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31.
Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation. 总被引:3,自引:0,他引:3
T K Hei Y L Zhao D Roy C Q Piao G Calaf E J Hall 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2001,27(2):411-419
Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process. 相似文献
32.
K. Uesugi 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1991,11(12):19-27
A chronological review of studies in ISAS concerning collisions in space is presented. The collision probability in space with artificial orbiting bodies was estimated, and a Space Traffic Control System was proposed, in 1971. The design of a space station for safety against collision hazards was discussed in 1972. A trajectory optimization technique for low-thrust multiple rendezvous mission in order ti sweep space debris around the earth was developed in 1977. In 1984, the collision probability was reestimated using space bedris data accumulated for more than a decade. Several experimental projects in ISAS, such as hypervelocity impact experiments using a railgun system, sampling and measuring of alumina particles in exhaust plume of solid-propellant propellant rocket motors, and a result of analysis on the behavior of such alumina particles in orbit are also introduced. 相似文献
33.
Fisher H.L. Musser K.L. Shuster M.D. 《IEEE transactions on aerospace and electronic systems》1993,29(1):22-26
Attitude estimation algorithms for the Thrusted Vector Mission which determine attitude based on Sun sensor and very coarse albedo sensor measurements are presented. On the basis of these measurements, it has been demonstrated by comparison with more accurate gyro-based attitude that it is possible to estimate three-axis attitude with an average error per axis of 11 deg. Most of this error is about the Sun direction. Both deterministic quick-look and optimal estimates are examined 相似文献
34.
Khan M.H. Le-Ngoc T. Bhargava V.K. 《IEEE transactions on aerospace and electronic systems》1985,(4):547-558
Two hybrid schemes of time-frequency resource sharing to increase the rain margin of Ku-and Ka-band satellite systems are proposed. Scheme 1 requires sharing a small pool of bandwidth for adaptive forward error control coding, sharing a small pool of time frame for rate reduction, and sharing a portion of low frequency time-division multiple access (TDMA) back-up frame for downlink transmission to the rain affected stations. Scheme 2 utilizes variable rate modulation and forward error correction, shares a small pool of time frame for rate reduction, and shares a portion of low frequency TDMA back-up frame. Effective usable capacities of the system using these schemes are calculated. Distribution of resources in order to maximize the effective usable capacity is also analyzed. The results obtained are compared with other adaptive schemes. Preliminary analysis shows that the utilized capacity of scheme 1 exceeds 99 percent of the effective usable capacity possible if it never rains for an outage of 0.05 percent and fade margin of 2.5 dB. For scheme 2 similar performance is achievable at a fade margin of 1.5 dB. For higher outage objectives the loss of effective utilized capacity is higher for scheme 2. 相似文献
35.
K. Jahoda 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1993,13(12):231-240
A more appropriate title for this talk would have been “Measurements of Large Scale Structure from X-ray Background Fluctuations”. While it has long been recognized that the X-ray Background (XRB) is primarily of a cosmological origin (with z < a few), it has recently become apparent that surface brightness fluctuations in the surveys of the XRB can be used to trace the distribution of matter in much the same way as complete catalogs of individual objects. The distance which is probed is related to the angular resolution of the detector; for the HEAO-1 A2 experiment, which provides the best all-sky data base for the XRB in the 2–20 keV band, the effective depth is a few 100 Mpc. 相似文献
36.
H. Awaki K. Koyama 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1993,13(12):221-230
We observed twenty-eight Seyfert 2 galaxies with the Japanese X-ray satellite, Ginga, and found Seyfert 2 galaxies, in general, have the X-ray spectral characteristics of obscured Seyfert 1 nuclei. This result agrees with the predictions from Unified Seyfert model proposed by Antonucci and Miller /1/. However, among the observed Seyfert 2 galaxies, there are a few galaxies with no evidence of an obscuration, contrary to the general predictions of the unified model. We note that type 2 AGN will contribute to the Cosmic Diffuse X-ray Background, if the unified Seyfert model can be extended to the far distant AGN such as quasars. 相似文献
37.
A data fusion model consisting of several levels of parallel decision fusions is considered. Global optimization of such a model is discussed to obtain the fusion rules for overall optimal performance. The reliability analysis of the proposed model is carried out to establish its superiority over the existing parallel and serial fusion models 相似文献
38.
The design of fault-tolerant distributed control systems is discussed. The application described is a generic flight control system (FCS) for a fighter aircraft. The system is designed for high redundancy and expandability to meet various requirements. The communication network is based on the fiber distributed data interface (FDDI), which provides a high level of electromagnetic interference resistance and reliability. The choice of fiber optic media also provides an extremely high bandwidth and tremendous growth capability for future communications needs. This study is not specific to FDDI or flight control systems. The methods and configurations presented should be applicable to many real-time control implementations 相似文献
39.
D. Koschny V. Dhiri K. Wirth J. Zender R. Solaz R. Hoofs R. Laureijs T.-M Ho B. Davidsson G. Schwehm 《Space Science Reviews》2007,128(1-4):167-188
ESA’s Rosetta mission was launched in March 2004 and is on its way to comet 67P/Churyumov-Gerasimenko, where it is scheduled
to arrive in summer 2014. It comprises a payload of 12 scientific instruments and a Lander. All instruments are provided by
Principal Investigators, which are responsible for their operations.
As for most ESA science missions, the ground segment of the mission consists of a Mission Operations Centre (MOC) and a Science
Operations Centre (SOC). While the MOC is responsible for all spacecraft-related aspects and the final uplink of all command
timelines to the spacecraft, the scientific operations of the instruments and the collection of the data and ingestion into
the Planetary Science Archive are coordinated by the SOC. This paper focuses on the tasks of the SOC and in particular on
the methodology and constraints to convert the scientific goals of the Rosetta mission to operational timelines. 相似文献
40.
Maciel J.J. Slocum J.F. Smith J.K. Turtle J. 《Aerospace and Electronic Systems Magazine, IEEE》2007,22(11):17-20
Large apertures are of great benefit to applications that are prime powered limited as is found on aerostat and other airborne platforms. Electronically scanned array antennas are often proposed for these applications. However, increasing the aperture area with conventional array technology is met with prohibitive cost, weight, and prime power increases because of the dense spacing of phase shifters and/or active T/R modules. This discusses the recent development of RF MEMS (Microelectromechanical System) switch technology and the use of these switches in a Radanttrade lens configuration for arrays of approximately 10 m2 at X-band. A proof-of-concept 0.4 m2 MEMS Electronically Steerable Antenna (ESA) containing 25,000 MEMS switches has been successfully designed, fabricated, and tested. The 0.4 m2 MEMS ESA was then integrated with an AN/APG-67 radar system to form the MEMS Demonstration Radar System. The MEMS Demonstration Radar System successfully detected both airborne and ground moving targets during a series of extensive radar demonstrations. This is believed to be the first large scale employment of MEMS switches in a scanning antenna and radar system. The low-cost, lightweight, and low power technology demonstrated can enable weight and power constrained platforms with electronic steering. 相似文献