Occurrence of brain tumors in rhesus monkeys exposed to 55-MeV protons.

Twenty-year observation of monkeys exposed to single doses of high energy protons simulating solar particles revealed that the most prevalent fatal cancers were brain tumors in the group of animals exposed to 55-MeV protons. Of 72 animals (50 males and 22 females) receiving 0.25 to 8.0 Gy total body surface dose, nine developed fatal tumors classified as grade IV astrocytoma or glioblastoma multiforme. The latent period for tumor development ranged from 14 months to 20 years, with a median of 5 years. Doses associated with the tumors were 4.0 to 8.0 Gy. Eight males and one female were affected. Depth-dose determinations suggest that the high incidence of cerebral neoplasia is associated with the Bragg Peak energy distribution of the 55-MeV protons. Comparison of the tumor incidence with that in humans with brain exposures incidental to radiotherapy indicates a high biological effectiveness compared with gamma radiation. Studies are in progress to attempt to replicate the results in rodents and establish a dose-response curve for proton-induced brain tumors.     

非齐次Poisson过程的若干新性质

本文在一些文献的基础上,进一步讨论非齐次Poisson过程的某些性质,给出了若干新性质。 设{N(t),t≥0}是累积强度为的非齐次Poisson过程。迄今的文献(如[1][2]等)指出,(?)n≥1,前n个到达时刻τ_1,τ_2,…,τ_n的联合概率密度为 本文定理1指出,上式不仅是必要的,而且是充分的,并给出了充分性的证明。从而,得到了描写过程统计规律的一个刻画。然后,在N(t_i)=n_i(i=1,…,k,0相似文献   

Chronic hyperhydration and hematological changes in trained subjects during prolonged restriction of motor activity

The objective of this investigation was to evaluate the effect of a daily intake of fluid and salt supplementation (FSS) on the hemoglobin content of endurance trained athletes during hypokinesia (decreased number of steps from 10,000 to 3000 steps per day). The studies were performed on 30 long-distance runners who had a VO2max average of 66 ml kg-1 min-1 and were in the age range of 19-24 years. Prior to their exposure to hypokinesia (HK) of 364 days, all volunteers were on an average of 10,000 steps per day. All volunteers were divided into three equal groups: the first group underwent normal ambulatory life (control subjects), the second group was kept under continuous restriction of motor activity (hypokinetic subjects), and the third group was placed under continuous restriction of motor activity and consumed 26 ml water kg-1 body weight daily and 0.1 g sodium chloride kg-1 body weight in the form of supplementation (hyperhydrated subjects). For simulation of the hypokinetic effect, the number of steps taken per day by the second and third groups of volunteers was restricted to an average of 3000. During the hypokinetic period we determined reticulocytes (Rt), hemoglobin (Hb), hematocrit (Hct), plasma volume (PV), red blood cell (RBC) mass and VO2max. In hyperhydrated volunteers the content of Hb and Hct decreased significantly, while PV, RBC mass and Rt count increased significantly. In hypokinetic volunteers Hb and Hct increased, while PV, RBC and Rt decreased significantly. It was concluded that chronic hyperhydration may be used to attentuate an increase in the Hb content of physically conditioned subjects during prolonged restriction of motor activity.     

Latitude and solar-cycle dependence of radial IMF intensity

I describe a simple procedure for extrapolating the observed solar magnetic field into the heliosphere, which averages the asymptotic fields computed using the standard source surface and current sheet models. The resultant field is characterized by strong latitudinal gradients (maintained by volume currents outside the source surface) and by abrupt reversals in direction at the current sheets. The model yields good agreement with the observed long-term variation of the radial IMF component in the ecliptic, and is used to predict the variation of |B _r | along the latitudinal trajectory of Ulysses during 1990–1994. As found in earlier studies, the magnitude ofB _r at any latitude is determined largely by the strength and relative orientation of the Sun's dipole moment.     

液氧/煤油发动机地面试验故障紧急关机系统研制

论述了液氧／煤油发动机研制地面试车中，出现故障时所采用的紧急关机系统的原理和系统结构、设计程序、设计指标、关机判断准则、验证及应用等。     

Study of water-salt metabolism and renal function in cosmonauts

In manned space flights the renal function and water-salt metabolism undergo substantial changes. With the reserve capabilities of kidneys in mind, their function and regulation of the water-salt balance were investigated in cosmonauts postflight and in Earth-bound simulation experiments with the aid of water loading, hormonal injections (pituitrin, engiotensin, DOCA, ACTH); water- and ion-release were also studied during LBNP and physical exercises. The cosmonauts who performed space flights of 2 to 5 days showed water retention and increased urine excretion of salts during the first postflight days in response to a water load. After the 18-day flight water excretion remained unchanged whereas salt excretion increased. The capacity for osmotic concentration and urine dilution did not alter. The study of the hormonal effect in simulation experiments of different duration demonstrated a normal renal response to the hormonal excretion. After the LBNP tests and physical exercises the water- and salt-excretion declined; a correlation between the level of water- and salt-excretion and the level of these loads was established. The data on the blood- and urine-ionic composition, excretion of nitrogen metabolites, and hormones postflight as well as the results of load and functional tests suggest that changes in the renal function of cosmonauts in weightlessness are associated with regulatory effects on the kidney rather than disturbances in the function of nephron cells.     

Pathophysiology of motor functions in prolonged manned space flights.

The influence of weightlessness on different parts of the motor system have been studied in crew members of 140 and 175 days space flights. It has been shown that weightlessness affects all parts of the motor system including (i) the leg and trunk muscles, in which severe atonia, a decrease of strength and an increase of electromyographic cost of contraction have been observed, (ii) the proprioceptive elements and the spinal reflex mechanisms in which decreased thresholds accompanied by decreases of maximal amplitude of reflexes and disturbances in cross reflex mechanisms have been found. and (iii) the central mechanisms that control characteristics of postural and locomotor activities. The intensities and durations of disturbances of different parts of the motor system did not correlate to each other, but did correlate with prophylactic activity during space flight. The data suggest a different nature of disturbances caused by weightlessness in different parts of the motor system.     

Communications transponder performance for Japanese Communications Satellite-2 and prospects for future systems

Communications transponder for the Japanese Communications Satellite-2 (CS-2a and 2b) to be launched into a geostationary orbit by N-II launch vehicle in February and August, 1983, has been developed. The transponder is provided with six-channel K-band ($\text{30}\text{20}\text{GHz}$) transponder including beacon transmitter, which operates in the highest frequency ranges ever utilized on an operational communications satellite, and two-channel C-band ($\text{6}\text{4}\text{GHz}$) transponder. Receiver front end of the K-band transponder consists of a direct mixer followed by a 1.8 GHz IF amplifier and provides 8 dB noise figure. 20 GHz output power is 4 W by final amplification at 5-W TWTA. C-band transponder provides 4 dB noise figure and 4.3-W output power. Key factors for future high capacity transponder are also presented.     

An Adaptive-Control Switching Buck Regulator-Implementation, Analysis, and Design

Describing-function techniques and averaging methods have been employed to characterize a multiloop switching buck regulator by three functionsl blocks: power stage, analog signal processor, and pulse modulator. The model is employed. to explore possible forms of pole-zero cancellation and the adaptive nature of the control to filter parameter changes. Analysis-based design guide lines are provided including a suggested additional RC-compensation loop to optimize regulator performances such as stability, audiosusceptibility, output impedance, and load transient response.     

The VESTA project: Combined studies of Mars and small bodies of the solar system

A mission to Mars and small solar system bodies is presently studied as a possible collaboration between INTERCOSMOS, CNES, ESA and eventually other participants. The VESTA concept, based on the same strategy as the successful VEGA mission, is more ambitious, as two spacecrafts separate soon after launch: a soviet spacecraft, dedicated to the study of Mars, and a spacecraft dedicated to the study of small bodies, under the responsibility of CNES and ESA. This spacecraft would use Mars gravity assists to visit up to 4 small bodies in less than 5 years. The mission is duplicated, which means that up to 8 small bodies could be studied (e.g. 6 main belt asteroids, 1 apollo-amor asteroid and 1 short period comet). Low relative velocities (< 3.5 km/s) should allow to drop a penetrator on two large main belt asteroids, such as 4 Vesta and 1 Ceres (1994 launch).