Changes in organ perfusion and weight ratios in post-simulated microgravity recovery

Head-down tilt models have been used as ground-based simulations of microgravity. Our previous animal research has demonstrated that there are significant changes in fluid distribution within 2 h after placement in a 45 degrees head-down tilt (45HDT) position and these changes in fluid distribution were still present after 14 days of 45HDT. Consequently, we investigated changes in fluid distribution during recovery from 16 days of 45HDT. Changes in radioactive tracer distribution and organ/body weight ratio were examined in rats randomly assigned to a 45HDT or prone control group. The 45HDT rats were suspended for 16 days and then allowed to recover at the prone position 0, 77, 101, or 125 h post-suspension. Animals were injected with technetium-labeled diethylenetriamine pentaacetate (99mTcDTPA, MW=492 amu, physical half-life of 6.02 h) and then killed 30 min post-injection. Lungs, heart, liver, spleen, kidneys, and brain were harvested, weighed, and measured for radioactive counts. Statistical analyses included two-way analysis of variance (ANOVA) that compared 45HDT versus controls at the four experimental time points. The organ weight divided by the body weight ratio for the brain, heart, kidneys and liver in the 45HDT rats was significantly different than the control rats, regardless of time (treatment). There was no difference between the different time points (time). The average 99mTcDTPA count divided by the organ weight ratio values for the heart, liver, and spleen were significantly higher in the 45HDT group than the control group. The average counts for the heart and spleen were significantly higher at 77, 101, and 125 h than at time zero. We conclude that the major organs have different recovery patterns after 45HDT for 16 days in the rat.     

Choroidal responses in microgravity. (SLS-1, SLS-2 and hindlimb-suspension experiments)

Fluid and electrolyte shifts occuring during human spaceflight have been reported and investigated at the level of blood, cardio-vascular and renal responses. Very few data were available concerning the cerebral fluid and electrolyte adaptation to microgravity, even in animal models. It is the reason why we developed several studies focused on the effects of spaceflight (SLS-1 and SLS-2 programs, carried on NASA STS 40 and 56 missions, which were 9- and 14-day flights, respectively), on structural and functional features of choroid plexuses, organs which secrete 70–90 % of cerebrospinal fluid (CSF) and which are involved in brain homeostasis. Rats flown aboard space shuttles were sacrificed either in space (SLS-2 experiment, on flight day 13) or 4–8 hours after landing (SLS-1 and SLS-2 experiments). Quantitative autoradiography performed by microdensitometry and image analysis, showed that lateral and third ventricle choroid plexuses from rats flown for SLS-1 experiment demonstrated an increased number (about x 2) of binding sites to natriuretic peptides (which are known to be involved in mechanisms regulating CSF production). Using electron microscopy and immunocytochemistry, we studied the cellular response of choroid plexuses, which produce cerebrospinal fluid (CSF) in brain lateral, third and fourth ventricles. We demonstrated that spaceflight (SLS-2 experiment, inflight samples) induces changes in the choroidal cell structure (apical microvilli, kinocilia organization, vesicle accumulation) and protein distribution or expression (carbonic anhydrase II, water channels,…). These observations suggested a loss of choroidal cell polarity and a decrease in CSF secretion. Hindlimb-suspended rats displayed similar choroidal changes. All together, these results support the hypothesis of a modified CSF production in rats during long-term (9, 13 or 14 days) adaptations to microgravity.     

基于粒子滤波的被动多基站跟踪算法

针对被动多基站跟踪的实际应用，提出了基于粒子滤波的被动多基站跟踪方法。该方法首先利用两个基站的观测数据融合目标位置，并用第三个基站的观测数据对目标位置进行检验，消除了错误融合位置；然后，推导了被动多基站粒子滤波模型，并根据被动多基站跟踪的特点，提出了顺序重抽样方法，有效地解决了被动多基站跟踪中的高度非线性、非高斯的影响；最后，给出了算法的性能仿真比较。仿真结果表明提出的方法性能明显优于其他跟踪方法（如PMHT、IMM-PDA）。     

基于改进蚁群算法的巡航导弹航迹规划

研究了一种基于改进蚁群算法的巡航导弹航迹规划方法，以规划出生存概率更大、飞行距离更短的攻击轨迹，有效提高巡航导弹的作战效能。提出了坐标变换的思想，通过坐标变换将蚁群算法中信息素局部更新策略和全局更新策略协同作用的机制合理地应用到了航迹规划中，通过将信息素全局更新规则中的信息素常量和挥发率进行自适应变化来对算法进行了改进，最后对算法进行了计算机编程仿真实现。仿真结果验证了改进算法能有效避免算法过早陷入局部最优，加快算法的收敛速度，能取得目标函数更优的航迹规划路径。     

具有容错性的自重构机器人变形原理

自重构机器人通过自主变形来适应环境和任务的需要，它具有低成本、多样性、自修理和容错性等特点。本文针对系统的容错性目标，深入研究了具有容错性的自重构机器人的自组织变形方法。首先建立能够表达失效模块信息的系统结构描述模型；然后建立自重构机器人的模块运动规则；提出可以实现容错性的自组织变形算法。在系统出现失效模块的情况下，机器人依然能够有效完成指定的任务。本文以平面正方形晶格机器人翻越障碍物为例对变形原理和算法进行了验证和仿真。     

小波变换在遥测信号检测中的应用

为了更好地分析和处理弹载固态记录仪所记载的助推火箭在发射时对弹体的冲击和振动信号，本文利用小波变换所具有的空间局部化性质，在对原始采样数据的奇异性及奇异性位置和奇异度的大小的分析中，以及在导弹型号试射实验的后视数据分析中，取得出了良好的分析效果。     

基于FPGA高效实现FIR滤波器的研究

文章对FPGA中FIR滤波器的高效实现进行了研究。介绍了流水线技术的原理和应用,比较了整数的CSD表示和根据FPGA结构加以改进的最优表示,提出了FIR滤波器高效实现的措施。最后以具体实例说明了这些措施的可行性和有效性。     

惯性平台框架类结构件的试验模态分析

为了更好的设计和改善结构的动态特性，从而提高产品及工程的质量，应用结构动态分析和计算方法，针对某型号惯性平台框架类结构件进行了模态试验分析，得出了各结构件在0～2000Hz内的各阶固有频率和振型，并通过将试验模态分析的结果和有限元分析结果进行对比，对有限元建模和分析结果的正确性给予了验证。最后，文中提出了各框架结构件设计中存在的薄弱点和相应的优化措施，为今后结构的设计改进和动力学分析奠定了基础。     

The effect of small vibrations on Marangoni convection and the free surface of a liquid bridge

The effects of small vibrations on Marangoni convection were investigated experimentally using a liquid bridge of 5 cSt silicone oil with a disk diameter of 7.0 mm, and an aspect ratio close to 0.5. Experiments were performed to determine the critical temperature difference data for no vibration case and with small vibrations applied. The experimental results have shown that the effect of small vibrations on the onset of oscillatory flow is small since the critical temperature difference data for different aspect ratios were not affected by the vibrations. To clarify the surface oscillation phenomena induced by external vibrations, a 3-D numerical simulation model was also developed using a level set algorithm to predict the surface oscillations of isothermal silicone oil bridges. By subjecting the liquid bridge to small vibrations, the surface oscillation characteristics were predicted numerically, and the numerical results compared well with the predictions of an analytical model proposed previously. Furthermore, the effect of small vibrations on the surface vibration amplitude of the liquid bridge is also discussed.