher doses of silicon, the effect per Gy decreased to a value similar to that for gamma rays. The two component life-shortening curve for silicon particles has implications for the potential efficacy of radioprotectants. Recent studies on protection against early and late effects by aminothiols, prostaglandins, and other compounds are discussed.     

Molecular spectroscopy of planetary atmospheres

Summary Clearly spectroscopy has already provided considerable insight into the nature of the planetary atmospheres. Several molecular constituents have been positively identified and upper limits have been placed on the abundances of others which are of particular significance in devising planetary models. But, equally clearly, the inadequacy of the spectral data, due to low spectral and/or spatial resolution, renders deductions of abundances, temperatures and pressures very uncertain. With the sole exception of the Martian CO₂ abundance, knowledge of the concentrations of planetary atmospheric constituents is unsatisfactory, and all numbers given must be regarded as only crude estimates. This latter comment applies equally well to the derived temperatures and pressures.What is urgently needed is the development of a reasonably complete theory of line formation in planetary atmospheres. This, coupled with more detailed spectroscopic work, should produce numerical values of atmospheric parameters which can be used with assurance.This work was performed with the aid of NASA Grant NsG-101-61 with funds administered by the University of California.     

Coronal radio-sounding detection of a CME during the 1997 Galileo solar conjunction

Frequency fluctuations of the Galileo S-band radio signal were recorded nearly continuously during the spacecraft’s solar conjunction from December 1996 to February 1997. A strong propagating disturbance, most probably associated with a coronal mass ejection (CME), was detected on 7 February when the radio ray path proximate point was on the west solar limb at about 54 solar radii from the Sun. The CME passage through the line of sight is characterized by a significant increase in the fluctuation intensity of the recorded frequency and by an increase in the plasma speed from about 234 km s⁻¹ up to about 755 km s⁻¹. These velocity estimates are obtained from a correlation analysis of frequency fluctuations recorded simultaneously at two widely-separated ground stations. The density turbulence power spectrum is found to steepen behind the CME front. The Galileo radio-sounding data are compared with SOHO/LASCO observations of the CME in the corona and with WIND spacecraft data near the Earth’s orbit.     

Performance limits of sensor-scheduling strategies in electronic support

The case is considered in which a frequency-agile receiver (FAR) for electronic support (ES) attempts to intercept radar emissions over a wide search bandwidth. It was recently shown [1,2] that a random strategy exists in which the expected intercept time can be made arbitrarily close to linear as a function of the scan period of the radar. Can a deterministic strategy be devised in which a similar linear relationship exists for the maximum intercept time? By applying the celebrated arithmetic results of van der Waerden [3] and Szemeredi [4], we show that no such strategy is possible.     

Transient Nonstationary Behavior of a Delay Line Discriminator

The development of numerical methods for studying the transient nonstationary behavior of a delay line discriminator is presented. Expressions are developed for the mean and the variance of the output noise process. For the cases where the output is stationary, power density spectra are found.     

Launch Envelope Optimization of Virtual Sliding Target Guidance Scheme

This paper presents an optimization of the performance of a recently proposed virtual sliding target (VST) guidance scheme in terms of maximization of its launch envelope for three-dimensional (3-D) engagements. The objective is to obtain the launch envelope of the missile using the VST guidance scheme for different lateral launch angles with respect to the line of sight (LOS) and demonstrate its superiority over kinematics-based guidance laws like proportional navigation (PN). The VST scheme uses PN as its basic guidance scheme and exploits the relation between the atmospheric properties, missile aerodynamic characteristics, and the optimal trajectory of the missile. The missile trajectory is shaped by controlling the instantaneous position and the speed of a virtual target which the missile pursues during the midcourse phase. In the proposed method it is shown that an appropriate value of initial position for the virtual target in 3-D, combined with optimized virtual target parameters, can significantly improve the launch envelope performance. The paper presents the formulation of the optimization problem, obtains the approximate models used to make the optimization problem more tractable, and finally presents the optimized performance of the missile in terms of launch envelope and shows significant improvement over kinematic-based guidance laws. The paper also proposes modification to the basic VST scheme. Some simulations using the full-fledged six degrees-of-freedom (6-DOF) models are also presented to validate the models and technique used.     

Detection of Thin Lines using Low-Quality Video from Low-Altitude Aircraft in Urban Settings

A novel thin line detection algorithm for use in low-altitude aerial vehicles is presented. This algorithm is able to detect thin obstacles such as cables, power lines, and wires. The system is intended to be used during urban search and rescue operations, capable of dealing with low-quality images, robust to image clutter, bad weather, and sensor artifacts. The detection process uses motion estimation at the pixel level, combined with edge detection, followed by a windowed Hough transform. The evidence of lines is tracked over time in the resulting parameter spaces using a dynamic line movement model. The algorithm's receiver operating characteristic curve (ROC) is shown, based on a multi-site dataset with 86 videos with 10160 wires spanning in 5576 frames.     

Development of an Italian low cost GNSS/INS system universally suitable for mobile mapping

The first studies for the mobile mapping and creation of a vehicle for this kind of research was carried out by Canadian Researchers in the 1980s. Since then, these vehicles have been widely employed in several applications (road cadastre maps, terrestrial photogrammihetry, road sign recognition, etc.) for both commercial and research purposes throughout the world. Many GNSSIINS vehicles which can be equipped in different ways with one or more GPS, inertial sensors, and one or several cameras, have been realized. A characteristic shared by most of these devices concerns the high costs of the sensors, of the realization and of the maintenance. For this reason, a GNSSIINS system, that is suitable for any vehicle, made up of low cost devices (two GPS receivers, an INS, and a camera rigidly placed on a metallic bar), has been designed and built by our research group. Two tests run at different velocities have been carried out to evaluate the reliability of the system. After a presentation of the system, the differences that were witnessed during the application of these calibration methods are explained herein.     

Prognostic Health Management of Aircraft Power Generators

In this paper, prognostic tools are developed to detect the onset of electrical failures in an aircraft power generator, and to predict the generator's remaining useful life (RUL). Focus is on the rotor circuit since failure mode, effects, and criticality analysis (FMECA) studies indicate that it is a high priority candidate for condition monitoring. A signature feature is developed and tested by seeded fault experiments to verify that the initial stages of rotor faults are observable under diverse generator load conditions. A tracking filter is used to assess the damage state and predict generator RUL. This information helps to avoid unexpected failures while reducing the overall life-cycle cost of the system.