The INFRARED SPACE OBSERVATORY (ISO)

The INFRARED SPACE OBSERVATORY (ISO), a project of the European Space Agency (ESA), will make various astronomical observations in the wavelength range of 2 to 200 μm. Two-thirds of its observing time will be available to guest observers via the traditional route of proposal submission. ISO will be launched in 1995 by an Ariane 4 from Kourou (Guyana) and be brought into a very elongated orbit with a 24hr period of which 16 hr can be used for astronomical observations. The payload module is essentially a large cryostat with a tank that will be filled with over 2000 litres of superfluid helium to keep the instruments cold (2 to 4 K) during an expected lifetime of 18 months. Inside the dewar, there is a Ritchey-Chretien telescope with a primary mirror of diameter 60cm. Four instruments, each provided by a different PI consortium, share the ISO focal plane. These instruments are : a photometer, a camera and two spectrometers — one for the wavelength range 2–45 μm and the other for 45–180 μm.     

Large lithium ion batteries for aerospace and aircraft applications

Eagle-Picher Energy Products (EPEP) has been manufacturing and testing large lithium ion cells (up to 100-Ah) for several years. Recently, work has focused on the testing of different chemistries at variable temperatures and designing and fabricating 100-Ah cylindrical cells. For the aircraft application the largest concern is irreversible capacity loss at elevated temperatures (70°C). In contrast, for the aerospace application shelf-life and cycle life are critical. EPEP has found that the major contributor to the loss in low temperature performance due to high temperature testing, was the positive electrode. EPEP discuss recent results of variable temperature cycling and 100-Ah cell performance     

Observer-type Kalman innovation filter for uncertain linear systems

An observer-type of Kalman innovation filtering algorithm to find a practically implementable "best" Kalman filter, and such an algorithm based on the evolutionary programming (EP) optima-search technique, are proposed, for linear discrete-time systems with time-invariant unknown-but-hounded plant and noise uncertainties. The worst-case parameter set from the stochastic uncertain system represented by the interval form with respect to the implemented "best" filter is also found in this work for demonstrating the effectiveness of the proposed filtering scheme. The new EP-based algorithm utilizes the global optima-searching capability of EP to find the optimal Kalman filter and state estimates at every iteration, which include both the best possible worst case Interval and the optimal nominal trajectory of the Kalman filtering estimates of the system state vectors. Simulation results are included to show that the new algorithm yields more accurate estimates and is less conservative as compared with other related robust filtering schemes     

Extracting multiple frequencies from phase-only data

The problem of extracting multiple frequencies from phase-only data is addressed. Multiple frequency estimation is accomplished by reconstructing the Fourier transform of the complex-valued time signal and then finding peaks in the frequency domain. We present a set of conditions under which a discrete-time complex sequence can be completely specified by its phase-only information. Two candidate multiple frequency estimation schemes are introduced, one based on a closed-form least-squares inverse, the other an iterative reconstruction algorithm. The uniqueness of the closed-form solution and the convergence of the iterative scheme have been proven under certain conditions. Several examples are given, including the case where the phase is quantized as would happen in an analog-to-digital (A/D) converter. Extensions to the multidimensional case, and to the case of real-part only reconstruction are straightforward.     

Paramecium--a model system for studying cellular graviperception.

Experiments under varied gravitational accelerations as well as in density-adjusted media showed that sensation of gravity in protists may be linked to the known principles of mechanosensation. Paramecium, a ciliate with clear graviresponses (gravitaxis and gravikinesis) is an ideal model system to prove this hypothesis since the ciliary activity and thus the swimming behaviour is controlled by the membrane potential. It has also been assumed that the cytoplasmic mass causes a distinct stimulation of the bipolarly distributed mechano-sensitive K+ and Ca2+ ion channels in the plasma membrane in dependence of the spatial orientation of the cell. In order to prove this hypothesis, different channel blockers are currently under investigation. Gadolinium did not inhibit gravitaxis in Paramecium, showing that it does not specifically block gravireceptors. Further studies concentrated on the question of whether second messengers are involved in the gravity signal transduction chain. Exposure to 5 g for up to 10 min led to a significant increase in cAMP.     

Electric currents induced inside biological cells by geomagnetic and atmospheric phenomena.

An increasing number of studies have appeared in the last ten years indicating that some pathologies may correlate with geomagnetic activity and cosmic rays. However a physical mechanism binding both phenomena has not been proposed. In the present work we obtain the amplitude of the magnetic fields at different frequencies, that may induce inside biological cells currents of the same magnitude of the currents generated by the cells themselves. We compare these values with the wave amplitudes produced in geomagnetic and atmospheric phenomena, and found that micropulsations, whistlers and lightning are capable of produce the same or larger values.     

Century scale solar variability imprinted in the 44Ti activity in meteorites.

The measurements of gamma-activity of the 44Ti (T1/2 = 66.6 years) produced by spallation reaction of galactic cosmic rays (GCR) in Alfianello, Olivenza, Rio Negro, Dhajala and Torino meteorites, which fell in the time interval 1883 AD (Alfianello)-1988 AD (Torino), show a century scale modulation, connected to long-term solar-wind flux variations in the interplanetary space. The variation of the 44Ti activity with the time of fall of meteorites is qualitatively consistent with the Gleissberg solar cycle, but the amplitude is three-four times higher than expected (about 5%) for GCR flux modulated by solar activity, as determined solely by the sunspot number. The cosmogenic 44Ti is a suitable radioisotope for this investigation, but its activity in meteorites is very low. We performed these measurements in the underground low level counting station of Monte dei Cappuccini in Torino, by means of a big hyperpure Ge crystal (approximately 2 kg) in selective coincidence with a heavy NaI (T1) scintillation detector (approximately 28 kg). This system allows a reliable and non destructive measurement of 44Ti (44Sc) in meteorites of 200-1200 g in weight. The background is about 1 count per day in the gamma-peak at 1157 keV of 44Sc in equilibrium with its parent 44Ti. The high stability of the performance allows long-lasting runs (approximately 10(7) s) in order to attain results with a standard deviation up to about 10%.     

Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation.

Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process.