Induction of high grade astrocytoma (HGA) by protons: molecular mechanisms and RBE considerations.

Protons of a specific energy, 55 MeV, have been found to induce primary high grade astrocytomas (HGA) in the Rhesus monkey (Macaca mulatta). Brain tumors of this type were not induced by protons of other energies (32-2,300 MeV). Induction of HGA has been identified in human patients who have had radiation therapy to the head. We believe that the induction of HGA in the monkey is a consequence of dose distribution, not some unique "toxic" property of protons. Comparison of the human experience with the monkey data indicates the RBE for induction of brain tumors to be about one. It is unlikely that protons cause an unusual change in oncogenic expression, as compared to conventional electromagnetic radiation.     

Microgravity effects on "postural" muscle activity patterns.

Changes in neuromuscular activation patterns associated with movements made in microgravity can contribute to muscular atrophy. Using EMG to monitor "postural" muscles, it was found that free floating arm flexions made in microgravity were not always preceded by neuromuscular activation patterns normally observed during movements made in unit gravity. Additionally, manipulation of foot sensory input during microgravity arm flexion impacted upon anticipatory postural muscle activation.     

Development of plant protoplasts during the IML-1 mission.

During the 8 day IML-1 mission, regeneration of cell walls and cell divisions in rapeseed protoplasts were studied using the Biorack microscope onboard the Space Shuttle "Discovery". Samples from microgravity and 1g protoplast cultures were loaded on microscope slides. Visual microscopic observations were reported by the payload specialist Roberta Bondar, by down-link video transmission and by use of a microscope camera. Protoplasts grown under microgravity conditions do regenerate cell walls but to a lesser extent than under 1g. Cell divisions are delayed under microgravity. Few cell aggregates with maximum 4-6 cells per aggregate are formed under microgravity conditions, indicating that microgravity may have a profound influence on plant cell differentiation.     

A dissection of 30 Doradus and a discussion of other Magellanic Cloud OB associations

I Present the results of ground-based and Hubble Space Telescope photometry and spectroscopy of the stars in the central region (roughly 7×7 arcmin) of 30 Doradus in the Large Magellanic Cloud (LMC). Using photometric data for over 2400 stars (complete toV18 mag), and spectroscopic observations of over 150 stars in the region, the best estimate of the initial mass function (IMF) yields a slope of =–1.5±0.2 for masses > 12M, where the Salpeter slope is =–1.35. I compare these results to other measurements of the IMF for OB associations in the Magellanic Clouds.     

Nonlinear problems of physics of the geomagnetic pulsations

The current state of research involving manifestations of nonlinearity in geomagnetic pulsations is reviewed. Traditionally, the attention of researchers was focused on the effects of resonant interaction of geomagnetic pulsations with small groups of energetic particles, which actually means the study of the quasi-linear relaxation of radiation belt ions, the modulation of auroral electron fluxes, etc. The present review concentrates on the problem of the nonlinear effect influence of pulsations on the backgroud (cold) plasma and on the geomagnetic field. This kind of interaction results in a significant modification of the plasma distribution in the magnetosphere. Self-consistent wave structures—solitons and vortices may occur as well. Such nonlinear effects contribute to physics of geomagnetic pulsations and are also of fundamental importance for general physics. Another set of more narrow problems considered in the review, is related to phenomenological modeling of fluctuational and critical phenomena in the magnetosphere. The essence of our approach is to present the magnetosphere as a black box, whose properties should be determined by the statistical characteristics of its output signals. This approach to phenomenology can be a useful supplement to the methods of microscopic modeling aimed at detecting nonlinear manifestations of geomagnetic pulsations.     

The fundamental parameters of the central stars of eight WR ring nebulae

We describe work that has recently been completed on deriving the fundamental parameters of eight WR stars through the photoionization modelling of their surrounding nebulae using non-LTE WR flux distributions. The resulting effective temperatures range from 57 000–71 000 K for the WN4-5 stars and <30 000–42 000 K for the WN6-8 stars. The derived stellar parameters are compared with those obtained from stellar emission line modelling. We find good agreement for the hot early WN stars, indicating that the non-LTE WR flux distributions have essentially the correct shape in the crucial far-UV region. We find lower temperatures for the four cooler late WN stars, particularly for the two WN6 stars. For the nebulae surrounding these stars, we find that the model flux distributions produce too much nebular ionization. We suggest that these discrepancies arise because of the lack of line-blanketing in the WR atmospheres. For the WO1 central star of G2.4+1.4, with strong nebular He II 4686 A emission, we derive a temperature of 105 000 K, somewhat less than previous estimates. The positions of our eight WR stars on the H-R diagram are compared with the evolutionary tracks of Maeder (1990) for solar metallicity. In common with previous workers, we find that our derived luminosities are too low, giving an initial mass range of 25–40 M, below that expected for the majority of WR stars.     

The impact of semi-convection and overshooting on the surface abundances in massive stars

We analyse the effects of semi-convection and overshooting on the predicted surface abundances after the first and second dredge-ups in 15 and 20 M Pop. I stars. Overshooting is applied either to the core boundary or to the boundaries of all convective zones. It is shown that the surface abundances are sensitive to the mixing scheme adopted in the interior. The models including semi-convection lead to lower¹²C/¹³C ratios than the other mixing schemes, while models with overshooting predict higher enhancements of sodium at the surface.     

The complex Hα profile of the hypergiant HR 8752 during 1970–1992

The profiles of H observed during the 1970–1992 period in the binary hypergiant HR 8752 (G0 Ia) are presented. We distinguish five typical H profiles designated as A, B, C, D and E types according to the number of emission and absorption features. The profiles of H are complex and contain several emission and absorption components, with: –130 km/s in emission or absorption, –84 km/s in absorption, –49 km/s in emission and about +6 km/s in emission. All of them are rather stable in radial velocities except of the main absorption component in the P Cygni profile with –84 km/s. The frequency of appearance and the periods of duration of the occurrence of the components is discussed. The duration times range between about 3 to 10 months for various components. The red emission component E₂ is particularly interesting. Possible explanations of its origin are discussed.A long-term acceleration of the absorption component in the P Cygni profile is found; it can be interpreted as monotonous acceleration of the stellar wind.     

Wind asymmetries in massive stars

We are in the process of surveying the linear polarization in luminous, early-type stars. We here report on new observations of the B [e] stars S 18 and R 50, and of the Luminous Blue Variables HR Car, R 143, and HD 160529. Together with previously published data, these observations provide clear evidence for the presence of intrinsic polarization in 1 B[e] star (HD 34664) and in 5 LBVs ( Car, P Cyg, R 127, AG Car, and HR Car). The data indicate that anisotropic stellar winds are a common occurrence among massive stars in these particular evolutionary stages. For such stars, mass-loss rates estimated using the assumption of a spherical, homogeneous and stationary outflow may be in error.     

Co2 and Climate: a Geologist's View

Climate is discussed as an integral part of System Earth, determined by a complex interplay of numerous geological, biological and solar processes. The historical and geological record of changing climate and atmospheric CO₂ pressure does not support the current popular vision that this greenhouse gas is the dominant climate controlling agent. When empirically ante post tested against past global climate changes, the forecasts of the climate models mainly based on forcing by atmospheric CO₂ are not borne out. On the other hand, recent studies show that solar variability rather than changing CO₂ pressure is an important, probably the dominant climate forcing factor.