Upregulation of erythropoietin receptor in UT-7/EPO cells inhibits simulated microgravity-induced cell apoptosis

Hematopoietic progenitor cell proliferation can be altered in either spaceflight or under simulated microgravity experiments on the ground, however, the underlying mechanism remains unknown. Our previous study showed that exposure of the human erythropoietin (EPO)-dependent leukemia cell line UT-7/EPO to conditions of simulated microgravity significantly inhibited the cellular proliferation rate and induced cell apoptosis. We postulated that the downregulation of the erythropoietin receptor (EPOR) expression in UT-7/EPO cells under simulated microgravity may be a possible reason for microgravity triggered apoptosis. In this paper, a human EPOR gene was transferred into UT-7/EPO cells and the resulting expression of EPOR on the surface of UT-7/EPO cells increased approximately 61% (p < 0.05) as selected by the antibiotic G418. It was also shown through cytometry assays and morphological observations that microgravity-induced apoptosis markedly decreased in these UT-7/EPO–EPOR cells. Thus, we concluded that upregulation of EPOR in UT-7/EPO cells could inhibit the simulated microgravity-induced cell apoptosis in this EPO dependent cell line.     

基于B/S架构的设备全寿命周期管理系统技术研究

研究了基于B/S架构(Browser/Server结构)的设备全寿命周期管理系统相关技术,论述了构成设备全寿命周期管理系统的架构设计与模块划分。将网络、多媒体、数据库等技术通过计算机软件系统开发的理论、技术和方法建立起的B/S架构应用于航空聚合物基复合材料厂的设备管理。该系统可使相关基础管理工作以信息化手段简化、固化与落实。     

Kalman filtering for GPS/magnetometer integrated navigation system

This paper investigated the data processing method for a GPS/IMU/magnetometer integrated system with Kalman filtering (KF). As a result of GPS/IMU/magnetometer land vehicle system, dead-reckoning of magnetometer and accelerometer integrated subsystem bridged very well the GPS signal outage due to the trees on the two sides of the road. Both differential GPS data processing method and the carrier-phase method with magnetometers’ outputs for predicting the car position, velocity, and acceleration (PVA) are presented. The results from DGPS with Kinematical Positioning (KINPOS) software shown that the averages of the north, east, and down direction standard deviation (short for “std”) are 0.014, 0.010, and 0.018 m, respectively. The std of velocities and accelerations derived by the position and velocity differentiation are 10, 7, 13 mm/s, 7, 5, 9 mm/s², respectively. This method for getting velocities and accelerations requires higher accurate position coordinates. But the position accuracy has frequently been degraded in this case when the car drove under the trees or other similar kinematical environments. That caused the larger velocity and acceleration errors. While the results from the carrier-phase method are std of the velocities = 2.1 mm/s, 1.3 mm/s, 3.7 mm/s in north, east, down, and std of the accelerations = 1.5 mm/s², 0.9 mm/s², 2.3 mm/s² for the static test period; as compared with KINPOS software results, std of the velocity difference between the carrier-phase method and the DGPS method = 7 mm/s, 6.9 mm/s, 9.7 mm/s in north, east, down direction, and std of acceleration difference = 5.0 mm/s², 4.5 mm/s², 7.5 mm/s² in north, east, down direction for the kinematical test period. Obviously, errors come from both the carrier-phase method and DGPS velocity and acceleration results derived directly by the position differentiation. In addition, better accuracy of positions than that before KF has been got by means of velocities and accelerations derived by the carrier-phase method after KF.     

A review of 9-year performance and operation of the MOPITT instrument

The MOPITT (Measurements of Pollution in the Troposphere) instrument has provided more than nine years of global carbon monoxide (CO) measurements on a continuous basis since its launch aboard the Terra Spacecraft on December 18th, 1999. This paper gives an overview of the core sub-system performance and major issues of the in-flight instrument over the mission period. Some of the instrument anomalies are also discussed. The major successes are: (1) the concept of using a combination of correlation systems such as Length Modulated Cells (LMCs) and Pressure Modulated Cells (PMCs) to retrieve CO profiles in the troposphere; (2) the redundant design in the instrumentation which was crucial for coping with unexpected in-flight anomalies and for continuing the mission in the case of component failure; (3) the thermal environment on orbit that is so stable that some calibration procedures are not necessary; and (4) the recent production of CO total column retrieved from the MOPITT 2.3 μm channel.     

优秀人才是飞机结构设计创新的源动力

根据未来先进战斗机发展的需要和飞机设计队伍的现状，指出了培养优秀飞机人才的紧迫性。论述了优秀飞机结构设计师应具备的基本素质、知识结构和专业技能。提高了改革人才培养机制，激励人才成长的建议。     

基于H∞理论的二级倒立摆控制研究

二级倒立摆是一种典型的非线性不稳定系统，被广泛用于研究和验证各种控制方法。基于H∞理论控制方法的特点是鲁棒性很强，以尝试采用基于H∞理论控制方法对二级倒立摆进行运动控制，经过仿真实验证明，该控制方法可行并且有效。     

飞机输流管道振动的最优控制

研究了飞机输流管道振动的最优控制问题。对于具有弹性支承和非线性运动约束的悬臂输流管道 ,使用压电片作为控制执行元件 ,推导了受控输流管的运动方程 ,设计了振动的最优控制器 ,并对输流管运动响应进行了数值仿真     

直升机旋翼桨毂轴颈疲劳裂纹探讨

本文就国内外铰接式金属旋翼桨(?)轴颈因疲劳裂纹、断裂导致的严重飞行事故,操讨轴颈疲劳裂纹的成因及扩展速率,应采取的相应对策。对于新机的研制和生产有借鉴意义,对于直升机的使用、维护,保证飞行安全,有重要的现实意义和长远的军事意义。     

基于多代理的车间调度系统结构和调度流程的研究

提出了基于多代理机制的车间调度系统的体系结构,为车间调度系统引入管理Agent、任务Agent和资源Agent,并给出了不同Agent的职能;根据合同网协议的招投标过程提出基于多代理机制的调度流程,通过任务Agent和资源Agent的交互协调来完成任务与资源的分配关系。     

基于改进的动态故障树的惯导系统安全性分析

惯导系统的安全性是影响整个飞行器安全的重要因素.在利用动态故障树对惯导系统进行安全性分析时,针对马尔科夫链的组合爆炸和无法分析事件服从非指数分布系统的问题,引入了Monte - Carlo方法.提出了一种基于改进的最小割集的动态故障树分析方法,该方法通过改进最小割集的生成方法,确定相应的分析流程,综合了二元决策图、马尔...