Study of physiological effects of weightlessness and artificial gravity in the flight of the biosatellite Cosmos-936.

In the 18.5-day flight of the Soviet biosatellite Cosmos-936 (3-22, August 1977) com-parative investigations of the physiological effects of prolonged weightlessness (20 rats) and artificial gravity of 1 g (10 rats) were carried out. Throughout the flight artificial gravity was generated by means of animal rotation in two centrifuges with a radius of 320mm. Postflight examination of animals and treatment of the flight data were performed by Soviet scientists in collaboration with the specialists from Bulgaria, Czechoslovakia, the German Democratic Republic, Hungary, Poland, Rumania, France and the U.S.A. During the flight the total motor activity of the weightless rats was higher and their body temperature was lower than those of the centrifuged animals. Postflight examination of the weightless rats showed a greater percentage of errors during maze an increase in water intake and a decrease in diuresis; a fall of the resistance of peripheral red cells; an increase in the conditionally pathogenic microflora in the mouth; a decrease of oxygen consumption, carbon dioxide production and energy expenditures; a drop in the static physical endurance; a decline in the capacity to keep balance on the rail; an increase in the latent period of the lifting reflex, etc. The centrifugal animals displayed lesser or no change of the above type. These findings together with the biochemical and morphological data give evidence that during and after flight adaptive processes in the centrifuged rats developed better.     

Species and temperature exchange in the atmosphere of “BION-M” spacecraft

On going flights of Foton satellites allow to carry out research in the following domains: effect of space flight and outer space factors such as microgravity, artificial gravity and space radiation on physical processes and biological organisms. Experts from many Russian and foreign scientific institutions participated in the research. Over a period of time from 1973 to 1997 there were launched 11 BION satellites designed by the Central Specialized Design Bureau for carrying out fundamental and applied research in the field of space biology, medicine, radio physics and radiobiology with participation of specialists from the foreign countries.The goal of the present investigation was in developing a numerical simulator aimed at determining gas concentration and temperature fields established inside the scientific module of the spacecraft “Bion-M” and to perform optimization studies, which could meet strong requirements for air quality and temperature range allowable for operation of different biological experiments.     

Adsorption of amino acids (ALA, CYS, HIS, MET) on zeolites: fourier transform infrared and Raman spectroscopy investigations

Minerals adsorb more amino acids with charged R-groups than amino acids with uncharged R-groups. Thus, the peptides that form from the condensation of amino acids on the surface of minerals should be composed of amino acid residues that are more charged than uncharged. However, most of the amino acids (74%) in today's proteins have an uncharged R-group. One mechanism with which to solve this paradox is the use of organophilic minerals such as zeolites. Over the range of pH (pH 2.66-4.50) used in these experiments, the R-group of histidine (His) is positively charged and neutral for alanine (Ala), cysteine (Cys), and methionine (Met). In acidic hydrothermal environments, the pH could be even lower than those used in this study. For the pH range studied, the zeolites were negatively charged, and the overall charge of all amino acids was positive. The conditions used here approximate those of prebiotic Earth. The most important finding of this work is that the relative concentrations of each amino acid (X=His, Met, Cys) to alanine (X/Ala) are close to 1.00. This is an important result with regard to prebiotic chemistry because it could be a solution for the paradox stated above. Pore size did not affect the adsorption of Cys and Met on zeolites, and the Si/Al ratio did not affect the adsorption of Cys, His, and Met. ZSM-5 could be used for the purification of Cys from other amino acids (Student-Newman-Keuls test, p<0.05), and mordenite could be used for separation of amino acids from each other (Student-Newman-Keuls test, p<0.05). As shown by Fourier transform infrared (FT-IR) spectra, Ala interacts with zeolites through the [Formula: see text] group, and methionine-zeolite interactions involve the COO, [Formula: see text], and CH(3) groups. FT-IR spectra show that the interaction between the zeolites and His is weak. Cys showed higher adsorption on all zeolites; however, the hydrophobic Van der Waals interaction between zeolites and Cys is too weak to produce any structural changes in the Cys groups (amine, carboxylic, sulfhydryl, etc.); thus, the FT-IR and Raman spectra are the same as those of solid Cys.     

Tether Satellite System Collision Study

A study was performed to determine the probability of collision with resident space objects and untrackable debris for the tether component of the Tethered Satellite System (TSS) after it broke away from the Space Shuttle orbiter (mission STS-75) in February 1996. Both an analytical and a numerical approach were used in this study, and the results obtained with these two methods were found to be in good agreement. These results show that the deployed tether is expected to have been impacted by several particles 0.1mm or larger in size. The probability of collision with objects 10cm in size or larger was on the order of 10^–3 per month. Since the severed tether reentered within one month after deployment, the collision hazard to other objects while in orbit was small. The analytical methods used in this study are useful for tether collision evaluations in general.     

Asymptotic theory for thrusting,spinning-up spacecraft maneuvers

We consider the problem of a spacecraft subjected to constant body-fixed forces and moments about all three axes during a spinning-up, thrusting maneuver. In applications, undesired forces and moments can arise due to thruster imbalances and misalignments and to center-of-mass offset. In previous works, approximate analytical solutions have been found for the attitude motion, and for the change in inertial velocity and inertial position. In this paper we find asymptotic and limiting-case expressions which we derive from the analytic solutions, in order to obtain simplified, practical formulas that lend insight into the motion. Specifically, we investigate how the motion evolves (1) as time grows without bound and (2) for geometric cases of the sphere, the thin rod, and the thin plate. Closed-forms or upper-bound limits are provided for angular velocities, Eulerian angles, angular momentum pointing error, transverse and axial velocities, and transverse and axial displacements. Summaries for the asymptotic limits (for zero initial conditions) are provided in tabular form. Results are verified by numerical simulations.     

Satellite dynamics under the influence of gravitational and aerodynamic torques. A study of stability of equilibrium positions

The dynamics of the rotational motion of a satellite, moving in the central Newtonian force field under the influence of gravitational and aerodynamic torques, is investigated. The paper proposes a method for determining all equilibrium positions (equilibrium orientations) of a satellite in the orbital coordinate system for specified values of aerodynamic torque and the major central moments of inertia; the sufficient conditions for their existence are obtained. For each equilibrium orientation the sufficient stability conditions are obtained using the generalized energy integral as the Lyapunov function. The detailed numerical analysis of the regions where the stability conditions of the equilibrium positions are satisfied is carried out depending on four dimensionless parameters of the problem. It is shown that, in the general case, the number of satellite’s equilibrium positions, for which the sufficient stability conditions are satisfied, varies from 4 to 2 with an increase in the value of the aerodynamic torque magnitude.     

System identification of dynamic closed-loop control of total peripheral resistance by arterial and cardiopulmonary baroreceptors.

Prolonged exposure to microgravity in space flight missions (days) impairs the mechanisms responsible for defense of arterial blood pressure (ABP) and cardiac output (CO) against orthostatic stress in the post-flight period. The mechanisms responsible for the observed orthostatic intolerance are not yet completely understood. Additionally, effective counter measures to attenuate this pathophysiological response are not available. The aim of this study was to investigate the ability of our proposed system identification method to predict closed-loop dynamic changes in TPR induced by changes in mean arterial pressure (MAP) and right atrial pressure (RAP). For this purpose we designed and employed a novel experimental animal model for the examination of arterial and cardiopulmonary baroreceptors in the dynamic closed-loop control of total peripheral resistance (TPR), and applied system identification to the analysis of beat-to-beat fluctuations in the measured signals. Grant numbers: NAG5-4989.