Upregulation of erythropoietin receptor in UT-7/EPO cells inhibits simulated microgravity-induced cell apoptosis

Hematopoietic progenitor cell proliferation can be altered in either spaceflight or under simulated microgravity experiments on the ground, however, the underlying mechanism remains unknown. Our previous study showed that exposure of the human erythropoietin (EPO)-dependent leukemia cell line UT-7/EPO to conditions of simulated microgravity significantly inhibited the cellular proliferation rate and induced cell apoptosis. We postulated that the downregulation of the erythropoietin receptor (EPOR) expression in UT-7/EPO cells under simulated microgravity may be a possible reason for microgravity triggered apoptosis. In this paper, a human EPOR gene was transferred into UT-7/EPO cells and the resulting expression of EPOR on the surface of UT-7/EPO cells increased approximately 61% (p < 0.05) as selected by the antibiotic G418. It was also shown through cytometry assays and morphological observations that microgravity-induced apoptosis markedly decreased in these UT-7/EPO–EPOR cells. Thus, we concluded that upregulation of EPOR in UT-7/EPO cells could inhibit the simulated microgravity-induced cell apoptosis in this EPO dependent cell line.     

基于B/S架构的设备全寿命周期管理系统技术研究

研究了基于B/S架构(Browser/Server结构)的设备全寿命周期管理系统相关技术,论述了构成设备全寿命周期管理系统的架构设计与模块划分。将网络、多媒体、数据库等技术通过计算机软件系统开发的理论、技术和方法建立起的B/S架构应用于航空聚合物基复合材料厂的设备管理。该系统可使相关基础管理工作以信息化手段简化、固化与落实。     

Kalman filtering for GPS/magnetometer integrated navigation system

This paper investigated the data processing method for a GPS/IMU/magnetometer integrated system with Kalman filtering (KF). As a result of GPS/IMU/magnetometer land vehicle system, dead-reckoning of magnetometer and accelerometer integrated subsystem bridged very well the GPS signal outage due to the trees on the two sides of the road. Both differential GPS data processing method and the carrier-phase method with magnetometers’ outputs for predicting the car position, velocity, and acceleration (PVA) are presented. The results from DGPS with Kinematical Positioning (KINPOS) software shown that the averages of the north, east, and down direction standard deviation (short for “std”) are 0.014, 0.010, and 0.018 m, respectively. The std of velocities and accelerations derived by the position and velocity differentiation are 10, 7, 13 mm/s, 7, 5, 9 mm/s², respectively. This method for getting velocities and accelerations requires higher accurate position coordinates. But the position accuracy has frequently been degraded in this case when the car drove under the trees or other similar kinematical environments. That caused the larger velocity and acceleration errors. While the results from the carrier-phase method are std of the velocities = 2.1 mm/s, 1.3 mm/s, 3.7 mm/s in north, east, down, and std of the accelerations = 1.5 mm/s², 0.9 mm/s², 2.3 mm/s² for the static test period; as compared with KINPOS software results, std of the velocity difference between the carrier-phase method and the DGPS method = 7 mm/s, 6.9 mm/s, 9.7 mm/s in north, east, down direction, and std of acceleration difference = 5.0 mm/s², 4.5 mm/s², 7.5 mm/s² in north, east, down direction for the kinematical test period. Obviously, errors come from both the carrier-phase method and DGPS velocity and acceleration results derived directly by the position differentiation. In addition, better accuracy of positions than that before KF has been got by means of velocities and accelerations derived by the carrier-phase method after KF.     

A review of 9-year performance and operation of the MOPITT instrument

The MOPITT (Measurements of Pollution in the Troposphere) instrument has provided more than nine years of global carbon monoxide (CO) measurements on a continuous basis since its launch aboard the Terra Spacecraft on December 18th, 1999. This paper gives an overview of the core sub-system performance and major issues of the in-flight instrument over the mission period. Some of the instrument anomalies are also discussed. The major successes are: (1) the concept of using a combination of correlation systems such as Length Modulated Cells (LMCs) and Pressure Modulated Cells (PMCs) to retrieve CO profiles in the troposphere; (2) the redundant design in the instrumentation which was crucial for coping with unexpected in-flight anomalies and for continuing the mission in the case of component failure; (3) the thermal environment on orbit that is so stable that some calibration procedures are not necessary; and (4) the recent production of CO total column retrieved from the MOPITT 2.3 μm channel.     

基于H∞理论的二级倒立摆控制研究

二级倒立摆是一种典型的非线性不稳定系统，被广泛用于研究和验证各种控制方法。基于H∞理论控制方法的特点是鲁棒性很强，以尝试采用基于H∞理论控制方法对二级倒立摆进行运动控制，经过仿真实验证明，该控制方法可行并且有效。     

飞机输流管道振动的最优控制

研究了飞机输流管道振动的最优控制问题。对于具有弹性支承和非线性运动约束的悬臂输流管道 ,使用压电片作为控制执行元件 ,推导了受控输流管的运动方程 ,设计了振动的最优控制器 ,并对输流管运动响应进行了数值仿真     

直升机旋翼桨毂轴颈疲劳裂纹探讨

本文就国内外铰接式金属旋翼桨(?)轴颈因疲劳裂纹、断裂导致的严重飞行事故,操讨轴颈疲劳裂纹的成因及扩展速率,应采取的相应对策。对于新机的研制和生产有借鉴意义,对于直升机的使用、维护,保证飞行安全,有重要的现实意义和长远的军事意义。     

某航空活塞发动机机械增压器旁通阀门开启特性分析

机械增压器现已在汽车发动机上得到了广泛应用,但其在航空活塞发动机上的应用和研究较少.分析机械增压器的工作过程,在簧片阀模型的基础上,考虑旁通阀门启闭压力与涡轮增压器压比之间的线性关系并对其建模;搭建某型航空活塞发动机GT-POWER数值仿真模型并进行实验验证,在整机模型的基础上,研究不同转速下通过旁通阀门的质量流率以及不同高度下旁通阀门的通流面积.结果表明:巡航工况下,海拔2680 m时阀门关闭;起飞工况下,海拔3000 m阀门关闭,该结果可为发动机实际高空飞行提供理论支持.     

复合材料层板一维穿透脱层的能量释放率

建立了含穿透脱层的正交各向异性层合板在承受面内轴向压缩载荷作用时的一维分析模型。在一阶剪切层板理论的基础上,利用一维可动边界变分问题,结合断裂力学知识导出了脱层扩展的能量释放率G及其分量G_Ⅰ、G_Ⅱ的表达式,且验证了该方法的正确性。通过计算,讨论了外载和脱层长度对能量释放率的影响。     

飞机的伺服-气动弹性稳定性

现代飞机的自动控制系统都具有控制与增稳两种功能,它通过伺服系统与控制面相连。这种系统与控制对象——飞机之间形成一个闭合回路,如图1所示。考虑到控制系统与飞机两者间动力学特性的相互作用,构成一系列性质各异的回路问题。根据他们不同的外部条件和涉及面的特性差异,形成了多种现象,其中一个引人注目的问题就是闭合回路的稳定性问题。通常在把控制系统或结构作为单独分支而设计时是稳定的,而把它们串联起来成为一个整体时,系统的稳定性就发生了变化。