Effect of track structure and radioprotectors on the induction of oncogenic transformation in murine fibroblasts by heavy ions

The oncogenic potential of high-energy ⁵⁶Fe particles (1 GeV/nucleon) accelerated with the Alternating Gradient Synchrotron at the Brookhaven National Laboratory was examined utilizing the mouse C3H 10T1/2 cell model. The dose-averaged LET for high-energy ⁵⁶Fe is estimated to be 143 keV/μm with the exposure conditions used in this study. For ⁵⁶Fe ions, the maximum relative biological effectiveness (RBE_max) values for cell survival and oncogenic transformation were 7.71 and 16.5 respectively. Compared to 150 keV/μm ⁴He nuclei, high-energy ⁵⁶Fe nuclei were significantly less effective in cell killing and oncogenic induction. The prostaglandin E₁ analog misoprostol, an effective oncoprotector of C3H 10T1/2 cells exposed to X rays, was evaluated for its potential as a radioprotector of oncogenic transformation with high-energy ⁵⁶Fe. Exposure of cells to misoprostol did not alter ⁵⁶Fe cytotoxicity or the rate of ⁵⁶Fe-induced oncogenic transformation.     

BBXRT and Ginga observations of AGN

The X-ray properties of Active Galactic Nuclei (AGN) support recent theories which unify the Seyfert 1 nuclei with the Seyfert 2's and radio-quiet quasars. In these objects the underlying spectrum is strongly distorted by the effects of reflection from the accretion flow and by absorption in partially ionised material. These obscure any intrinsic changes in the spectrum, making it difficult (though not impossible) to constrain the nature of the emission process. Conversely, there is no evidence for either of these spectral distortions in the radio-loud AGN, supporting the hypothesis that the X-rays are dominated by beamed emission from the relativistic jet.     

Space robotics in the '90s

This article describes the use of robots to perform work in space. In particular, telerobotics, which uses human operators to control the movement and operation of the robots, are explored. The relationship between the human operator and the robot is very complex but these systems are being used to explore planetary surfaces and will also be used in the construction of the space station. Research being conducted at NASA facilities is described, providing a picture of the future of space robotics.     

Comparisons between primrose lake (54°N, 110°W) ROCOB winds (20–60 km) and Saskatoon (52°N, 107°W) M. F. radar winds (60–110 km): 1978–1982

The development of the new CIRA will require the combination of winds from many sources, e.g. rockets (ROCOB) up to ～60 km, and radar winds ～60–110 km. Difficulties are that such rocket data have larger errors at 60–65 km, and tidal effects may become significant. Radar data for 60–80 km may also have tidal contamination, due to ? 16h of data per day: from 80–110 km tidal corrections are usually reliable.Comparisons are made between the unique Saskatoon MF radar set, which is continuous from mid 1978–1983, and the ROCOB data from Primrose Lake, which is only 340 km northwest. While the agreement is satisfactory, special care is required when matching the two regions: particular problems are the low rocket sampling rate, and the unexpectedly large amplitude of the diurnal tide. Important differences from the zonal winds of CIRA-72 emerge, especially in winter months. Meridional cross-sections differ from previous data models in the extent of the summer equatorward flow.     

The variability of stratospheric nitrogen compounds observed by LIMS in the winter of 1978–1979

The LIMS experiment was launched on the Nimbus 7 satellite for the purpose of sounding the vertical structure of temperature and key upper atmosphere trace gases on a global scale. The technique of thermal infrared limb sounding was used to obtain measurements of O₃, H₂O, NO₂, and HNO₃. LIMS collected data almost continuously from late October to late May over the latitude range from 64°S to 84°N. Two of the gases, NO₂ and HNO₃, are important elements in the NO_x chain of chemical reactions leading to ozone destruction. We will describe results for these gases in terms of zonal mean profiles and latitudinal distributions. The period selected for study is January–May 1979, when a major stratospheric warming occurred.     

Amorphous Silicon Electronic Devices and their Applications

Hydrogenated amorphous Si (a-Si:H) devices first made a significant impact in photovoltaic application, 70% of the photovoltaic solar cells produced in Japan in 1984 were a-Si:H. More recently, thin film transistor (TFT) and sensor devices have been developed for consumer and business products. The ability to produce large area uniform films of a-Si:H makes the application of TFTs and sensors well suited for input and output imaging devices such as image scanners, display and printers. This paper reviews the operation, material issues and physics of a-Si:H TFTs and sensors. The circuit and technology issues in large area systems incorporating these devices are described.     

The biological clock of Neurospora in a microgravity environment.

The circadian rhythm of conidiation in Neurospora crassa is thought to be an endogenously derived circadian oscillation; however, several investigators have suggested that circadian rhythms may, instead, be driven by some geophysical time cue(s). An experiment was conducted on space shuttle flight STS-9 in order to test this hypothesis; during the first 7-8 cycles in space, there were several minor alterations observed in the conidiation rhythm, including an increase in the period of the oscillation, an increase in the variability of the growth rate and a diminished rhythm amplitude, which eventually damped out in 25% of the flight tubes. On day seven of flight, the tubes were exposed to light while their growth fronts were marked. Some aspect of the marking process reinstated a robust rhythm in all the tubes which continued throughout the remainder of the flight. These results from the last 86 hours of flight demonstrated that the rhythm can persist in space. Since the aberrant rhythmicity occurred prior to the marking procedure, but not after, it was hypothesized that the damping on STS-9 may have resulted from the hypergravity pulse of launch. To test this hypothesis, we conducted investigations into the effects of altered gravitational forces on conidiation. Exposure to hypergravity (via centrifugation), simulated microgravity (via the use of a clinostat) and altered orientations (via alterations in the vector of a 1 g force) were used to examine the effects of gravity upon the circadian rhythm of conidiation.     

Status of the Hubble Space Telescope observatory

The Hubble Space Telescope activity by NASA and ESA began in 1971 and is now nearing completion. The Scientific Instruments are complete and their performance confirmed. The Optical Telescope Assembly integration is proceeding well, with the crucial Fine Guidance Sensors expected to perform as designed. Telescope delivery to the spacecraft contractor is expected in December 1984. Completion of the Verification and Assembly Program will then be followed by launch in the summer of 1986.