X-ray induced alterations in the differentiation and mineralization potential of murine preosteoblastic cells

To evaluate the effects of ionizing radiation (IR) on murine preosteoblastic cell differentiation, we directed OCT-1 cells to the osteoblastic lineage by treatment with a combination of β-glycerophosphate (β-GP), ascorbic acid (AA), and dexamethasone (Dex). In vitro mineralization was evaluated based on histochemical staining and quantification of the hydroxyapatite content of the extracellular bone matrix. Expression of mRNA encoding Runx2, transforming growth factor β1 (TGF-β1), osteocalcin (OCN), and p21^CDKN1A was analyzed. Exposure to IR reduced the growth rate and diminished cell survival of OCT-1 cells under standard conditions. Notably, calcium content analysis revealed that deposition of mineralized matrix increased significantly under osteogenic conditions after X-ray exposure in a time-dependent manner. In this study, higher radiation doses exert significant overall effects on TGF-β1, OCN, and p21^CDKN1A gene expression, suggesting that gene expression following X-ray treatment is affected in a dose-dependent manner. Additionally, we verified that Runx2 was suppressed within 24 h after irradiation at 2 and 4 Gy. Although further studies are required to verify the molecular mechanism, our observations strongly suggest that treatment with IR markedly alters the differentiation and mineralization process of preosteoblastic cells.     

Simulation of the flow around a stationary circular cylinder taking into account laminar-turbulent transition

We consider a problem of a stationary incompressible viscous fluid flow around a flat circular cylinder. In the vicinity of the critical Reynolds number Re _cr a stepwise drop of the cylinder drag takes place, which is called the drag crisis.     

Local fracture of the burning solid propellant

The problem of fracture mechanics for the solid propellant deteriorated by a crack-shaped cavity, the surface of which burns is considered. It is assumed that the propellant reagents are uniformly distributed in the solid phase while the combustion products are gaseous. The sufficient condition for the “combustion -fracture” stability regime is obtained.     

Solar activity dependence of total electron content derived from GPS observations over Mbarara

Vertical total electron content (VTEC) observed at Mbarara (geographic co-ordinates: 0.60°S, 30.74°E; geomagnetic coordinates: 10.22°S, 102.36°E), Uganda, for the period 2001–2009 have been used to study the diurnal, seasonal and solar activity variations. The daily values of the 10.7 cm radio flux (F_10.7) and sunspot number (R) were used to represent Solar Extreme Ultraviolet Variability (EUV). VTEC is generally higher during high solar activity period for all the seasons and increases from 0600 h LT and reaches its maximum value within 1400 h–1500 h LT. All analysed linear and quadratic fits demonstrate positive VTEC-F_10.7 and positive VTEC-R correlation, with all fits at 0000 h and 1400 h LT being significant with a confidence level of 95% when both linear and quadratic models are used. All the fits at 0600 h LT are insignificant with a confidence level of 95%. Generally, over Mbarara, quadratic fit shows that VTEC saturates during all seasons for F_10.7 more than 200 units and R more than 150 units. The result of this study can be used to improve the International Reference Ionosphere (IRI) prediction of TEC around the equatorial region of the African sector.     

Programmable, multi-purpose opto-electronic sensor system

Optical fibre sensing is becoming increasingly attractive in both the smart structure sphere of interest as well as the medical and industrial concerns. Fibre-optic interferometric sensors can be designed as compact and robust transducers. In general, the transduction mechanism involves the phase modulation of coherent or monochromatic light propagating through a fibre-optic cable, and detecting the changes in the energy associated with this phase change. Sensors based on this technique can generally be configured to be quite sensitive and measurements of a wide variety of physical parameters are achievable. Intrinsic features of optical fibres, such as immunity to electromagnetic interference, flexibility, thinness, strength and weight, make this ideal for sensor technology. In the process of developing fibre-optic sensors for laboratory experimentation, as well as generalised research, an appropriate, easy to use opto-electronic drive and measurement system is required. This paper discusses the operation of a programmable opto-electronic drive and measurement system     

The Sun's Role in Long-Term Climate Change

Evidence suggests that changes of solar irradiance in recent centuries have provided a significant climate forcing and that the sun has been one of the principal causes of long-term climate change. During the past two decades the solar forcing has been much smaller than the climate forcing caused by increasing greenhouse gases. But it is incorrect to assume that the sun necessarily will be an insignificant player in climate change of the 21st century. Indeed, I argue that moderate success in curtailing the growth of anthropogenic climate forcings could leave the sun playing a pivotal role in future climate change.     

Identification of nonlinear flight dynamics: theory and practice

This article presents an innovative time-domain nonlinear mapping-based identification method. The method reported is applied to identify the unknown parameters of multivariable dynamic systems which are mapped by nonlinear differential equations. A systematic identification method is introduced, and a novel algorithm is developed using nonlinear error maps. An analysis of parameter convergence is provided and the regions of convergence can be found using the second method of Lyapunov. Innovative nonquadratic Lyapunov functions are designed and used. Analytical and numerical studies are performed to illustrate and validate the identification concept. The unsteady flight of a high-alpha aircraft in the longitudinal axis is chosen as a nonlinear case study. The unknown parameters are identified. Simulation results show that the model dynamics match the experimental data. The reported example demonstrates that the time-domain nonlinear mapping-based identification method ensures robustness and reduces major shortcomings in stability, convergence, and computational efficiency compared with other algorithms available     

Industry application of behavioral science

One of the more significant errors in the history of science occurred during the “marginal revolution” in economics near the end of the nineteenth century. Rather than explicitly recognize in basic theory that the happiness we seek to maximize in life originates within oneself, the early theorists formulated their equations as though human satisfaction resided in external things-as in so much utility (economist's term for satisfaction) per pound of sugar. Over the past 125 years, economists have developed mainstream mathematical economics on this incorrect basis resulting in the ill-founded neoclassical Equilibrium Theory. Because of this error economic theory is fundamentally timeless. The present theory, in its canonical form, corrects the early marginalist's error by identifying utility (time-integrated pleasure) exclusively with the stream-of-consciousness attending (expected) mental and physical activity. Time is now explicit in basic theory, thereby allowing, for the first time, the substantive computer-modeling of time-dependent, small- and large-scale economic systems. Furthermore, this new approach is methodologically compatible with mainstream sociology and institutional economics, allowing increased interdisciplinary cooperation that may influence policy and thereby affect industry and markets. And safety engineering stands to benefit from the accommodation of neuropsychology in understanding human error in the supervision and control of technology     

An analysis of temperature fields in rotating fluid

A possible variant presented for solving the equation of motion of a rotating flow is more general with respect to the variants known in the literature. On the basis of the simultaneous solution of the equations of motion and energy, the temperature fields are determined under changes of the rotation nature.