Helium-ion-induced human cataractogenesis.

Retrospective and ongoing analyses of clinical records from 347 primary intraocular melanoma patients treated with helium ions at LBL will allow examination of the exposure-response data for human cataract; which is a complication of the therapy from incidental exposure of the lens. Direct particle beam traversal of at least a portion of the lens usually is unavoidable in treatment of posterior intraocular tumors. The precise treatment planned for each patient permits quantitative assessment of the lenticular dose and its radiation quality. We are reporting our preliminary results on the development of helium-ion-induced lens opacifications and cataracts in 54 of these patients who had 10% or less of their lens in the treatment field. We believe these studies will be relevant to estimating the human risk for cataract in space flight.     

Numerical investigation on jet interaction with a compression ramp

A numerical investigation on jet interaction in supersonic laminar flow with a compres- sion ramp is performed utilizing the AUSMDV scheme and a parallel solver. Several parameters dominating the interference flowfield are studied after defining the relative increment of normal force and the jet amplification factor as the evaluation criterion of jet control performance. The computational results show that most features of the interaction flowfield between the transverse jet and the ramp are similar to those between a jet and a flat plate, except that the flow structures are more complicated and the low-pressure region behind the jet is less extensive. The relative force increment and the jet amplification factor both increase with the distance between the jet and the ramp shortening till quintuple jet diameters. Inconspicuous difference is observed between the jet-before-ramp and jet-on-ramp cases. The variation of the injection angle changes the extent of the separation region, the plateau pressure, and the peak pressure near the jet. In the present computational conditions, 120 is indicated relatively optimal among all the injection angles studied. For cold gas simulations, although little influence of the jet temperature on the pressure distribution near the jet is observed under the computation model and the flow parameters studied, reducing jet temperature somehow benefits the improvement of the normal force and the jet efficiency. When the pressure ratio of jet to freestream is fixed, the relative force increment varies little when increasing the freestream Mach number, while the jet amplification factor increases.     

Late effects from particulate radiations in primate and rabbit tissues.

Optic tissues in groups of New Zealand white rabbits were irradiated locally at different stages throughout the median life span of the species with a single dose (9 Gy) of 425 MeV/amu Ne ions (LET infinity approximately 30 keV/micrometer) and then inspected routinely for the progression of radiation cataracts. The level of early cataracts was found to be highest in the youngest group of animals irradiated (8 weeks old), but both the onset of late cataracts and loss of vision occurred earlier when animals were irradiated during the second half of the median life span. This age response can have serious implications in terms of space radiation hazards to man. Rhesus monkeys that had been subjected to whole-body skin irradiation (2.8 and 5.6 Gy) by 32 MeV protons (range in tissue approximately 1 cm) some twenty years previously were analysed for radiation damage by the propagation of skin fibroblasts in primary cultures. Such propagation from skin biopsies in MEM-alpha medium (serial cultivation) or in supplemented Ham's F-10 medium (cultivation without dilution) revealed late damage in the stem (precursor) cells of the skins of the animals. The proton fluxes employed in this experiment are representative of those occurring in major solar flares.     

Optimization of the Energy-Storage Inductors for DC-to-DC Converters

Three sets of design graphs and equations are developed to facilitate design of the energy-storage inductors for dc-to-dc converters. Using the design graphs, a quick estimate of the inductor minimum weight, the transistor peak current, and the inductor power loss can be obtained. Tradeoff studies can be conveniently conducted using these graphs. The effects of duty cycle controllers, constant frequency and constant tON, on the optimal selection of the energystorage inductors are assessed.     

Power Converter Design Optimization

Utilizing the demonstrated capability of nonlinear programming algorithms, a practical design optimization approach for power converters is established which allows conception of a design to meet all power-circuit performance requirements and concurrently optimize a defined quantity such as weight or losses. In addition to facilitating a costeffective design, the computer-aided approach provides a means to readily assess 1) the weight-efficiency tradeoff, 2) impacts of converter requirements and component characteristics on a given design, and 3) optimum powersystem configurations.     

The International Space Station human life sciences experiment implementation process.

The selection, definition, and development phases of a Life Sciences flight research experiment has been consistent throughout the past decade. The implementation process, however, has changed significantly within the past two years. This change is driven primarily by the shift from highly integrated, dedicated research missions on platforms with well defined processes to self contained experiments with stand alone operations on platforms which are being concurrently designed. For experiments manifested on the International Space Station (ISS) and/or on short duration missions, the more modular, streamlined, and independent the individual experiment is, the more likely it is to be successfully implemented before the ISS assembly is completed. During the assembly phase of the ISS, science operations are lower in priority than the construction of the station. After the station has been completed, it is expected that more resources will be available to perform research. The complexity of implementing investigations increases with the logistics needed to perform the experiment. Examples of logistics issues include- hardware unique to the experiment; large up and down mass and volume needs; access to crew and hardware during the ascent or descent phases; maintenance of hardware and supplies with a limited shelf life,- baseline data collection schedules with lengthy sessions or sessions close to the launch or landing; onboard stowage availability, particularly cold stowage; and extensive training where highly proficient skills must be maintained. As the ISS processes become better defined, experiment implementation will meet new challenges due to distributed management, on-orbit resource sharing, and adjustments to crew availability pre- and post-increment.     

Parameterization and adaptive control of space robot systems

In space application, robot system are subject to unknown or unmodeled dynamics, for example, in the tasks of transporting an unknown payload or catching an unmodeled moving object. We discuss the parameterization problem in dynamic structure and adaptive control of a space robot system with an attitude-controlled base to which the robot is attached. We first derive the system kinematic and dynamic equations based on Lagrangian dynamics and the linear momentum conservation law. Based on the dynamic model developed, we discuss the problem of linear parameterization in term of dynamic parameters, and find that in joint space, the dynamics can be linearized by a set of combined dynamic parameters; however, in inertial space linear parameterization is impossible in general. Then we propose an adaptive control scheme in joint space, and present a simulation study to demonstrate its effectiveness and computational procedure. Because most takes are specified in inertial space instead of joint space, we discuss the issues associated to adaptive control in inertial space and identify two potential problem: unavailability of joint trajectory because the mapping from inertial space trajectory is dynamic-dependent and subject to uncertainty; and nonlinear parameterization in inertial space. We approach the problem by making use of the proposed joint space adaptive controller and updating the joint trajectory by the estimated dynamic parameters and given trajectory in inertial space     

A passive millimeter wave camera for aircraft landing in lowvisibility conditions

Fog and low visibility conditions have hampered aviation since its inception. Fog-related accidents are numerous, and canceled take-offs and landings due to fog and low visibility conditions (Cat III) have significant economic impact on airlines, parcel carriers and general aviation. Millimeter waves have good propagation properties in weather and give adequate spatial resolution when used to image the forward scene. Passive millimeter wave focal plane array cameras are new sensors which, integrated into future guidance and landing systems, promise to be an effective aid, or alternative, to existing technology for aircraft landings and take-offs under Cat III conditions. They can produce visual-like radiometric images at real time frame rates (up to 30 Hz), and are directly amenable to image fusion with infrared and visible images. TRW has been actively involved in developing and productizing this technology both at the hardware and the system levels     

A Novel Procedure for Assessing the Accuracy of Hyperbolic Multilateration Systems

This paper describes a novel procedure for determing the accuracy of hyperbolic multilateration systems. Basically, the procedure links the conventional accuracy measures (e. g., GDOP) to the moments and products of inertia of a mass configuration that is easily derived from the system geometry. Thus, the problem of determining accuracy measures is reduced to that of calculating simple moments and products of inertia. The insight provided by the procedure makes it possible to derive a variety of useful approximations for GDOP and other accuracy measures.