Biochemical constraints for survival under Martian conditions.

A wide variety of terrestrial organisms, the so-called "anhydrobiotes," has learned to survive in a state of extreme dehydration in dry environments. Strategies for survival include the accumulation of certain polyols and nonreducing saccharides, which help to prevent damage to membranes and proteins, but at low water partial pressure DNA is also progressively damaged by various lesions, including strand breaks and cross-linking to proteins. These lesions, if they are not too numerous, can be repaired before the first replication step after rehydration, but long-term exposure to dry conditions finally diminishes the chances of survival as these lesions accumulate. If an organism has no chance to repair the accumulated DNA damage during intermittent periods of active life, survival will not exceed a few decades. The restriction of survival by dryness-induced DNA lesions is corroborated by new data on conidia of Aspergillus and the free plasmid pBR 322. Our results will be discussed with respect to the chance of finding dormant life or biochemical fossils on the surface of Mars.     

Leg venous hemodynamics and leg volumes during a 42 day -6 degrees head-down bedrest

Seven healthy subjects were submitted to a 42-day head down bedrest, where leg venous compliance (venous distensibity index VDI) and leg volumes were assessed by mercury strain gauge plethysmography with venous occlusion and optoelectronic plethysmography, respectively. Plethysmographic and volometric measurements were made, before, during (at days 1, 4, 7, 14, 21, 26, 34 and 41), and after bedrest (days 1, 4, 7, 11 and 30 of the recovery period). Results showed a continuous decrease in leg volumes throughout bedrest, when VDI increased until day 26 of bedrest, and then decreased afterwards. The recovery period was characterized by a rapid return of VDI to prebedrest levels while leg volumes progressively normalised. These results showed that leg venous compliance changes are not always dependant upon skeletal muscle changes, and that factors other than size of muscle compartment are able to determine increases in leg venous compliance during long-term bedrest.     

Spatial orientation during locomotion [correction of locomation] following space flight

To investigate changes in spatial orientation ability and walking performance following space flight, 7 astronaut subjects were asked pre- and post-flight to perform a goal directed locomotion paradigm which consisted of walking a triangular path with and without vision. This new paradigm, involving inputs from different sensory systems, allows quantification of several critical parameters, like orientation performance, walking velocities and postural stability, in a natural walking task. The paper presented here mainly focusses on spatial orientation performance quantified by the errors in walking the previously seen path without vision. Errors in length and reaching the corners did not change significantly from pre- to post-flight, while absolute angular errors slightly increased post-flight. The significant decrease in walking velocity and a change in head-trunk coordination while walking around the corners of the path observed post-flight may suggest that during re-adaptation to gravity the mechanisms which are necessary to perform the task have to be re-accomplished.     

On the correlation between individual biochemical parameters of human blood serum following space flight and their basal values

The article presents data concerning the osmolality and concentration of electrolytes and hormones regulating their balance for blood serum of 223 cosmonauts and astronauts. The obtained results allow us to judge the constancy of physicochemical parameters for the blood serum of healthy individuals and how they react to extreme conditions of space flight. The parameters used for evaluation included not just absolute values for the examined indices, but also how they responded to space flight, the dependence on baseline values and the interrelationship between ions. These data are important to predict the effect of exposure to extreme conditions and point to what extent the effect depends on the characteristics of the individual.     

Highly mobile space suit material optimization

This paper discusses the factors that control the flexibility of fabric space suit elements by examining a bending model of a pressurized fabric tube. Results from the model are used to evaluate the current direction in highly mobile EVA glove research and suggest that changes are necessary in the suit and glove fabric selection methodology.     

Life in space may help life on Earth

Teams of chronobiologists from the U.S., Russia, and Japan are working toward a remote computerized health care system which, once tested in space, may change how doctors diagnose and treat cardiovascular diseases, including hypertension and conditions predisposing stroke. The system is based on ongoing research indicating that swings in blood pressure charted over a span of 24 hr or longer, rather than a single systolic and diastolic reading, can reveal a new major risk factor for heart disease.     

绿色制造中的干切削技术

冷却润滑液的存储、使用以及废弃处理需要专门的物流系统,因而费用很高;冷却润滑液处理不当会对人的健康以及环境造成危害;工件经过湿加工后必须进行清洁处理,这都费时费力,同时增加了对系统的要求.基于上述原因,近年来干切削技术受到广泛关注.     

Finite-dimensional filters with nonlinear drift. V: solution to Kolmogorov equation arising from linear filtering with non-Gaussian initial condition

Despite its usefulness, the Kalman-Bucy filter is not perfect. One of its weaknesses is that it needs a Gaussian assumption on the initial data. Recently Yau and Yau introduced a new direct method to solve the estimation problem for linear filtering with non-Gaussian initial data. They factored the problem into two parts: (1) the on-line solution of a finite system of ordinary differential equations (ODEs), and (2) the off-line calculation of the Kolmogorov equation. Here we derive an explicit closed-form solution of the Kolmogorov equation. We also give some properties and conduct a numerical study of the solution.     

Interference between FM Carriers and a Digitally Modulated SCPC Circuit

The interference from the digital single channel per carrier (SCPC) circuits into frequency-modulated carrier systems has been calculated by convolving the desired and the interfering spectra extending the previously published works. Resulting interference noise power in FDM/FM systems covering a wide range of modulation indices and basebands has been presnted. Also plots of interference noise power as a function of the number of SCPC circuits have been presented for various values of carrier power to interference power ratios.     

Discrete-time observability and estimability analysis for bearings-only target motion analysis

Observability in the context of bearings-only tracking (BOT) is still the subject of important literature. Different from previous approaches, where continuous-time analysis was considered, our approach relies on discrete-time analysis. It is then shown that this allows us to use directly and efficiently the simple formalisms of linear algebra. Using the direct approach, observability analysis is essentially reduced to basic considerations about subspace dimensions. Even if this approach is conceptually quite direct, it becomes more and more complex as the source-encounter scenario complexity increases. For complex scenarios, the dual approach may present some advantages essentially due to the direct use of multilinear algebra. New results about BOT observability for maneuvering sources are thus obtained. Observability analysis is then extended to unknown instants of source velocity changes. Even if observability analysis provides thorough insights about the algebraic structure of the BOT problem, the optimization of the observer maneuvers is essentially a control problem. Basic algebraic considerations prove that a relevant cost functional for this control problem is the determinant of the Fisher information matrix (FIM). So, a large part of this work is devoted to the analysis of this cost functional. Using multilinear algebra, general approximations of this functional are given. In order to involve only directly estimable parameters, the source bearing-rates are examined. Using these approximations, a general framework for optimizing the observer trajectory is derived which allow us to approximate the optimal sequence of controls. It is worth stressing that our approach does not require the knowledge of the source trajectory parameters and is still valid for a maneuvering source.